Changes in Physical Activity Compared to the Situation before the Outbreak of COVID-19 in KoreaArticle Published on 2021-12-232022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] activities activity addition adjusted adopted adult female adult females age Analysis change changes in conducted COVID-19 develop diabete diagnosed difference educational status female Gender GLM greater hypertension inactive involved Korea community health survey Korean Koreans less male Model outbreak physical physical activity Result situation social distancing Sociodemographic spread of COVID-19 subject survey variables [DOI] 10.3390/ijerph19010126 PMC 바로가기 [Article Type] Article
Modulatory Effects of Physical Activity Levels on Immune Responses and General Clinical Functions in Adult Patients with Mild to Moderate SARS-CoV-2 Infections—A Protocol for an Observational Prospective Follow-Up Investigation: Fit-COVID-19 StudyProtocol Published on 2021-12-162022-10-04 Journal: International Journal of Environmental Research an [Category] SARS, 임상, [키워드] activity Adipose tissue analyzed approach baseline Biochemistry Blood blood sample body composition clinical collected conducted Control coronavirus coronavirus disease COVID-19 cytokine profile determine Effect evaluated Evidence exercise Exercise capacity explain expressed function functional healthy help homologous immune Immunity immunomodulatory in-vitro assay inactive individual Infection Inflammation Inflammatory information innate immune system knowledge Level long-COVID mechanism Mental mental health metabolic parameters metabolism Mild Moderate COVID-19 mononuclear cell obese participant Patient patients with COVID-19 PBMC PBMCs peripheral phenotypic physical physical activity physical activity level physically positive procedure Prospective prospective observational cohort provided Pulmonary function registry repeated-measures ANOVA Respiratory muscle strength respond response SARS-CoV-2 SARS-COV-2 infection Seahorse serum stimulated survival the SARS-CoV-2 virus the vaccine Trajectories treated vaccination venous viral infection virus [DOI] 10.3390/ijerph182413249 PMC 바로가기 [Article Type] Protocol
Physical Activity and Screen Time among Hungarian High School Students during the COVID-19 Pandemic Caused Distance Education PeriodArticle Published on 2021-12-102022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] activity Adults aerobic age ANCOVA Behavior BMI cardiovascular disease center changes in Cohort Control coronavirus COVID-19 decrease Decreased diabetes distance Distance education education Effect female Gender healthy lifestyle High School High school student Hungary inactive increase in increased risk indicated individual less lockdown majority male obesity pandemic Period physical activity public school reported SARS-CoV-2 pandemic School Screen screen time significantly student survey the WHO time took place was used Youth Z-score [DOI] 10.3390/ijerph182413024 PMC 바로가기 [Article Type] Article
Pre-Steady-State Kinetics of the SARS-CoV-2 Main Protease as a Powerful Tool for Antiviral Drug DiscoveryPharmacology Published on 2021-12-062022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] binding binding constant binding mechanism catalytically cleavage complex component Compound conformational conformational change COVID-19 drug Drug discovery effective Efficacy enzyme examined inactive induce inhibit inhibitor inhibitor binding interact Interaction investigated kinetic analysis kinetic mechanism Kinetics less M pro main protease molecular docking mutant peptide platform polyprotein pre-steady-state kinetics Quantitative responsible SARS-CoV-2 SARS-CoV-2 main protease Specific stopped-flow subsequent substrate cleavage the SARS-CoV-2 Treatment viral replication Virtual screening wild-type [DOI] 10.3389/fphar.2021.773198 PMC 바로가기 [Article Type] Pharmacology
Immunogenicity, safety and reactogenicity of a heterogeneous booster following the CoronaVac inactivated SARS-CoV-2 vaccine in patients with SLE: a case seriesSLE 환자에서 CoronaVac 비활성화 SARS-CoV-2 백신에 따른 이종 부스터의 면역원성, 안전성 및 반응성: 사례 시리즈Article Published on 2021-12-012022-09-12 Journal: RMD Open [Category] SARS, 진단, [키워드] Autoimmune booster booster dose case sery Cellular immune response CoronaVac country COVID-19 COVID-19 pandemic disease elicited Emergency use heterogeneous heterogenous humoral immune response immunogenicity Immunosuppressed immunosuppressive immunosuppressive medications IMPROVE inactivated Inactivated vaccine inactive initial lupus erythematosus mRNA Patient reactogenicity SARS-CoV-2 vaccination SARS-CoV-2 vaccine SLE Support systemic systemic lupus erythematosus therapy vaccination Vaccine Viral vector Viral vector vaccine [DOI] 10.1136/rmdopen-2021-002019 PMC 바로가기 [Article Type] Article
Impact of the SARS-CoV-2 pandemic and first lockdown on pregnancy monitoring in France: the COVIMATER cross-sectional studyResearch Published on 2021-11-302022-10-28 Journal: BMC Pregnancy and Childbirth [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition adjusted Care caused change changed conducted consequence coronavirus COVID-19 cross-sectional Delayed Deleterious Factors FIVE France French Health Impact inactive lockdown mother pandemic Pandemics Poisson regression model Pregnancy Pregnancy monitoring pregnant women prevalence ratio Probability professional reported Result robust SARS-CoV-2 supplementary material Support the disease the SARS-CoV-2 was used women [DOI] 10.1186/s12884-021-04256-9 PMC 바로가기 [Article Type] Research
Deep Learning Algorithms Achieved Satisfactory Predictions When Trained on a Novel Collection of Anticoronavirus MoleculesGenetics Published on 2021-11-292022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Achieved against SARS-CoV Algorithm Artificial neural network Collection COVID-19 dataset deep deep learning drug Drug discovery drug discovery and repurposing effort external validation FDA-approved drug forest graph graph convoluational networks inactive information learning machine learning molecule network novel positive rate prediction PubChem SARS-CoV-2 Screening Seven Structure Topic [DOI] 10.3389/fgene.2021.744170 PMC 바로가기 [Article Type] Genetics
Infection with SARS-CoV-2 causes flares in patients with juvenile idiopathic arthritis in remission or inactive disease on medicationSARS-CoV-2 감염은 소아 특발성 관절염 환자에서 완화 또는 약물 치료에 대한 비활동성 질환 환자에서 발적 유발Research Article Published on 2021-11-292022-09-12 Journal: Pediatric Rheumatology Online Journal [Category] MERS, SARS, 진단, [키워드] Adolescent Arthritis C-reactive protein cause center cohorts counseling Course COVID-19 database described disease ESR FIVE flare inactive infection with SARS-CoV-2 infections juvenile idiopathic arthritis medication occur Patient pediatric physician Remission Result rheumatic disease Rheumatic diseases SARS-CoV-2 searched subsequent Symptom treating Treatment Uveitis vaccination [DOI] 10.1186/s12969-021-00653-8 PMC 바로가기 [Article Type] Research Article
Statistical analysis plan for the Steppedwedge Cluster Randomized trial of Electronic Early Notification of sepsis in hospitalized ward patients (SCREEN)Randomized Controlled Trial Published on 2021-11-222022-10-04 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 95% confidence interval addition Alert Analysis analysis plan baseline Clinical data Cluster Clustering collected control group COVID-19 distribution Effectiveness electronic medical records EMR evaluate expressed facilitate fixed hospital hospital ward Hospitalized IMPROVE in-hospital mortality inactive include Intervention linear mixed model Mortality notification outcome analysis outcomes Patient patients patients with COVID-19 Primary outcome provide qSOFA random effect randomization Randomized randomized trial receive reduce Result risk Screening Sepsis sequence statistical Statistical analysis plan study period supplementary material Trial ward [DOI] 10.1186/s13063-021-05788-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 InfectionMedicine Published on 2021-11-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] accompanied acute respiratory syndrome autoantibody BC 007 Berlin capillary Case report caused CFS Characteristics chronic fatigue syndrome clinical Coronavirus disease 2019 Coronavirus-2 COVID-19 DNA fatigue feature functional functional GPCR autoantibodies Germany Glaucoma healthcare high affinity impairment inactivated inactive Infection long-COVID syndrome loss of taste management Mild neutralize observation observation period OCT angiography Patient peripapillary Physicians proinflammatory cytokines receptor remained SARS-CoV-2 suffered Symptom syndrome targeting tested the patient Treatment variety [DOI] 10.3389/fmed.2021.754667 PMC 바로가기 [Article Type] Medicine