Histopathological assessments reveal retinal vascular changes, inflammation, and gliosis in patients with lethal COVID-19조직병리학적 평가는 치명적인 COVID-19 환자의 망막 혈관 변화, 염증 및 신경교증을 나타냅니다Inflammatory Disorders Published on 2021-10-292022-09-11 Journal: Graefe's Archive for Clinical and Experimental Oph [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] abnormality age-matched control Analysis assessment caused change changes changes in choroid controls COVID-19 COVID-19 infection COVID-19 infections COVID-19 samples density determine Donor donors Effect evaluated Ex vivo eye eyes Fundus gliosis hemorrhage hemorrhages Hemorrhagic histology histopathological Histopathology immunocytochemistry indicated Infection Inflammation macroscopic Macula marker negative test ocular Patient processed provide rationale Region Result Retina SARS-CoV-2 SARS-COV-2 infection Seven statistically significant supplementary material the SARS-CoV-2 tissue Vascular vasculature virus vitreous were assessed whole mount [DOI] 10.1007/s00417-021-05460-1 PMC 바로가기 [Article Type] Inflammatory Disorders
Prospective, multicentre, randomised controlled trial comparing the seroclearance of HBsAg between combination therapy of peg-interferon alpha and tenofovir with tenofovir monotherapy in nucleos(t)ide analogue-experienced patients with HBV-related liver fibrosis: a study protocolArticle Published on 2021-10-252023-06-13 Journal: BMJ Open [Category] B형 간염, [키워드] clinical trials hepatobiliary disease hepatology histology [DOI] 10.1136/bmjopen-2021-049104 PMC 바로가기
Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 InfectionOriginal Article Published on 2021-10-252022-10-30 Journal: Inflammation [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 age analysed characterisation Colon colonic contribute controls coronavirus SARS-CoV-2 COVID-19 COVID-19 cohort Crohn’s disease Crohn’s disease cytoplasmic dataset enterocytes Evidence expressed expression fatal COVID-19 Frequency Gut gut biology histologic histology IBD ileal Immune cell immune response Inflammation Inflammatory bowel disease intestinal lamina propria Lungs membrane molecule morbidity and mortality mucosa Multiple myeloma no difference Patient Plasma cell Plasma cells Protein provide recent Regulatory SARS-CoV-2 SARS-COV-2 infection shown significantly higher staining staining intensity supplementary material tissue expression TMPRSS2 TMPRSS2 expression UC ulcerative colitis viral tropism widespread [DOI] 10.1007/s10753-021-01567-z PMC 바로가기 [Article Type] Original Article
COVID-19 Lung Pathogenesis in SARS-CoV-2 Autopsy CasesImmunology Published on 2021-10-042022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome alveolar Analysis analyzed B cell cellular response characterized Combination Consequences coronavirus COVID-19 Cytokine storm demise described disease fibroblast fibrosis hemorrhage hemorrhagic events heterogeneous histology Host immune immune activation Immune cell infiltration immune infiltration immune response lung lung damage Lung pathology lung tissue marker Microscopy patients phenotype Phenotypes post-mortem lung proliferation public health SARS – CoV – 2 SARS-CoV-2 second staining strong immune response T cell tissue tissue damage uninfected virus with COVID-19 [DOI] 10.3389/fimmu.2021.735922 PMC 바로가기 [Article Type] Immunology
Proven COVID-19-associated pulmonary aspergillosis in patients with severe respiratory failure중증 호흡부전 환자에서 입증된 COVID-19 관련 폐 아스페르길루스증Article Published on 2021-10-012022-09-11 Journal: Mycoses [Category] MERS, SARS, 진단, 치료기술, [키워드] Aspergillus Autopsies CAPA clinical Clinical data collected Comorbidities Consensus COVID-19 described diagnosed diagnoses diagnostic epidemiological data Epidemiology females First wave Frequency histology incidence intensive care intensive care unit International laboratory data laboratory-confirmed Lung disease Lung diseases male median age medical mycology Mortality pandemic Patient performed pulmonary aspergillosis radiological feature radiological features reported SARS-CoV-2 second wave Seven severe COVID-19 severe respiratory failure supported to define university Validity [DOI] 10.1111/myc.13342 PMC 바로가기 [Article Type] Article
Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virusArticle Published on 2021-09-302022-10-04 Journal: Scientific Reports [Category] 비임상, [키워드] benefit Biomarker blinded early infection Ebola virus Ebola virus disease Ebola virus infection histology improvement Infection Infectious diseases initiated lung lymphoid tissues Microbiology mucosal exposure observation outcome pathology performed Randomized reduction in Remdesivir resulting Rhesus monkey serum survival Treatment viral titer Virology [DOI] 10.1038/s41598-021-98971-0 PMC 바로가기 [Article Type] Article
Emerging and Established Histological Techniques for the Analysis of Thrombosis in COVID-19 LungsCardiovascular Medicine Published on 2021-09-212022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute respiratory syndrome caused coronavirus Coronavirus disease 2019 COVID - 19 COVID-19 COVID-19 treatments described dimensions gold standard histological histology increased risk lethal disease lung MINI Pathogenesis progression pulmonary review SARS-CoV-2 severe COVID-19 technique thrombosis with COVID-19 [DOI] 10.3389/fcvm.2021.745906 PMC 바로가기 [Article Type] Cardiovascular Medicine
Fatal pulmonary thromboembolism in asymptomatic COVID-19Original Article Published on 2021-09-052022-10-30 Journal: Irish Journal of Medical Science [Category] COVID-19, SARS, [키워드] Asymptomatic Asymptomatic COVID-19 Autopsy cardiac disease Cardiomyopathy caused claimed conducted Coronary artery disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis death deaths described died Endothelium fibrosis heart failure histology hypertensive identify incidence Infection literature review massive Non-COVID-19 Pathogenesis pathological finding Post-mortem Pulmonary thromboembolism Result SARS-CoV-2 SARS-COV-2 infection Thromboembolism thrombosis ventricular [DOI] 10.1007/s11845-021-02735-8 PMC 바로가기 [Article Type] Original Article
Positive Retrospective SARS-CoV-2 Testing in a Case of Acute Respiratory Distress Syndrome of Unknown Etiology.Case Report Published on 2021-08-282022-10-31 Journal: Case Reports in Pulmonology [Category] COVID-19, [키워드] acute respiratory distress Autopsy death diagnosed Diffuse alveolar damage etiology Evidence histology identify immunofluorescence In situ hybridization molecular Multiorgan Patient Protein reported respiratory respiratory virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA state syndrome Testing Unknown were used widespread [DOI] 10.1155/2021/5484239 PMC 바로가기 [Article Type] Case Report
SARS‐CoV‐2 and the brain: A review of the current knowledge on neuropathology in COVID‐19Review Published on 2021-08-132023-06-16 Journal: Brain pathology (Zurich, Switzerland) [Category] MERS, SARS, [키워드] Autopsy Central nervous system COVID‐19 histology neurological manifestation Neuropathology [DOI] 10.1111/bpa.13013 PMC 바로가기 [Article Type] Review