A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2하이브리드 가용성 gp130/스파이크-나노바디 융합 단백질은 SARS-CoV-2로 인터루킨-6 트랜스-시그널링 및 세포 감염을 동시에 차단합니다Article Published on 2022-02-232022-09-12 Journal: Journal of Virology [Category] MERS, 진단, [키워드] acute respiratory syndrome addition age anti-inflammatory therapies antibody Antiviral approved assays bind block Cell Clinical use Comorbidities complexes Concentration coronavirus coronavirus disease COVID-19 cytokine receptor Cytokine storm diabetes disease pathology effective fused fusing fusion Glucocorticoid treatment high affinity higher risk hybrid hyperinflammation IL-6 IL-6 receptor IL-6R Immunocompromised patient individual induce infected individuals infected patients Infection inhibitor inhibitors intensive care interleukin-6 life-threatening Lung disease Mild monoclonal antibody monoclonal antibody treatment Multiorgan nanobody pandemic Patient patients Phosphorylation Prevent proliferation Protein RBD Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine severe COVID-19 sgp130 shown Signaling sIL-6R soluble IL-6R Spike protein STAT3 Symptoms symptoms of COVID-19 the SARS-CoV-2 the spike protein therapeutic options therapy trans-signaling trans-signaling. treat Vero cells viral cell viral infection virus-induced hyperinflammation [DOI] 10.1128/JVI.01622-21 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variantsResearch Article Published on 2022-02-142022-10-29 Journal: PLoS Pathogens [Category] COVID-19, COVID19(2023년), SARS, [키워드] alleles Allogeneic Anti-viral Antigen approach can be used Cell Complication convalescent individual Coverage COVID-19 Critical Effectiveness epitope Evidence expand functional generate healthy HLA HLA class I humans immune immune system Immunocompromised patient Immunotherapy increased risk individual leukocyte observation offer Patient phenotypic powerful tool provided recognize recognizing reduce remain unchanged Repository Research risk robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell screened selected severe complication severe COVID-19 susceptible T cell T cells T-cell T-cell Response target transfer treat Treatment Vaccines variant variants of SARS-CoV-2 viral disease viral infections virus-specific T cell while with COVID-19 [DOI] 10.1371/journal.ppat.1010339 PMC 바로가기 [Article Type] Research Article
Immunogenicity of COVID-19 mRNA vaccines in immunocompromised patients: a systematic review and meta-analysisReview Published on 2022-02-122022-10-31 Journal: European Journal of Medical Research [Category] COVID-19, [키워드] Analysis approach article Autoimmune autoimmune condition booster dose Control COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines COVID-19 vaccination dose Efficacy evaluate finding fixed General population healthcare healthy individual Hematologic malignancy heterogeneity higher risk identify Immunocompromised Immunocompromised patient immunogenicity Infection kidney malignancy Meta-analysis morbidity Mortality mRNA COVID-19 vaccine on type organ Patient patients positive proportion random recipient recipients Result risk SARS-CoV-2 searched Seroconversion severe SARS-CoV-2 significantly higher statistically significant supplementary material systematic review transplantation vaccination was performed Web of Science [DOI] 10.1186/s40001-022-00648-5 PMC 바로가기 [Article Type] Review
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individualsNK 세포 빈도, 기능 및 BNT162b2 mRNA 항 SARS-CoV-2 예방 접종을 받은 건강하고 면역이 약한 개인에서 백신 결과와 상관 관계Research Article Published on 2022-02-082022-09-12 Journal: Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive immune responses anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 mRNA vaccine Cancer characterized clinical material clinical trial Course COVID-19 Day description Effect EudraCT frequencies Frequency healthy healthy individuals immune cells immune response immune responses Immunocompromised immunocompromised individual Immunocompromised patient Immunocompromised patients in healthy individual Innate immune cells Innate immunity mRNA mRNA vaccination mRNA vaccine mRNA-based NK cell NK cells NKG2C non-randomized Open-label outcome Peripheral blood Phenotypes positive correlation preserved Prospective clinical trial Registered Result SARS-CoV-2 supplementary material Trial registration vaccination Vaccine vaccine trial viral infections [DOI] 10.1186/s10020-022-00443-2 PMC 바로가기 [Article Type] Research Article
Prolonged SARS-CoV-2 infection following rituximab treatment: clinical course and response to therapeutic interventions correlated with quantitative viral cultures and cycle threshold values리툭시 맙 치료 후 연장 된 SARS-COV-2 감염 : 정량적 바이러스 배양 및 사이클 임계 값과 관련된 치료 중재에 대한 임상 과정 및 반응Case Reports Published on 2022-02-052022-09-01 Journal: Antimicrobial Resistance and Infection Control [Category] COVID19(2023년), Fulltext, MERS, SARS, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antiviral therapies antiviral therapy approach B-cells clearance Clinical course Clinical parameters complex coronavirus correlated COVID-19 patient COVID-19 patients COVID-19 vaccination Cycle threshold value detection diagnostics highlight Immunocompromised patient Immunosuppressed Immunosuppression implication infection control Infection prevention maintenance nasopharyngeal swabs Oropharyngeal oropharyngeal or nasopharyngeal swabs parameters Patient PCR cycle Prevention and control Prolonged prolonged viral shedding Quantitative question raise recent respiratory reverse transcriptase risk factor RNA RT-PCR SARS-CoV-2 SARS-COV-2 infection Sequencing severe acute respiratory syndrome Coronavirus Steroids suggested supplementary material Therapeutic approach therapeutic intervention Therapeutics threshold vaccination Viral viral clearance viral culture viral shedding virus whole genome Whole genome sequencing [DOI] 10.1186/s13756-022-01067-1 PMC 바로가기 [Article Type] Case Reports
Case of atypical disseminated herpes zoster in a patient with COVID‐19: A diagnostic challenge in COVID eraCase Reports Published on 2022-02-022024-09-04 Journal: Clinical Case Reports [Category] 대상포진, [키워드] COVID‐19 herpes zoster Immunocompromised patient varicella zoster [DOI] 10.1002/ccr3.5342 PMC 바로가기 [Article Type] Case Reports
Third dose of anti-SARS-CoV-2 vaccine for patients with cancer: Should humoral responses be monitored? A position article암 환자를 위한 항 SARS-CoV-2 백신 3차 접종: 체액 반응을 모니터링해야 합니까? 입장 기사Review Published on 2022-02-012022-09-12 Journal: European journal of cancer (Oxford, England : 1990 [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition Administered anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 vaccines anti-spike antibodies antibody appear assist binding booster booster dose Cancer clinical trial Comorbidity COVID-19 death dosage dose Epidemic Evidence General population helping higher risk humoral Humoral response Immunocompromised patient incidence rates less mandatory monitoring oncologist outlined Patient patient population Patients with cancer recommendation SARS-CoV-2 Seroconversion serological severe coronavirus disease suggested Taking third dose titre undergo vaccination Vaccine waning immunity [DOI] 10.1016/j.ejca.2021.12.011 PMC 바로가기 [Article Type] Review
Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations: a systematic review면역 저하 집단에서 COVID-19 백신의 면역학적 및 임상적 효능: 체계적인 검토Review Published on 2022-02-012022-09-12 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-CD20 anti-SARS-CoV-2 antibodies Breakthrough infection Cancer case sery Clinical efficacy collected collected data Complete conducted COVID-19 COVID-19 vaccine defined dialysis dose effective Effectiveness Efficacy eligibility criteria evaluated Factor haematological malignancy highlight Hospitalization immune-mediated disease Immunocompromised Immunocompromised patient immunogenicity Immunosuppression immunosuppressive increased risk lack less malignancy non-responder observational studies Older age Participants Patient patients Patients with cancer patients with haematological populations recipient reduction in regimen risk SARS-CoV-2 SARS-CoV-2 immunocompromised SARS-COV-2 infection screened searched severe COVID-19 small sample size solid organ solid organ transplant Spike protein systematic review use of corticosteroids vaccination Vaccine were excluded [DOI] 10.1016/j.cmi.2021.09.036 PMC 바로가기 [Article Type] Review
Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro , despite Eliciting a Prolonged Antiviral ResponseResearch Article Published on 2022-01-182022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] absence Alpha Analysis Antiviral apical surface Apoptosis Atf3 basal cells Cell cell death cell type characterized contributing to COVID-19 COVID-19 patient DDIT3 disease Eliciting epithelia epithelial expression Factor gene signature host response Human Immune cell Immunocompromised patient infected NEC Infection interferon response investigated involved management nasal Nasal Epithelial cells NEC Necrosis Patient persistence persistent Postinfection Prolonged provide replicate Replication response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Signaling single-cell sequencing staining stress-related gene subset TNF-α transcriptome sequencing Transmission unique Viral antigen viral clearance Viral load viral persistence virus widespread [DOI] 10.1128/mbio.03436-21 PMC 바로가기 [Article Type] Research Article
Herpes Zoster Infection in an Immunocompromised Patient: A Case Report and Review of Corticosteroid’s Rolearticle Published on 2022-01-032024-09-02 Journal: Cureus [Category] 대상포진, [키워드] corticosteroid treatment herpes zoster virus Immunocompromised patient Immunosuppression viral infection [DOI] 10.7759/cureus.20908 PMC 바로가기 [Article Type] article