SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function
Research
[키워드] ACE2
activated T cells
acute respiratory syndrome
animal model
can be used
cause
coronavirus
driven by
enzyme
evaluate
evaluated
expressing
feature
Hospitalized
Human
immune
impaired function
Infection
infiltration
innate immune response
interferon signaling
K18
K18-hACE2
K18-hACE2 mice
leukocyte activation
Lung disease
lung tissue
Lungs
mice
Monocytes
neutrophil
nuclear
occur
other organs
Pathways
phenotype
promoter
Pulmonary function
receptor
SARS-CoV-2
SARS-COV-2 infection
Severe COVID-19 Infection
severe lung inflammation
spread to
to define
transgenic mice
type I
upregulated
viral infection
viral titer
[DOI] 10.1038/s41590-020-0778-2 [Article Type] Research
[DOI] 10.1038/s41590-020-0778-2 [Article Type] Research