SARS-CoV-2 Outbreak on a Spanish Mink Farm: Epidemiological, Molecular, and Pathological StudiesVeterinary Science Published on 2022-01-212022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] acute respiratory syndrome Analysis antibodies Brain Clinical sign collected contributing to coronavirus COVID-19 epidemic Genetic variant histopathological humans Infection mink molecular nasal nucleocapsid occurred outbreak pathological Pneumonia polymerase chain reaction positive prevalent reported risk RT-qPCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence sequence seroconverted serological seropositive Spain Spanish Spread Surveillance susceptible tissue virus virus spread [DOI] 10.3389/fvets.2021.805004 PMC 바로가기 [Article Type] Veterinary Science
Placental deficiency during maternal SARS-CoV-2 infection산모의 SARS-CoV-2 감염 중 태반 결핍Multicenter Study Published on 2022-01-012022-09-12 Journal: Placenta [Category] MERS, SARS, 진단, [키워드] abnormality age anti-SARS-CoV-2 anti-SARS-CoV-2 IgM antibody change Clinical severity collected Concentration correlated COVID-19 cross deficiency disease evaluate feature fetal Gross histopathological indicated Infection Maternal moderate mother Nasopharyngeal swab Neonatal Neonate Neonates outcome outcomes pathology Placenta placental Placental infection Placental pathological findings positive Pregnancy pregnant women prospective cohort study Prospective Study Protein reported risk SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection sera severe disease severity spike staining structures Swab the disease transmission of SARS-CoV-2 umbilical [DOI] 10.1016/j.placenta.2021.10.012 PMC 바로가기 [Article Type] Multicenter Study
Postmortem Biopsies of the Lung, Heart, Liver, and Spleen of COVID-19 PatientsRadiology Published on 2021-12-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acquisition alteration autopsy studies biopsies biopsy Case series Characteristics Chest computed tomography collected Complete coronavirus disease correlated COVID-19 died Diffuse alveolar damage evaluate examined feasible FIVE Ground-glass opacities heart heart tissue histopathologic histopathological infiltration liver lung lung biopsy Lungs material Microscope mononuclear cell Necrosis neutrophil infiltration nonspecific objective Patient patients performed Postmortem Result SARS-CoV-2 specimens spleen spleen tissue Splenic steatosis the patient tissue Treatment underlying disease were stained [DOI] 10.7759/cureus.20734 PMC 바로가기 [Article Type] Radiology
SARS-CoV-2 Variants of Concern Infect the Respiratory Tract and Induce Inflammatory Response in Wild-Type Laboratory MiceSARS-COV-2 관심의 변이체는 호흡기를 감염시키고 야생형 실험실 마우스에서 염증 반응을 유도합니다.Brief Report Published on 2021-12-242022-09-10 Journal: Viruses [Category] SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation addition analyzed B.1 B.1 lineage B.1.1.7 B.1.351 C57BL/6 C57BL/6 mice CCL2 change chemokine chemokines Concentration concern Coronavirus-2 COVID-19 cytokine Cytokines evaluated expression greater histopathological Host host-range hosts IL-1β IL-6 Immune escape infecting Infection Inflammation inoculated intranasally lineages lung lung tissue lung tissues Lungs mice mouse mouse-adapted SARS-CoV-2 mRNA level mRNA levels multiple cytokine multiple cytokines Mutation pathogenicity public health replicated respiratory response robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein the spike protein These data TNF-α tract Transmissibility upregulated variant variants of concern Viral Viral load viral nucleocapsid protein virulence virus viruses wild-type [DOI] 10.3390/v14010027 PMC 바로가기 [Article Type] Brief Report
3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomographyResearch Article Published on 2021-12-212022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] alteration Analysis analyzed annotations automated cardiac tissue concerning controls COVID-19 dataset deep learning distribution elevated High-resolution histopathological Histopathology Human Influenza Intussusceptive angiogenesis Laboratory measure Microscopy myocarditis Occurrence pathological pathological change Patient progression quantified Radiation Tensor tissue tomography Variation Vascular vessels virus X-ray X-ray tomography [DOI] 10.7554/eLife.71359 PMC 바로가기 [Article Type] Research Article
COVID-19 and SepsisArticle Published on 2021-12-172022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS, [키워드] acute phase reactant acute respiratory distress addition affecting alterations ARDS assist association Autopsy Bacterial sepsis Blood cause caused Cell changes chemokine Clinical deterioration coagulation tests component consolidation contributing to Course COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient COVID-19 sepsis CRP Cytokine storm D-dimer demonstrated Diffuse alveolar damage direct viral infection dominant dysregulated immune response endothelial injury explained Faeces feature ferritin Gallbladder hematological hemorrhage histopathological HLH hospitalized patient Hyperactivation hypercoagulability hypercoagulable hyperinflammation immune immune response IMPROVE indicated infiltration inflammatory cell intrinsic Laboratory laboratory parameter limit liver liver function tests lung tissue Lungs macrophages manifestation modulate multiorgan failure multiple organ organ systems organs outcome overlapping pandemic Pathogenesis pathogenesis of COVID-19 Pathogens Result SARS-CoV-2 Sepsis serum cytokine Severe case severe COVID-19 severe COVID-19 disease Severe COVID-19 Infection severe COVID-19 patients similarity syndrome systemic inflammation tissue Treatment unique Urine Vascular viral disease viral particle virus while [DOI] 10.3906/sag-2108-239 PMC 바로가기 [Article Type] Article
Promising Antiviral Activity of Agrimonia pilosa Phytochemicals against Severe Acute Respiratory Syndrome Coronavirus 2 Supported with In Vivo Mice StudyArticle Published on 2021-12-162022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] abnormality ABTS activity acute lung injury acute respiratory syndrome addition Adsorption Agrimonia pilosa ALI antioxidant antiviral activity Apoptosis assays caspase-3 caused clinical trials Compound comprehensive analysis conducted coronavirus coronavirus 2 coumarin COVID-19 pandemic disease downregulation DPPH Effect evidenced exhibited expression Gene Expression histopathological IL-18 IL-1β IL-6 immunomodulatory immunomodulatory activity Inflammation investigated LC-ESI-MS/MS lipopolysaccharide LPS lung tissue mechanism of action mice mononuclear cells MPO NF-κB oxidative stress patients with COVID-19 Peripheral blood phytochemical plaque reduction protective effect respiratory SARS-CoV-2 scavenging serum TAC therapeutic compound TLR-4 TNF-α Treatment upregulation virucidal were assessed [DOI] 10.3390/ph14121313 PMC 바로가기 [Article Type] Article
Ultrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020초음파 유도 최소 침습 조직 샘플링: 2020년 브라질의 COVID-19 대유행 중 최소 침습 부검 전략Supplement Articles Published on 2021-12-152022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] Accuracy Analysis Autopsies Autopsy autopsy safety biohazard Brazil case sery CDA Complete conducted contribute coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 pathology diagnostic Diseases histopathological identify include infectious agent invasive kidney liver Lungs Microscopy Minimally Invasive Autopsy minimally invasive tissue sampling molecular analysis organ pandemic pathological finding pathology patients with COVID-19 performed polymerase chain protocol provided ranged reduce Result Safe selected Strategy submitted Swab the disease tissue ultrasound guided biopsy were infected [DOI] 10.1093/cid/ciab885 PMC 바로가기 [Article Type] Supplement Articles
Pathogenicity of the Canadian Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) on Female Reproductive Tract of ChickensArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] age bronchitis cause characteristic chicken circulating consequence cystic oviduct Delmarva (DMV)/1639 strain demonstrated determine distribution experiment false layer syndrome female reproductive tract Genome highly pathogenic histopathological IBV incidence Infection Infectious bronchitis virus (IBV) kidney lesion observation over oviduct Prevalence provide respiratory tract SPF syndrome tissue tonsils tract viral shedding virus were infected white leghorn chicken [DOI] 10.3390/v13122488 PMC 바로가기 [Article Type] Article
Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization불 활성화 된 SARS-COV-2 바이러스 면역 후 감마 및 제타 변이체에 대한 보호 면역Article Published on 2021-12-042022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] addition anti-S antibody antibody production cellular response circulation conducted COVID-19 cross-protection cross-reactive demonstrated evade evaluated follow-up study Gamma Gamma variant histopathological IgG IL-6 IL-6 expression immune response immune system Immunity immunization immunized immunized mice inactivated Inactivated vaccine increase individual induce Infection levels of antibody Lungs mice mice immunization Neutralizing activity outcome pathological outcome pathological outcomes performed produced Production reduced reduced viral loads reducing robust SARS-CoV-2 SARS-CoV-2 vaccine Serum Neutralization significantly TNF vaccinated individuals vaccination variant variants Viral viral infection viral loads viral variant WT SARS-CoV-2 Zeta variant [DOI] 10.3390/v13122440 PMC 바로가기 [Article Type] Article