Immunopathology of SARS-CoV-2 Infection: Immune Cells and Mediators, Prognostic Factors, and Immune-Therapeutic ImplicationsReview Published on 2020-07-062022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] “cytokine storm” Activation alteration Analysis antagonists blockers Blood purification cellular characterized Chloroquine Critical Cytokine storm Cytokines drugs Evolution glucocorticoid humoral IFN lambda IL-1 IL-6 immune Immune cell immune change immune reaction immune response immunoglobulins immunopathology Infection inflammatory parameters inhibitor inhibitors leukocyte lymphocyte mononuclear macrophage pathogen Prognostic factor Prognostic marker proliferation recruitment resistance mechanisms SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients stem cells subpopulations T lymphocyte the disease therapy TNF Tocilizumab variety virus [DOI] 10.3390/ijms21134782 PMC 바로가기 [Article Type] Review
Immediate and long-term consequences of COVID-19 infections for the development of neurological diseaseViewpoint Published on 2020-06-042022-10-28 Journal: Alzheimer's Research & Therapy [Category] COVID-19, SARS, [키워드] affected assisted ventilation Brain cause Cognition cognitive Cognitive impairment consequence Course COVID-19 COVID-19 case COVID-19 infection COVID-19 pandemic cytokine de novo Decline disease dysfunction Effect Evidence Factor higher risk Immediate immune reaction Increasing Infection less likelihood neurodegeneration neurodegenerative Neuroinflammation Neurological deficit Neurological disease Neurological symptom NLRP3 inflammasome Patient patients Proinflammatory cytokine proportion severity suggested systemic inflammation these symptom while [DOI] 10.1186/s13195-020-00640-3 PMC 바로가기 [Article Type] Viewpoint
Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A , -B and -C alleles10,000개 이상의 HLA-A, -B 및 -C 대립유전자 서열의 무작위 변이로부터 기능적 다형성 구별Research Article Published on 2017-06-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles amino-acid Analysis Antigen applicability binding site bone-marrow transplant bone-marrow transplants breadth common allele common alleles core alleles Defense determined by develop distinguishing domain Donor donors effort engage exponential growth Facilitating Families family family member Frequency functional Genetic variation glycoprotein growth HLA HLA class I HLA class I alleles HLA class I glycoproteins HLA complex HLA gene HLA genes HLA type HLA variation HLA-A HLA-B HLA-C HLA-C alleles homologous human gene human genes Human genome human population human populations immune functions immune reaction immune system genes incidence individuals Infection kill lymphocyte majority MOST Mutation mutation rate nucleotide nucleotides Older Patient peptide peptides Point mutation polymorphism populations Positive selection predict produced random receptors recombinant recombinants registries required selected sequence sequenced Sequencing Single nucleotide polymorphism single nucleotide polymorphisms Spread subject Substitution the patient variant variants Variation Viral viral infections [DOI] 10.1371/journal.pgen.1006862 PMC 바로가기 [Article Type] Research Article