SARS-CoV-2 Shedding from Asymptomatic Patients: Contribution of Potential Extrapulmonary Tissue ReservoirsPerspective Piece Published on 2020-07-132022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS, [키워드] accessory protein affected Antiviral treatment Asymptomatic individuals benefit caused Central nervous system clinical presentation COVID-19 death disease pathogenesis disseminate Extrapulmonary extrapulmonary organ extrapulmonary tissue eyes Gut host cells host immune responses implication include individual infect Ligand Medical countermeasures pandemic patients Perspective Pneumonia Potential recovered patient representing reservoir respiratory symptom Saliva SARS-CoV-2 SARS-COV-2 infection secretion shedding Significant Stool Viral RNA viral shedding virus [DOI] 10.4269/ajtmh.20-0279 PMC 바로가기 [Article Type] Perspective Piece
Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 특성, 진단 및 치료의 면역학적 측면Review Published on 2020-06-042022-08-13 Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, SARS, [키워드] advancement antibodies Antibody-dependent enhancement approach approaches caused Characteristics component components coronavirus coronavirus disease COVID-19 cytokine Cytokine storm Defense develop Diagnosis Diagnostic method diagnostic methods Diseases evade facilitate Health Organization Host Host immune response host immune responses host immune system immune attack immune response immune responses immune system Immunologic Infection Infectious disease Infectious diseases Inflammatory response Innate immunity knowledge Like Lungs mechanism new strain new strain of coronavirus other infectious diseases pandemic proliferate SARS-CoV SARS-CoV-2 SARS-COV-2 infection Spread susceptible individuals the disease therapeutic agents Therapeutic strategies Treatment vaccination virus viruses World Health Organization [DOI] 10.1186/s12929-020-00663-w PMC 바로가기 [Article Type] Review
Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2Article Published on 2020-05-062022-10-04 Journal: Journal of Human Genetics [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] addition allele frequency B-cell response Bioinformatic calculated CD4 CD8 Coverage COVID-19 pandemic Deleterious develop epitope high affinity High-throughput screening HLA HLA class I HLA molecules homology host immune responses immune immune system Immunogenetics induce information Japanese membrane nonstructural protein Novel coronavirus Nucleocapsid proteins other coronaviruses peptide epitope populations predicted Prevent Region SARS-CoV SARS-CoV-2 sequence significantly T cell epitope T-cell T-cell responses the SARS-CoV-2 Vaccine virus [DOI] 10.1038/s10038-020-0771-5 PMC 바로가기 [Article Type] Article
Significant changes of CD4, FOXP3, CD25, and IL6 expression level in Iranian COVID-19 patientsOriginal Article Published on 2020-01-012022-10-31 Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19, [키워드] Analysis blood sample CD25 CD4 cDNA synthesis change collected correlation COVID-19 COVID-19 patient distribution downregulated eight emerging disease evaluated Evaluating expression level expression profile FOXP3 healthy healthy control healthy controls hospitalized COVID-19 patients host immune responses IL-6 IL6 increase in indicated Inflammatory responses interleukin 6 marker patients Peripheral blood quantitative real-time PCR RNA SARS-CoV-2 severity of COVID-19 Significant significantly T cell the disease Total Treg was performed PMC 바로가기 [Article Type] Original Article
The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion ConformationStructure and Assembly Published on 2019-09-182022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] alphacoronavirus spike antigens betacoronaviruses biological processe cause concerning conformation conformational Cryo-electron microscopy cryo-EM described domain effort epidemic diarrhea facilitate glycoprotein glycosylated heterogeneity high mortality rate High-resolution host cells host immune responses IMPROVE in viral Infection information Like macromolecular membrane fusion molecular mechanism N terminus Neonatal NL63 observation other coronaviruses pathogenic PEDV prefusion conformation Receptor binding receptor engagement Receptor-binding domain reveal S protein S1 subunit S1-CTD spike Spike protein Spike proteins Stage Structure subunit the S1 subunit the spike protein These data triggering trimer trimeric spike Vaccine Vaccines virus [DOI] 10.1128/JVI.00923-19 PMC 바로가기 [Article Type] Structure and Assembly
Sticking for a Cause: The Falciparum Malaria Parasites Cytoadherence Paradigm원인에 대한 고수: 팔시파룸 말라리아 기생충의 세포 부착 패러다임Review Published on 2019-06-272024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] cytoadherence host immune responses malaria Pathogenesis Plasmodium [DOI] 10.3389/fimmu.2019.01444 PMC 바로가기 [Article Type] Review
Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation글루코사민은 Crz1 핵 전위를 촉진하여 Cryptococcus neoformans에서 페로몬 독립적인 이형 전이를 자극합니다Research Article Published on 2017-09-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Antifungal antifungal therapy attenuate calcineurin caused Cell cellular response clinically complex component Cryptococcal cells cryptococcal meningitis cryptococcosis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoplasm demonstrated disease downstream effector effectors elicited fertile fungal Genetic genetic screen glucosamine glycerol Host Host immune response host immune responses hosts identity immune responses immune-stimulatory independent independent of Interaction isolate limitations majority mammalian MAPK Meningitis morphogenesis Morphological morphological change Morphotype nuclear translocation nucleus Pathogenesis pathway pheromone phosphatase promote promoted PROTECT raise recent reference strain responsible serotype shown signaling pathway stimulate stimulated strain Stress stress response subsequent suppressed switching transcription factor translocation Trigger undergo Vaccine Vaccine development virulence virulent yeast [DOI] 10.1371/journal.pgen.1006982 PMC 바로가기 [Article Type] Research Article
Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccinesArticle Published on 2016-11-222022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] determine Du et al effective Efficacy elicit eliminated epitope evaluate host immune responses immune responses immunodominant life-threatening MERS coronavirus MERS-CoV Neutralizing non-neutralizing epitope probe significantly subunit Subunit vaccine the receptor-binding domain the vaccine transgenic mice Vaccine Vaccine design variant viruses [DOI] 10.1038/ncomms13473 PMC 바로가기 [Article Type] Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPlasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다Research Article Published on 2013-02-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing [DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article