Evaluating alternative hypotheses to explain the downward trend in the indices of the COVID-19 pandemic death rateEpidemiology Published on 2021-04-202022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] age Case fatality rate case fatality ratio caused CFR Changing contribute COVID-19 COVID-19 pandemic death rate declining domain Efficiency evaluate Evaluating Evolution Evolution of virulence Evolutionary medicine explain fatality hypothese hypotheses Immunity Infection Infection fatality rate limitation pandemic pathogen reduced relative contribution Result robust supported systematic analysis the epidemic time lag Treatment protocol variety virulence virus [DOI] 10.7717/peerj.11150 PMC 바로가기 [Article Type] Epidemiology
Delayed care for patients with newly diagnosed cancer due to COVID-19 and estimated impact on cancer mortality in FranceOriginal Research Published on 2021-04-172022-10-31 Journal: ESMO open [Category] COVID-19, MERS, SARS, [키워드] analyzed Breast cancer calculated Cancer Cancer center cancer patient cancer-related death cancers Care clinical activity compensated coronavirus disease country COVID-19 death decrease Delay Delayed diagnosed Diagnosis France hazard ratio hypotheses magnitude management Metastasis Mortality Patient patients Prostate cancer prostate cancers reached reduction reduction in Region Result resulting risk treat treated Treatment was collected was measured women [DOI] 10.1016/j.esmoop.2021.100134 PMC 바로가기 [Article Type] Original Research
Strategies for Immunomonitoring after Vaccination and during InfectionReview Published on 2021-04-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Adaptive immune response approach approaches Conventional Course COVID-19 COVID-19 pandemic Diseases effector Efficacy example help hypotheses immune immune mechanism immune response immune responses immunomonitoring include Infection knowledge question raise Strategy Systems biology Toxicity vaccination Vaccine viral control [DOI] 10.3390/vaccines9040365 PMC 바로가기 [Article Type] Review
Changes in diet quality and food security among adults during the COVID-19-related early lockdown: results from NutriQuébecObservational Study Published on 2021-04-062022-10-05 Journal: The American journal of clinical nutrition [Category] 임상, [키워드] 24-hour recalls added Analysis baseline beans change changes in Cohort coronavirus disease COVID-19 Deterioration Diet quality dietary habit eating eating habits food insecurity healthy hypotheses improvement increase in increases in index individual lockdown obesity participant populations Prevalence Prospective Study Protein Proteins Quebec, Canada questionnaire recall study outcome sugar suggested was reduced web-based study web-based study. [DOI] 10.1093/ajcn/nqaa363 PMC 바로가기 [Article Type] Observational Study
Secondary analysis of transcriptomes of SARS-CoV-2 infection models to characterize COVID-19Article Published on 2021-04-052022-10-28 Journal: Patterns [Category] COVID-19, [키워드] Abstract Analysis association biological processe build changes Cluster Community Consensus coronavirus COVID-19 Data integration Data mining data-driven disease disease models driving elements feature Features functional Gene Expression gene expression signature gene signature Genome-wide association study heterogeneous host protein hypotheses Identified identify information Interaction interactions joint knowledge Meta-analysis model system module detection molecular molecular mechanism multiple model system network analysis outcome outcomes overcome pathophysiological pathophysiology pathway pattern search phenotype protein-protein interaction Research question SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome secondary Single-cell RNA-sequencing Standard Support transcriptional Transcriptome transcriptomic transcriptomics translational utility viral-host protein [DOI] 10.1016/j.patter.2021.100247 PMC 바로가기 [Article Type] Article
Ethical and psychosocial considerations for hospital personnel in the Covid-19 crisis: Moral injury and resilienceResearch Article Published on 2021-04-022022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] analysed approach basic COVID-19 pandemic distress Effect effective essential element Factor Health care worker healthcare healthcare worker hospital hypotheses Injury Italian mental health professional methodology Moral pandemic Patient Psychosocial Resilience Stress Stressor Support with COVID-19 [DOI] 10.1371/journal.pone.0249609 PMC 바로가기 [Article Type] Research Article
Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunityCOVID-19 및 자가면역에서의 인터페론 및 기타 사이토카인, 유전학 및 그 이상Review Published on 2021-04-012022-09-11 Journal: Cytokine & growth factor reviews [Category] 유전자 메커니즘, [키워드] Alpha antibodies antibody antiviral agent Antiviral agents autoantibodies autoantibody Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity B cell cascade Citrullination complement COVID-19 COVID-19 patient COVID-19: antibody cytokine Cytokines Degradation deletions develop Epitopes Extracellular gene defect Gene segment Genetic genetic defect genetic defects genetics glycosylation growth factor Growth factors hematological homozygous hypotheses immunological Immunological studies in vitro induce Infection innate immune interferon Interferon-beta interferons intracellular content intracellular protein intracellular proteins involved lupus erythematosus mechanism MOST neutralization Neutralizing Neutralizing antibodies neutralizing antibody Occurrence Patient POLE posttranslational modifications protease PROTECT proteolysis question regulated Release Research SARS-CoV-2 Seven severe COVID-19 severe inflammation Signaling systemic lupus erythematosus the SARS-CoV-2 Tolerance type 1 interferons virus virus infection virus replication [DOI] 10.1016/j.cytogfr.2021.01.004 PMC 바로가기 [Article Type] Review
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19입원 시 혈액 신경섬유 광 농도: COVID-19의 잠재적인 예후 마커Original Communication Published on 2021-03-202022-09-10 Journal: Journal of Neurology [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Acidic adjusted analyses Adjusted analysis Admission Analysis analyzed Biomarker Biomarkers Blood blood sample Blood samples clinical outcomes Clinical signs CNS Concentration COVID-19 COVID-19 patient COVID-19 patients detect discharged disease severity Effects GFAp Glial fibrillary acidic protein hypothese hypotheses Increased increased mortality Inflammatory biomarker inflammatory biomarkers Injury Inpatient intensive care intensive care unit light chain Linear model linear models measurement MONITOR Mortality nervous system Neurofilament light non-survivor Non-survivors objective on admission overall mortality Patient Prognostic marker Protein repeated Result risk SARS-CoV-2 serum serum biomarker serum biomarkers serum concentrations significantly higher Simoa subgroups survivor Symptoms the patient [DOI] 10.1007/s00415-021-10517-6 PMC 바로가기 [Article Type] Original Communication
Misinformation on COVID-19 origin and its relationship with perception and knowledge about social distancing: A cross-sectional studyResearch Article Published on 2021-03-092022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] age Analysis analyzed collected collected data conducted COVID-19 COVID-19 infection cross-sectional dependent variable Descriptive statistics Evidence FIVE genomic sequencing hypotheses individual individuals information knowledge measure media misinformation morbidity and mortality Multiple linear regression Perception predicted Purposive sampling questionnaire significantly social distancing social distancing measures social media platforms SPSS statistically statistically significant virus [DOI] 10.1371/journal.pone.0248160 PMC 바로가기 [Article Type] Research Article
Antihypertensive Drugs and COVID-19 Risk: A Cohort Study of 2 Million Hypertensive PatientsObservational Study Published on 2021-03-032022-10-05 Journal: Hypertension (Dallas, Tex. : 1979) [Category] SARS, 임상, [키워드] ACE ACE inhibitor ACE inhibitors angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors antihypertensive ARB ARBs associations blocker calcium channel blockers cardiovascular disease CCB CCBs chronic respiratory disease Cohort coronavirus disease COVID-19 COVID-19 hospitalization database diabetes died drug end point Evidence examined excluded French hazard ratio Hospital stay Hospitalization Hospitalized hypertension hypertensive patient hypothese hypotheses inhibitor insurance Intubated limit lower risk Mortality Patient patients treated pharmacoepidemiology positive prevalent primary end point raise receptor renal risk treated [DOI] 10.1161/HYPERTENSIONAHA.120.16314 PMC 바로가기 [Article Type] Observational Study