Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facilityArticle Published on 2022-02-242022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] AstraZeneca Cambridge Charles River Laboratory clinical sample COVID-19 COVID-19 testing diagnostic Direct driving Effectiveness Efficiency generate GlaxoSmithKline heat High-throughput screening Improving Infectious-disease diagnostics lab Laboratory PCR per day Performance metrics protocol required RNA extraction SARS-CoV-2 Testing UK Government university [DOI] 10.1038/s41598-022-06873-6 PMC 바로가기 [Article Type] Article
Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing낮은 위험과 효율적인 고 처리량 QRT-PCR 진단 테스트를 위해 산업 규모로 임상 코비드 -19 샘플의 열 비활성화Article Published on 2022-02-212022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] activity addition biosafety calibrated confirmed cases COVID-19 COVID-19 sample death diagnostic Effect ergonomics greater handling heat heat inactivation Heating High-throughput screening human SARS-CoV-2 IMPROVE inactivation Infectious-disease diagnostics lab Laboratory less level 2 murine neutralisation open operator Patient performed protocol qRT-PCR recorded reduce restrict risk RNA extraction RT-qPCR RT-qPCR test SARS-CoV-2 sensitivity Spread subsequent swab sample tested validation process virus inactivation writing [DOI] 10.1038/s41598-022-06888-z PMC 바로가기 [Article Type] Article
Detecting SARS-CoV-2 lineages and mutational load in municipal wastewater and a use-case in the metropolitan area of Thessaloniki, GreeceArticle Published on 2022-02-172022-10-04 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] Alpha variant approach B.1.1.7 Community Computational biology and bioinformatics correlation COVID-19 pandemic domination evaluated Evolution Github Greece High-throughput screening methodology MONITOR Mutation Next-generation sequencing NGS Patient Prevalence produced Registered SARS-CoV-2 lineage SARS-CoV-2 RNA SARS-CoV-2 variant Sequencing Software Spread Thessaloniki variant virus was tested [DOI] 10.1038/s41598-022-06625-6 PMC 바로가기 [Article Type] Article
Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2Article Published on 2022-02-052023-07-07 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), [키워드] 3CLpro High-throughput screening inhibitor Merbromin protease SARS-CoV-2 [DOI] 10.1016/j.bbrc.2021.12.108 PMC 바로가기
Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discoveryarticle Published on 2022-01-312024-09-01 Journal: International Journal of Epidemiology [Category] 말라리아, [키워드] anti-adhesion compounds cytoadhesion High-throughput screening PfEMP1 proteins Plasmodium falciparum severe malaria [Article Type] article
Automated liquid handling robot for rapid lateral flow assay development신속한 측면 유동 분석 개발을 위한 자동화된 액체 처리 로봇Research Paper Published on 2022-01-292022-10-28 Journal: Analytical and bioanalytical chemistry [Category] COVID-19, MERS, SARS, 말라리아, [키워드] Abstract antibody automated Concentration continuous variable demonstrated diagnostics effort experiment handling High-throughput screening Infectious disease Intensive lateral flow lateral flow assay malaria Mycobacterium tuberculosis optimization platform point-of-care Pregnancy reduce reproducibility required resource SARS-CoV-2 supplementary material toxin Validity while [DOI] 10.1007/s00216-022-03897-9 PMC 바로가기 [Article Type] Research Paper
Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitorsMethodology Published on 2021-12-052022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] 3CL protease inhibitor acute respiratory syndrome Analysis antiviral agent approved BAS catalytic site caused Chinese traditional medicine conserved coronavirus coronavirus disease COVID-19 COVID-19 patients develop development Dieckol docking Ecklonia cava enzyme evaluated exhibited Fluorescence polarization genomic RNA high affinity High-throughput screening highest identify in viral in vitro inhibitor Interaction Main protease inhibitor MPro pandemic polyprotein predicted protease Proteases Replication Result SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro selective SPR Spread therapeutic agent therapeutic target Treatment [DOI] 10.1186/s13578-021-00720-3 PMC 바로가기 [Article Type] Methodology
A high-throughput pipeline for scalable kit-free RNA extraction확장 가능한 키트가없는 RNA 추출을위한 고 처리량 파이프 라인Article Published on 2021-12-012022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] Accuracy acquisition added approach Assay systems Automation clinical diagnose clinical diagnoses diagnose diagnostic diagnostic sensitivity downstream High-throughput screening Infectious disease Infectious-disease diagnostics Interference Laboratory techniques and procedures miniaturization molecular offer protocol RNA RNA extraction robust RT-qPCR SARS-CoV-2 detection sensitivity Supply chain Volume volume acquisition [DOI] 10.1038/s41598-021-02742-w PMC 바로가기 [Article Type] Article
Dried blood sample analysis by antibody array across the total testing processArticle Published on 2021-10-152022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] Analysis analyzed antibody approach Assay systems Blood blood sample Cytokines database heterogeneity High-throughput screening overcome Protein proteomic Proteomic analysis proteomics provided quantitation Quantitative serum utility Volume volumetric widespread [DOI] 10.1038/s41598-021-99911-8 PMC 바로가기 [Article Type] Article
Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections디페닐부틸피페리딘 계열 항정신병 약물을 결핵균 및 살모넬라 감염의 숙주 지향 치료로 재목적화하기Article Published on 2021-10-042024-07-29 Journal: Burma Med J [Category] 살모넬라증, [키워드] Antimicrobial responses High-throughput screening Immunotherapy Infectious diseases Innate immune cells Tuberculosis [DOI] 10.1038/s41598-021-98980-z PMC 바로가기 [Article Type] Article