Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study코로나 바이러스 질병 환자의 간 기능 매개 변수의 동적 변화 2019 : 여러 센터, 후 향적 연구Multicenter Study Published on 2021-08-162022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Aalanine aminotransferase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine alanine aminotransferase albumin alkaline phosphatase ALP ALT aspartate Aspartate aminotransferase AST baseline Bilirubin change changes in chronic liver disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease died dynamic Dynamic changes Elevation elevations enrolled increase in Injury Inpatient Inpatients lead Liver function Liver function test liver function tests Liver injury multicentre parameter Patient phosphatase reported respiratory Result Retrospective study SARS-CoV-2 SARS-CoV-2 clearance severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increases in significantly increased total bilirubin Viral viral shedding [DOI] 10.1186/s12879-021-06572-z PMC 바로가기 [Article Type] Multicenter Study
Evaluation of hepatic enzymes activities in COVID-19 patients코로나19 환자의 간효소 활성 평가Article Published on 2021-08-012022-09-11 Journal: International immunopharmacology [Category] 바이오마커, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Alanine alanine aminotransferase alkaline phosphatase ALP ALT analyzed aspartate Aspartate aminotransferase AST Bilirubin Biomarker cause caused Characteristics clinical Clinical characteristics collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CRP disease enzyme activity enzyme tests Enzymes evaluate female hepatic enzyme hepatic enzymes IL-6 Inflammation Inflammatory biomarker inflammatory biomarkers Iraq Laboratory laboratory findings liver liver enzyme Liver function Liver function test male mechanism outbreak P-value Patient patients patients with COVID-19 phosphatase remained respiratory SARS-CoV-2 serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher Spread statistically statistically significant the patient total bilirubin virus virus replication was collected were measured [DOI] 10.1016/j.intimp.2021.107701 PMC 바로가기 [Article Type] Article
Regional Differences in Epidemiological and Clinical Characteristics, Treatment, and Clinical Outcomes of COVID-19 in Wuhan and Remote Areas of Hubei ProvinceMedicine Published on 2021-07-152022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] analyzed Area China clinical Clinical characteristics Clinical data Community conducted Coronavirus disease 2019 COVID-19 COVID-19 patient difference disease distribution epidemiological Fatality rate Final Follow-up glucocorticoid Health hospital incidence investigated Liver disease Liver function Mortality on mechanical ventilation outcome pandemic Patient Pneumonia proportion Region Regional regional differences remote resource Respiratory failure Retrospective cross-sectional study SARS-CoV-2 serum electrolyte Shock significantly higher Treatment union urban West Wuhan [DOI] 10.3389/fmed.2021.667623 PMC 바로가기 [Article Type] Medicine
Elevation of Serum Cytokine Profiles and Liver Metabolomic Normalization in Early Convalescence of COVID-19 PatientsMedicine Published on 2021-07-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addition alanine aminotransferase amino acid metabolism association B-cell change clinical manifestation convalescence convalescent phase Coronavirus disease 2019 correlations COVID-19 COVID-19 patient cytokine cytokine profile Cytokines decrease demonstrated discharged patient elevated Elevation functions global public health hospital discharge IFN-γ IL-10 IL-2 IL-4 IL-6 immune implication Injury interferon-γ lipid metabolism liver Liver function Liver injury liver repair metabolomic metabolomic analysis metabolomics normalization performed physiological effect profile profiles Retrospective study returned SARS-CoV-2 serum cytokine significantly supported T-cell Treatment tumor necrosis factor-α UPLC/Q-TOF-MS viral replication [DOI] 10.3389/fmed.2021.626633 PMC 바로가기 [Article Type] Medicine
Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed KidneysPharmacology Published on 2021-07-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] addition animal model blocked Cell cells CKD-chronic kidney disease Concentration COVID-19 determine downstream epithelial evaluated expression fibroblast fibrosis GS-441524 HK2 impairment in vitro in vivo inhibit inhibited injection intraperitoneal injection kidney kidneys knockdown Liver function marker mechanisms metabolite mice obstructed obstructed kidneys patients with COVID-19 RDV Remdesivir remdesivir (GS-5734) renal renal fibrosis staining stimulated TGF-β treat treated Treatment vehicle was increased were assessed were given were measured were used western blotting [DOI] 10.3389/fphar.2021.626510 PMC 바로가기 [Article Type] Pharmacology
Thrombosis at hospital presentation in patients with and without coronavirus disease 2019코로나바이러스 질환이 있거나 없는 환자의 병원 프레젠테이션에서 혈전증 2019Observational Study Published on 2021-07-012022-09-11 Journal: Journal of vascular surgery. Venous and lymphatic [Category] SARS, 바이오마커, 임상, [키워드] Admission age arterial or venous thrombosis Biomarkers blood count body mass body mass index C-reactive protein Coagulation Comorbidity complete blood count conducted coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients D-dimer levels Decline declines diagnosed disease Embolism ferritin greater hospital Hospitalization Hospitalized immunothrombosis increase in increased mortality Inflammation Inflammatory Ischemic Ischemic Stroke less Liver function Liver function test marker mechanism Mortality Myocardial infarction no difference no differences Outpatient outpatients Patient patients patients with COVID-19 proportion proportions reduce Retrospective analysis risk shift significant changes in significantly higher single-center stroke subtype the patient therapeutic target thrombosis thrombotic Thrombotic events Treatment Venous Thromboembolism Venous thrombosis with COVID-19 women [DOI] 10.1016/j.jvsv.2020.11.004 PMC 바로가기 [Article Type] Observational Study
COVID-19 and its effects on the digestive systemReview Published on 2021-06-282023-06-15 Journal: World journal of gastroenterology [Category] MERS, SARS, [키워드] COVID-19 digestive system endoscopy Inflammatory bowel disease Liver function mechanisms [DOI] 10.3748/wjg.v27.i24.3502 PMC 바로가기 [Article Type] Review
Dyslipidemia Is Related to Mortality in Critical Patients With Coronavirus Disease 2019: A Retrospective StudyEndocrinology Published on 2021-06-232022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] Admission Clinical outcome collected coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 Critical critical patient critical patients Diseases dyslipidemia hospital ICU intensive care Lipid lipid metabolism Liver function low density lipoprotein Lower metabolic disorder Mortality multiple organ dysfunction parameter Patient patients with COVID-19 profiles Prognosis progression remained renal function reported Result Retrospective study risk factor statistically suffered Total cholesterol treated was performed was related Wuhan Wuhan, China [DOI] 10.3389/fendo.2021.611526 PMC 바로가기 [Article Type] Endocrinology
COVID‐19 and the liver – Lessons learnedSupplement Article Published on 2021-06-212022-10-30 Journal: Liver international : official journal of the Inte [Category] COVID-19, MERS, SARS, [키워드] Activation Autoimmune Biochemistry Characteristics characterized cirrhosis coronavirus disease Course COVID‐19 Critical current cytokine production Cytopathic effect disease disease severity elevated Epidemiology Fatty liver hepatocyte high risk hospitalized patient hypoxic Immune cell Immunosuppressive medication include increase in indicated individual Inflammatory response lesson liver Liver damage Liver disease Liver function Liver function test Liver injury Liver transplantation marker mechanism outcome pathological mechanism Patient receiving severity stages susceptibility virus [DOI] 10.1111/liv.14854 PMC 바로가기 [Article Type] Supplement Article
Liver Impairment and Hematological Changes in Patients with Chronic Hepatitis C and COVID-19: A Retrospective Study after One Year of PandemicArticle Published on 2021-06-102022-10-30 Journal: Medicina [Category] COVID-19, MERS, SARS, [키워드] abnormality age alanine aminotransferase all-cause mortality analyzed C-reactive protein change chronic chronic disease Clinical outcome Cohort Complication conducted COVID-19 COVID-19 pandemic COVID-19 patients Follow-up greater HCV Hepatitis hepatitis C hepatitis C virus hospital impairment independent risk factor Infection intensive care liver Liver function liver impairment material mechanical ventilation mortality risk Multivariate analysis multivariate logistic regression objective outcomes P -value Patient patients with COVID-19 procalcitonin proportion public health emergency Replication required Result retrospective risk SARS-COV-2 infection severe COVID-19 Sex significantly higher single-center study Treatment Viral load with COVID-19 Year [DOI] 10.3390/medicina57060597 PMC 바로가기 [Article Type] Article