Parkinson’s Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus SpreadArticle Published on 2021-03-282022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] aspartate carriers Causative Cell characterized disorder ectopic expression Endosomes etiology expressing facilitate Frequency herpes simplex herpes simplex virus host cell HSV-1 implicated Infection Inhibitory effects investigated less misfolded protein mutant Mutation mutations neurodegenerative Neuroinflammation Neuron ortholog overexpressing Parkinson’s disease Parkinson’s disease Parkinsonism precipitated proliferation Protein reduced significantly Spread substantia surface tetherin vacuolar vesicles virus virus spread Vps35 wildtype [DOI] 10.3390/cells10040746 PMC 바로가기 [Article Type] Article
Prolonged fever and hyperferritinaemia: a puzzling diagnosis of neonatal herpes simplex virus infection during COVID-19 pandemic장기간의 발열 및 고페리틴혈증: COVID-19 전염병 동안 신생아 단순 포진 바이러스 감염의 수수께끼 진단Case Reports Published on 2021-03-102022-09-11 Journal: BMJ case reports [Category] SARS, 치료제, [키워드] absence acyclovir Bacterial carried COVID-19 COVID-19 pandemic Diagnosis elevated febrile ferritin Fever full recovery herpes simplex herpes simplex virus highlight HSV-1 incidence Infection Infectious diseases Inflammatory biomarker inflammatory biomarkers initial Intensive male Neonatal neonatal health neonatal intensive care Neonates Newborn paediatrics PCR persistent fever positive Prolonged fever returned SARS-CoV-2 SARS-COV-2 infection Sepsis serology suspicion therapy virus virus infection [DOI] 10.1136/bcr-2020-241405 PMC 바로가기 [Article Type] Case Reports
Life-long passion for antiviral research and drug development: 80th birthday of Prof. Dr. Erik De ClercqReview article Published on 2021-03-012022-10-05 Journal: Biochemical pharmacology [Category] 치료제, [키워드] addition AIDS patients Antiviral antiviral agent antiviral drugs Antiviral research approved Brivudine canine contributed develop driven by Drug discovery effort Erik FIVE fumarate HBV HCMV HCV Hepatitis B virus hepatitis C virus herpes simplex highlight HIV HIV treatment HSV HSV-1 Human Cytomegalovirus Human immunodeficiency virus include Infectious disease lymphoma Multiple myeloma non-Hodgkin’s lymphoma Research tenofovir Treatment valacyclovir virus [DOI] 10.1016/j.bcp.2021.114485 [Article Type] Review article
Why Cells and Viruses Cannot Survive without an ESCRTReview Published on 2021-02-242023-08-30 Journal: Cells [Category] E형 간염, [키워드] cellular membranes ESCRT Extracellular vesicles HSV-1 viruses [DOI] 10.3390/cells10030483 PMC 바로가기 [Article Type] Review
Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2Article Published on 2021-02-202022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] 222A 222B application Bovine coronavirus coated coronavirus develop emerging respiratory viruses herpes simplex HSV-1 HSV-1-GFP inactivated Infection Intervention investigated less Like log Mask prevented reduce respiratory virus respiratory viruses Rhamnolipid rhamnolipids Safe SARS-CoV2 Spread therapy Transmission Vaccine virus viruses [DOI] 10.3390/v13020322 PMC 바로가기 [Article Type] Article
Exploring novel and potent cell penetrating peptides in the proteome of SARS-COV-2 using bioinformatics approachesResearch Article Published on 2021-02-192022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] addition analyses approach binding bioinformatics calculated Cancer therapy Cell cell membrane cells cellular coronaviruses family CPP Efficiency evaluated Features herpes simplex highest HIV-1 homing Host HSV-1 immunodeficiency in silico Infection investigated main role mammalian cells membrane molecular weight motif NLS nuclear penetrate Penetrating penetration peptide physicochemical property predicted Probability proteome proteome of virus residue SARS-CoV-2 sequence submitted Toxicity Vaccine virus [DOI] 10.1371/journal.pone.0247396 PMC 바로가기 [Article Type] Research Article
In Vitro Analysis of the Antioxidant and Antiviral Activity of Embelin against Herpes Simplex Virus-1Article Published on 2021-02-192024-09-02 Journal: Microorganisms [Category] 대상포진, [키워드] antioxidant Antiviral embelin HSV-1 [DOI] 10.3390/microorganisms9020434 PMC 바로가기 [Article Type] Article
Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infectionsObservational Study Published on 2021-02-182022-10-04 Journal: Nature Communications [Category] MERS, 임상, [키워드] acute respiratory syndrome airway CD123 circulating coronavirus COVID-19 negative COVID-19 patients CXCL12 dendritic cell disease epithelial cells exhibiting Health HSV-1 identify IFNα IFNλ increase independent Infection innate antiviral immunity Interleukin-3 marker mice Mortality outcome Patient pDC pDCs plasma plasmacytoid dendritic cell potential therapeutic target Predictive Prognostic marker Prospective Study pulmonary diseases recruitment reduce reduced Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion severe COVID-19 severity Treatment viral infection viral infections Viral load [DOI] 10.1038/s41467-021-21310-4 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Infection (COVID-19) and Herpes Simplex Virus-1 Conjunctivitis: Concurrent Viral Infections or a Cause-Effect Result?Ophthalmology Published on 2021-01-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Antibiotics Atypical cause Complete concurrent Conjunctival secretion conjunctivitis coronavirus disease Coronavirus-2 COVID-19 Dyspnea Effect Evidence eye pain eyelid facial Herpe herpes simplex hospital HSV-1 hypoxic immune system male modulate ocular organ systems positive raise requiring supplemental oxygen Sample SARS-CoV-2 supportive care tested viral infections virus worsening [DOI] 10.7759/cureus.12592 PMC 바로가기 [Article Type] Ophthalmology
Virus-induced p38 MAPK activation facilitates viral infection바이러스 유도 p38 MAPK 활성화로 바이러스 감염 촉진Research Paper Published on 2020-10-302022-09-10 Journal: Theranostics [Category] MERS, SARS, 치료법, [키워드] activate activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral assays binding Cas9 clinical samples confocal microscopy core protein coronavirus correlation CRISPR cultured cell cultured cells determine expected facilitate facilitated Fever GST HCV hepatitis C hepatitis C virus hepatocyte hepatocytes herpes simplex herpes simplex virus herpes simplex virus type 1 HSV-1 immunohistochemistry in viral Infection inhibited Interaction investigated MAP3K7 MAPK mass spectrometry mechanism mitogen-activated protein kinase MOST N-terminal oligomerization P38 activation pathway Patient PCR peptide pharmacological phosphorylated Phosphorylation plaque plaque assays promoted Protein protein kinase qRT-PCR Quantitative quantitative real time PCR rationale real time real time PCR Replication respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus SFTSV signaling pathway siRNA suppressed syndrome TAB1 TGF-β thrombocytopenia tissue triggering Viral viral infection viral infections viral replication virus were used western blotting [DOI] 10.7150/thno.50992 PMC 바로가기 [Article Type] Research Paper