Biallelic Mutations in NBAS Cause Recurrent Acute Liver Failure with Onset in InfancyNBAS의 이대립유전자 돌연변이는 유아기에 발병하여 재발성 급성 간부전을 유발합니다Report Published on 2015-07-022022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] acute infantile liver failure acute liver failure ALF Analysis biallelic mutation biallelic mutations cause childhood compound heterozygous mutation compound heterozygous mutations condition Endoplasmic reticulum Exome exome sequencing Fever fever-dependent RALF FIVE Golgi Immunoblot analysis individual infancy interaction partner involved life-threatening emergency liver liver failure molecular cause mutant fibroblast mutant fibroblasts NBAS Onset protein level RALF Recurrent reduced retrograde transport Sanger sequencing triggered [DOI] 10.1016/j.ajhg.2015.05.009 PMC 바로가기 [Article Type] Report
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article