The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular diseaseCardiovascular System & Vascular Biology Published on 2021-12-152022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, SARS, [키워드] ACE2 Activation acute respiratory syndrome alterations angiotensin converting enzyme 2 angiotensin-converting enzyme 2 antibody cause caused CD147 Cell cellular clinical response contributing to coronavirus COVID-19 death disease disrupt dysfunction elicited Endothelial cell events exposure to Extracellular Factor functional Hypothesis Implications in vitro induce infect infected patients Infection involved Ligand mechanism Microvascular damage Microvascular disease microvascular injury Migration mRNA neutralisation Patient pericyte Peripheral blood pro-apoptotic pro-inflammatory molecule Protein receptor recombinant S protein reduced rescued S protein SARS-CoV-2 secretion spike Spike protein stimulate Stress Support tested the cytokine storm the S protein the SARS-CoV-2 therapeutic variant Vascular wildtype [DOI] 10.1042/CS20210735 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
A data-driven approach to measuring epidemiological susceptibility risk around the worldArticle Published on 2021-12-152022-10-04 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] approach assessment consequence Contagion country data-driven Epidemics epidemiological event extreme Implications information Nonlinear phenomena organization outbreak PCA principal component analysis risk robust Scientific data Statistics susceptibility Variability [DOI] 10.1038/s41598-021-03322-8 PMC 바로가기 [Article Type] Article
Social Isolation, Loneliness and Generalized Anxiety: Implications and Associations during the COVID-19 QuarantineReview Published on 2021-12-082022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] Anxiety association COVID-19 COVID-19 pandemic Evidence Generalized Health heterogenous HPA Impact implication Implications locus loneliness mechanism morbidity Mortality nucleus quarantine social isolation Solutions [DOI] 10.3390/brainsci11121620 PMC 바로가기 [Article Type] Review
Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 InfectionSARS-COV-2 감염 후 아밀로이드 전구체 단백질 발현의 변화에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-12-012022-08-31 Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, meta-analysis, SARS, 유전자 메커니즘, [키워드] ACE2 Alzheimer’s disease amyloid amyloid precursor protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 app attachment base binding Blood–brain barrier Brain Brain microvascular endothelial cells canonical change complex COVID-19 COVID-19 disease elevated endothelial Endothelial cell endothelial cells enzyme expression followed by Host Host immune response host response identify IFNg IL1β IL6 immune response immune responses Implications incidence Infection Ingenuity Pathway Analysis inhibit inhibiting IPA knowledge base lead Meta-analysis modulated molecular mechanism molecular mechanisms molecules network Neuroinflammation neurological neurological manifestation p value pathway Protein Protein binding regulated Regulation reported resulting S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein Stat1 STAT3 statistically significant stroke TNF upstream were used with COVID-19 Z-score [DOI] 10.1007/s11481-021-10012-9 PMC 바로가기 [Article Type] Meta-Analysis
Rampant Increase in Cases of Mucormycosis in India and Pakistan: A Serious Cause for Concern during the Ongoing COVID-19 PandemicPerspective Piece Published on 2021-11-302022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, [키워드] cause Comorbidity concern COVID-19 COVID-19 pandemic COVID-19 patient Critical diabetes equipment Health highlight Implications increase increase in India intubation Mucormycosis oxygen pandemic reported steroid weakened immune system [DOI] 10.4269/ajtmh.21-0608 PMC 바로가기 [Article Type] Perspective Piece
Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans인간 곰팡이 병원체 암호화 코커스 데네 노모 인에서의 단성 재생산 동안의 동적 게놈 소성Research Article Published on 2021-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation addition Aneuploidy azole Cancer Cell cell cycle cell-cell fusion cells characterization characterized chromosome chromosomes concert conditions contributed copy number Critical Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cyclin cyclins defect detect differentially expressed diploid duplication dynamic early phase eukaryotic events Evidence evidence of Evolution example form fungal fungi generate genes encoding Genetic Genome hallmark haploid Host host infection Implications in some increase independent instance intrinsic isolates kinase kinases lead maintain maintenance mechanism meiosis meiotic mitotic molecular mechanism molecular mechanisms nourseothricin nuclear nuclear fusion occur organism Organisms pathogen pathway plasticity ploidy polyploid public health Regulatory reporter serotype sexual development survival uracil VAR Variation [DOI] 10.1371/journal.pgen.1009935 PMC 바로가기 [Article Type] Research Article
“A Question of Trust” and “a Leap of Faith”—Study Participants’ Perspectives on Consent, Privacy, and Trust in Smart Home Research: Qualitative StudyOriginal Paper Published on 2021-11-262022-10-31 Journal: JMIR mHealth and uHealth [Category] Coronavirus, MERS, SARS, [키워드] Abstract analyzed anonymization appear approach assist assistive technology Care compensated conducted Consent COVID-19 deleterious effect Environment experiment Factor Health Health services highlight home Human implication Implications information Informed consent interview involved maintain motivation objective observé offer participant Participants Perspective positive privacy Qualitative recorded recruited Research Research Ethics researcher Result sensor SmaRT smart homes Support the timing threat transcribed Trust unique University of Bristol variety was used [DOI] 10.2196/25227 PMC 바로가기 [Article Type] Original Paper
Effects of Emotional Expressiveness of a Female Digital Human on Loneliness, Stress, Perceived Support, and Closeness Across Genders: Randomized Controlled TrialRandomized Controlled Trial Published on 2021-11-252022-10-04 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 임상, [키워드] Affect analyses of variance average Care clinical closeness Community Complete computer agent conditions conducted Controlled COVID-19 pandemic develop Digital digital human Effect effective emotional emotional expressiveness evaluate exacerbated expression face facial female Gender greater group Health heart rate Human human-computer interaction Implications IMPROVE individuals Interaction Intervention loneliness men men and women Neutral New objective outcome outcomes Perceived physiological physiological responses Physiology Psychological public health reduce Registration registry Research Result shown significantly higher Social support Stress Support temperature user voice were assessed were measured women [DOI] 10.2196/30624 PMC 바로가기 [Article Type] Randomized Controlled Trial
Social media infodemics and social distancing under the COVID-19 pandemic: public good provisions under uncertaintyResearch Article Published on 2021-11-212022-10-31 Journal: Global Health Action [Category] Coronavirus, MERS, [키워드] COVID-19 COVID-19 pandemic Effect Effects ENhance examined Government Implications Infodemics information International organizations mechanism media public good public health risk aversion second social distancing social media [DOI] 10.1080/16549716.2021.1995958 PMC 바로가기 [Article Type] Research Article
Sleep Dysfunction in COVID-19 Patients: Prevalence, Risk Factors, Mechanisms, and ManagementReview Published on 2021-11-142022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Absolute lymphocyte count Anxiety applied consequence COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Depression Deprivation Duration dysfunction effective Effectiveness Evidence Factors Future greater high risk highlight Hospitalization hospitalized patients identify Implications infected individuals information Insomnia Intervention management mental health mental health concerns Neutrophil-to-lymphocyte ratio obstructive sleep apnea physical Population Prevalence Prevent proportion Protective Psychological Psychological distress Research risk Sleep sleep apnea Sleep disturbance sleep dysfunction Stress susceptibility viral infections [DOI] 10.3390/jpm11111203 PMC 바로가기 [Article Type] Review