The evolution of powerful yet perilous immune systems강력하지만 위험한 면역 체계의 진화Review Published on 2022-02-012022-09-12 Journal: Trends in immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition benefit complement coronavirus disease COVID-19 cytokine Cytokines Defense Evolution Evolutionary biology example explain Goldilocks help immune responses immune system immunopathological immunopathology individual Infection mammalian natural selection optimality. predict resource responses suffered susceptibility symbiont [DOI] 10.1016/j.it.2021.12.002 PMC 바로가기 [Article Type] Review
Therapeutic implications of ongoing alveolar viral replication in COVID-19Review article Published on 2022-02-012022-10-05 Journal: The Lancet Rheumatology [Category] 변종, [키워드] alveolar approach autoimmune responses benefit blunting Corticosteroid COVID-19 Critical disease disease excessive inflammatory response heterogeneity highlight immunomodulatory therapy immunopathology Immunosuppression Immunotherapy immunothrombosis implication individual innate immune response interleukin-6 receptor Lungs Mild moderate-to-severe COVID-19 moderate-to-severe COVID-19 pneumonia Oxygen therapy Patient patients treated SARS-CoV-2 clearance SARS-CoV-2 replication T-cell responses therapeutic therapy thought Ventilation viral replication [DOI] 10.1016/S2665-9913(21)00322-2 [Article Type] Review article
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19단일 세포 다중 오믹스는 진행성 COVID-19에서 선천 면역 체계와 적응 면역 체계의 불일치를 나타냅니다.Article Published on 2022-01-212022-09-12 Journal: Nature Communications [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] activated adaptive adaptive immune system Analysis approach B cell CD8 Cell cellular cellular immunity classical monocyte classical monocytes clone clones Course COVID-19 Disease progression dysregulated immune response dysregulated immune responses Effect Frequency Gene Expression hallmark hallmarks highlight hospitalized patient hospitalized patients immune immune profiling immune response immune responses immune signature Immunity immunopathology information innate and adaptive immunity Interaction LAG-3 Lineage marker Monocytes mutated pathology patients patients with COVID-19 probe progressive COVID-19 progressive disease Protein reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 single-cell skewed Systems analysis T cell T cell receptor T cells the SARS-CoV-2 virus Tocilizumab viral infection [DOI] 10.1038/s41467-021-27716-4 PMC 바로가기 [Article Type] Article
Persistent Oxidative Stress and Inflammasome Activation in CD14 high CD16 − Monocytes From COVID-19 PatientsCOVID-19 환자의 CD14 높은 CD16- 단핵구에서 지속적인 산화 스트레스 및 염증 활성화Immunology Published on 2022-01-142022-08-31 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] addition caspase caspase-1 caused CD14 CD14highCD16− monocytes CD16 Cell contribute coronavirus coronavirus disease correlated COVID-19 dependent on disease severity displaying enrichment evidenced hallmark healthy controls hyperinflammation Hyperinflammatory IL-1β immunopathology implicated in vitro Inflammasome inflammasome activation lipid peroxidation Mild mitigate mitochondrial monocyte Monocytes NLRP3 NLRP3 inflammasome outcome outcomes oxidative oxidative stress oxidative stress response pathway Patient persistent response SARS-CoV-2 secretion severe COVID-19 patient severe COVID-19 patients signaling pathway Stress stress response stress responses Superoxide therapy [DOI] 10.3389/fimmu.2021.799558 PMC 바로가기 [Article Type] Immunology
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologyACE2는 TNF- 및 IFNγ-유도 면역병리학을 가진 새로운 COVID-19 마우스 모델에서 SARS-CoV-2에 대한 중요한 생체 내 수용체입니다Research Article Published on 2022-01-132022-09-12 Journal: eLife [Category] 진단, [키워드] ACE2 adaptive BALB/c C57BL/6 COVID-19 COVID-19 mouse model COVID-19 therapy Critical Cytokine storm dependent on disease severity Factor Genetic human disease IFNγ Immune cell infiltration Immunity immunological immunopathology in vivo inhibition Interaction lymphopenia maVie16 mice mouse mouse-adapted SARS-CoV-2 murine Mutation pathology Pneumonia prevented Proinflammatory cytokine receptor recombinant ACE2 recombinant soluble ace2 reduced replicated resulting SARS-CoV-2 spike therapy TNF Treatment [DOI] 10.7554/eLife.74623 PMC 바로가기 [Article Type] Research Article
Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology가용성 CD24를 사용한 치료는 COVID-19 관련 전신 면역병리를 약화시킵니다Clinical Trial Published on 2022-01-102022-09-12 Journal: Journal of Hematology & Oncology [Category] 임상, 진단, [키워드] acute respiratory syndrome coronavirus Analysis anti-inflammatory agent anti-inflammatory agents Anti-viral Antibody Response approach attenuate binding blunt cause CD24 CD24Fc CD4 CD56 CD8 cellular compartments chemokine chemokines Clinical characteristics Clinical efficacy coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity cytokine Cytokine score Cytokines damage damage-associated molecular pattern Damage-associated molecular patterns demonstrated downstream enrolled epithelial cells Extracellular flow cytometry heat shock proteins homeostasis homology Immune homeostasis immunopathology Immunophenotyping induce infected individuals Inflammatory response Lung epithelial cells Natural killer cells Pathogenesis pathway Patient patients with COVID-19 performed Peripheral blood peripheral blood samples phosphatase placebo group pro-inflammatory cytokine Protein Randomized Release respiratory Result return SARS-CoV-2 SARS-CoV-2-infected individuals severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity shown Siglec10 significantly Soluble CD24 supplementary material systemic cytokine response systemic inflammation T cell T cells therapeutic therapeutic efficacy Treatment Trial with COVID-19 [DOI] 10.1186/s13045-021-01222-y PMC 바로가기 [Article Type] Clinical Trial
A lethal mouse model for evaluating vaccine-associated enhanced respiratory disease during SARS-CoV-2 infectionResearch Article Published on 2022-01-072022-11-01 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory illness acute respiratory syndrome animal model BALB/c mice C57BL/6 caused characterized coronavirus description Diffuse alveolar damage Eosinophilic European immune response immunization immunopathology Infection Lineage mice Neutralizing antibodies neutralizing antibody pathogenesis of SARS-CoV-2 Pulmonary edema Recombinant spike protein Respiratory disease SARS-CoV-2 SARS-COV-2 infection T helper cell the disease Vaccine development vaccine-associated enhanced disease [DOI] 10.1126/sciadv.abh3827 PMC 바로가기 [Article Type] Research Article
Extracellular Vesicles and Cerebral Malariaarticle Published on 2021-12-312024-09-01 Journal: Subcellular Biochemistry [Category] 말라리아, [키워드] Exosomes Extracellular vesicles immunopathology malaria Microvesicles Neuro-immunlogy [Article Type] article
Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in miceNLRP3 인플라마좀의 특정 억제는 면역 과잉 활성화를 억제하고 생쥐의 병리와 같은 COVID-19를 완화합니다Article Published on 2021-12-312022-09-11 Journal: EBioMedicine [Category] SARS, 유전자 메커니즘, 진단, [키워드] activated Activation advance alleviate biosafety level BSL-3 Bureau C57BL/6 CAS Cell culture cell cultures conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 severity Cytokines education Evidence finding funding global public health histological host gene Host immune response human ACE2 immune immunofluorescence analysis immunopathology indicated inhibition inhibitor injected Intervention intranasally intraperitoneally Invasion involved knockout mice Laboratory level 3 live SARS-CoV-2 Lung inflammation lung tissue lung tissues Lungs macrophages MCC950 mice NLRP3 NLRP3 inflammasome pandemic pathology performed pro-inflammatory cytokine pro-inflammatory cytokines Program provided quantitative real-time PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, NLRP3 inflammasome, Immune overactivation, Cytokine storm Science severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients severe pathology severity Specific supported suppresse targeting THP-1 tissues transgenic mice Vaccine development Viral was reduced West wild-type with COVID-19 [DOI] 10.1016/j.ebiom.2021.103803 PMC 바로가기 [Article Type] Article
Complement activation induces excessive T cell cytotoxicity in severe COVID-19Article Published on 2021-12-282023-06-15 Journal: Cell [Category] COVID19(2023년), MERS, SARS, [키워드] complement COVID-19 cytotoxicity immunopathology T cells [DOI] 10.1016/j.cell.2021.12.040 PMC 바로가기 [Article Type] Article