Recovery of SARS-CoV-2 from large volumes of raw wastewater is enhanced with the inuvai R180 systeminuvai R180 시스템으로 대량의 원폐수에서 SARS-CoV-2 회수가 향상됨Article Published on 2022-02-152022-09-11 Journal: Journal of environmental management [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis applicability approach average circulation Community complement Concentration coronavirus 2 diarrhea early stage early stages effective epidemic diarrhea Epidemiology evaluate evaluated favor feature fiber filtration glycol groups inhibitory limits Limits of detection Methods performance and evaluation microbial outbreak overcome PEDV percentage plant Polyethylene glycol powerful tool Prevalence protocol quantification required SARS-CoV-2 scalability Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 Surveillance Treatment Usage Variability viral concentrations virus Volume wastewater Wastewater-based epidemiology water [DOI] 10.1016/j.jenvman.2021.114296 PMC 바로가기 [Article Type] Article
Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation †Review Published on 2022-02-132022-10-31 Journal: Cells [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE-2 adaptive angiotensin Apoptosis aryl Aryl hydrocarbon receptor AT1 binding boost build COVID-19 disease enzyme expression growth hydrocarbon IFN-I IL-6 immune tolerance Immunity Indolamine induce Inflammation Inflammatory Inflammatory response inflammatory state inhibitory innate response interferon Kynurenine limit management mechanism modulation Neutral pathogenic regulate respiratory Respiratory system role SARS-CoV-2 syndrome T cell target therapeutic target These data transporter Tryptophan type I [DOI] 10.3390/cells11040648 PMC 바로가기 [Article Type] Review
Case Report: A Peculiar Case of Inflammatory Colitis After SARS-CoV-2 Infection사례 보고: SARS-CoV-2 감염 후 염증성 대장염의 특이한 사례Case Reports Published on 2022-02-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료법, [키워드] alteration appear autoinflammatory response break Cell co-morbidity Colitis Colon COVID-19 cytotoxic immune cells death demonstrated died expected expressed expression healthy Hospitalization IHC immunological alterations increasingly Inflammatory inhibitory Interaction investigated Ligand lymphocyte marker morbidity mucosal necrotizing ulcerative colitis nucleocapsid protein Patient PD-1 PD-1/PD-L1 axis PD-L1 qRT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus self-tolerance the patient the SARS-CoV-2 virus tissue undetectable [DOI] 10.3389/fimmu.2022.849140 PMC 바로가기 [Article Type] Case Reports
Fast and Accurate Surrogate Virus Neutralization Test Based on Antibody-Mediated Blocking of the Interaction of ACE2 and SARS-CoV-2 Spike Protein RBDArticle Published on 2022-02-032022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] ACE2 ACE2 receptor amino acid substitution Anti-RBD IgG Beta variant blocking cellular complex convalescent plasma correlation decrease determine dilutions humoral IMPROVE Infection inhibit inhibitory Linear regression Live virus magnitude methodology neutralization neutralizing antibodies titers neutralizing antibody plate coating protective immunity quantification Randomly RBD reliability replaced Research S protein SARS-CoV-2 serum antibody serum samples soluble ACE2 spike surrogate sVNT sVNT assay Test the RBD the receptor-binding domain the S protein the SARS-CoV-2 variant virus virus neutralization test VNT was performed Wuhan-Hu-1 [DOI] 10.3390/diagnostics12020393 PMC 바로가기 [Article Type] Article
Lower Serologic Response to COVID-19 mRNA Vaccine in Patients With Inflammatory Bowel Diseases Treated With Anti-TNFα항-TNFα 치료를 받은 염증성 장 질환 환자의 코로나19 mRNA 백신에 대한 혈청학적 반응 감소Observational Study Published on 2022-02-012022-09-11 Journal: Gastroenterology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] administration adverse event adverse events AEs all subject all subjects Anti-spike anti-spike antibody anti-TNF antibody BNT162b2 booster dose comparable coronavirus disease COVID-19 dose doses drug level drug levels enrolled function functional groups HCs healthy control healthy controls high risk IBD infection rate infections Inflammatory bowel disease inflammatory bowel diseases inhibitory Lower magnitude Messenger RNA mounted mRNA mRNA-BNT162b2. multicenter Necrosis not affect Patient patients treated Pfizer Pfizer/BioNTech Prospective Prospective Study remained response Safe safety profile second dose serologic Serologic response serologic responses seronegative seropositive significantly lower stratified therapy TNFα treated treated patients Treatment Vaccine vaccine dose vaccine response vaccine responses [DOI] 10.1053/j.gastro.2021.10.029 PMC 바로가기 [Article Type] Observational Study
Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19낮은 수준의 과립구 골수 유래 억제 세포는 중증 COVID-19 환자의 추적 관찰에서 생존의 좋은 지표가 될 수 있습니다Observational Study Published on 2022-01-282022-09-12 Journal: Frontiers in Immunology [Category] 임상, 진단, [키워드] activated acute respiratory syndrome association cause Cell cells circulating contribute coronavirus coronavirus disease COVID-19 COVID-19 patients death develop died discharge discharged disease Endpoint Evolution examined Follow-up Good Granulocytic ICU immunological Immunosuppression Increased Infection inhibitory intensive care Level lymphocyte Lymphocytes MDSCs Mortality OX40 Pathogenesis Patient patients Patients with cancer PD-1 question raised SARS-CoV-2 SARS-CoV2 severe COVID-19 suppressor Tregs two group [DOI] 10.3389/fimmu.2021.801410 PMC 바로가기 [Article Type] Observational Study
Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approachArticle Published on 2022-01-272022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] 6LU7 approach approved baicalein binding free energy Care Compound Computational biology and bioinformatics COVID-19 docking Drug discovery FDA Health highly pathogenic Human identification indicated inhibitor inhibitors inhibitory Keeping M pro medication MM/PBSA molecular multiplex Polyozellus protease Protein researcher respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease therapeutic threat Treatment Vaccine Virtual drug screening Virtual screening was performed [DOI] 10.1038/s41598-022-05349-x PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models세포 배양 기반 감염 모델에서 새로운 퀴놀린 화합물의 항 SARS-CoV-2 억제 프로필Article Published on 2022-01-192022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] SARS, 치료제, [키워드] antiviral drug antiviral drug assessment Cell Cell culture cell culture-based infection models Compound compounds COVID-19 human SARS-CoV-2 Infection inhibitory Model morpholine morpholine-quinoline hybrids New pandemic profile quinoline quinoline compounds. SARS-CoV-2 SARS-CoV-2 infections selected Surveillance synthesis Vaccine Virological [DOI] 10.1002/chem.202103861 PMC 바로가기 [Article Type] Article
The chemical constituents of Sterculia comosa (wall) Roxb woods for arginase inhibitory, antioxidant activity, and molecular docking against SARS CoV-2 proteinResearch Article Published on 2022-01-192022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] Sterculia comosa (wall) Roxb. antioxidant arginase binding affinity docking DPPH flavonoid inhibitory inhibitory activity Interaction isolate methanol molecular docking Nsp12 PLPro predicted Protein SARS CoV-2 scavenging spike was determined [DOI] 10.1016/j.heliyon.2022.e08798 PMC 바로가기 [Article Type] Research Article
Predictive Factors for Neutralizing Antibody Levels Nine Months after Full Vaccination with BNT162b2: Results of a Machine Learning AnalysisArticle Published on 2022-01-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] age Analysis Antibody Response appear applied association Autoimmune disease BNT162b2 BNT162b2 mRNA vaccine body mass index category Characteristics Clustering COVID-19 Critical decrease Effect effective Factor factor analysis of mixed data feature FIVE had no identify individual inhibitory K-means clustering Level machine machine learning Month NAb NAbs Neutralizing antibodies neutralizing antibody nine older subjects participant PCA predict Principal component principal component analysis random Random forest Result SARS-CoV-2 subject subjects vaccination were used younger subject [DOI] 10.3390/biomedicines10020204 PMC 바로가기 [Article Type] Article