COVID-19 vaccine development during pandemic: gap analysis, opportunities, and impact on future emerging infectious disease development strategies대유행 중 COVID-19 백신 개발: 격차 분석, 기회 및 미래의 신흥 전염병 개발 전략에 미치는 영향Article Published on 2021-04-032022-08-31 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 신약개발, [키워드] accelerated added addition addressed adjuvants Analysis COVID COVID-19 pandemic COVID-19 vaccine COVID-19 vaccine development Critical dosage dosage level effort Emerging infectious disease glassware GMP GMP manufacturing immune immune response Infectious disease Lipid nanoparticle Lipid nanoparticles long-lasting mRNA mRNA vaccine mRNA vaccines mRNA-lipid nanoparticle Neutralizing offer pandemic protective immune response provide regimen Safe stability Stress supply chains Vaccine Vaccine development vaccine dose Vaccines virus infectivity [DOI] 10.1080/21645515.2020.1822136 PMC 바로가기 [Article Type] Article
Addressing the Cold Reality of mRNA Vaccine StabilityArticle Published on 2021-03-012023-07-13 Journal: Journal of pharmaceutical sciences [Category] SARS, [키워드] cold chain COVID-19 Formulation Lipid nanoparticles mRNA shelf life stability Vaccine [DOI] 10.1016/j.xphs.2020.12.006 PMC 바로가기
Nanomedicine for COVID-19: the role of nanotechnology in the treatment and diagnosis of COVID-19Review Published on 2021-02-132022-10-31 Journal: Emergent Materials [Category] COVID-19, [키워드] acute respiratory syndrome approved benefit binding can be used caused component coronavirus Coronavirus 2019 CoV COVID-19 diagnose Diagnosis diagnosis of COVID-19 disease drugs effective encapsulation equipment facilitate Factor function globe greater healthcare worker investigated knowledge Lipid nanoparticles management MERS-CoV Middle East nanomedicine Nanoparticles Nanosensors Nanotechnology offer other diseases outbreak pandemic Pandemics performed pharmacological Replication Research respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus Stage therapeutic targets therapy treat Treatment vaccination Vaccine Viral diseases [DOI] 10.1007/s42247-021-00168-8 PMC 바로가기 [Article Type] Review
Lipid Nanoparticles as Delivery Systems for RNA-Based VaccinesReview Published on 2021-02-022022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] addition adjuvant Cancer Cancer immunotherapy cationic lipids clinical study Degradation delivery Delivery system Extracellular highlight immune response immunotherapies Infectious disease Lipid Lipid nanoparticles LNP mRNA mRNA-based vaccine nanoparticle Nanotechnology nucleic acid Rapid System target cell Vaccine Vaccines vector [DOI] 10.3390/pharmaceutics13020206 PMC 바로가기 [Article Type] Review
BNT162b vaccines protect rhesus macaques from SARS-CoV-2 Research Published on 2021-02-012022-10-05 Journal: Nature [Category] SARS, 비임상, 유전자 메커니즘, [키워드] Antibody Response BNT162b BNT162b1 BNT162b2 candidate candidate vaccine CD4+ COVID-19 disease domain dose dose-dependent effective elicit ENCODE evaluated Evidence full-length geometric mean titre Germany human ACE2 human sera immunize immunogen intramuscular Lipid nanoparticles Lower respiratory tract macaque Messenger RNA mice Phase I populations prefusion conformation proline PROTECT RBD residue rhesus macaque S glycoprotein Safe SARS-CoV-2 secreted spike glycoprotein T cell responses titre transmembrane Trial trimer vaccination Vaccine vaccine candidate Viral RNA [DOI] 10.1038/s41586-021-03275-y [Article Type] Research
Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid NanoparticlesArticle Published on 2021-01-222023-06-16 Journal: ACS Nano [Category] MERS, SARS, [키워드] COVID-19 Ionizable lipids Lipid nanoparticles mRNA vaccine SARS-CoV-2 [DOI] 10.1021/acsnano.0c10180 PMC 바로가기 [Article Type] Article
Advanced Nanobiomedical Approaches to Combat Coronavirus Disease of 2019Review Published on 2021-01-182022-10-28 Journal: Advanced Nanobiomed Research [Category] COVID-19, [키워드] acute respiratory syndrome addressed advancement approach approved benefit caused combat Contact coronavirus coronavirus disease COVID‐19 deaths effective vaccine Exosomes expand global pandemic inactivated viruses Infectious disease investigated Lipid nanoparticles nanomedicine New Novel coronavirus offer Particles populations Prevent produced producing provide regions Safe SARS‐CoV‐2 severe acute respiratory syndrome coronavirus 2 supportive care Therapeutics Transmission Travel treat Treatment Vaccine vaccine candidate Vaccines viruses while [DOI] 10.1002/anbr.202000063 PMC 바로가기 [Article Type] Review
Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infectionReview Published on 2020-12-132023-06-14 Journal: Advanced drug delivery reviews [Category] MERS, SARS, [키워드] adjuvant DNA vaccine Lipid nanoparticles mRNA vaccine polyplexes Protein and DNA Vaccine protein nanoparticles virus-like particles [DOI] 10.1016/j.addr.2020.12.006 PMC 바로가기 [Article Type] Review
COVID-19 and cancer: From basic mechanisms to vaccine development using nanotechnologyReview Published on 2020-12-022022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE acute respiratory syndrome administration affecting albumin Alter assist association Cancer cancer patient Cancer patients caused condition contribute coronavirus Coronavirus disease 2019 COVID COVID-19 COVID-19 vaccine distribution effective effective vaccine Effective vaccines Efficacy exacerbated faster global pandemic highlighting immune system Immunocompromised immunocompromised individuals Immunocompromised patient implementation Interaction lack limitation Lipid nanoparticles mechanism mortality rate mRNA vaccine Nanomaterial Nanotechnology Neutrophils pandemic Patient personalised Pharmaceutics Prevalence required SARS-CoV-2 show the vaccine Treatment Vaccine Vaccine development vaccine platform viral spike protein viral strains Viral vector virus [DOI] 10.1016/j.intimp.2020.107247 PMC 바로가기 [Article Type] Review
Recent advances in siRNA delivery mediated by lipid-based nanoparticlesReview article Published on 2020-08-062022-10-05 Journal: Advanced drug delivery reviews [Category] 비임상, [키워드] approval approved Bioavailability Blood Cancer Clinical use Degradation disease Diseases effective expected Genetic diseases Inflammatory intractable Lipid nanoparticles LNP Neurological disorder Patisiran pH-responsive ionizable lipid promote recent reported significantly siRNA Small interfering RNA Treatment unique viral infection [DOI] 10.1016/j.addr.2020.07.022 [Article Type] Review article