Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis호중구 세포외 트랩은 상피-중간엽 전환을 유도합니다: 코로나19 이후 섬유증에 미치는 영향Immunology Published on 2021-06-142022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] 16HBE A549 Air-liquid interface airway alveolar alveolar macrophage Analysis co-expression Complete Concentration COVID-19 Deceased demonstrated disease epithelial epithelial-mesenchymal transition expression pattern Factor highlight IL1β IL8 in vitro induce lung epithelial cell Lung fibrosis lung tissue marker mechanism NET NETosis NETs neutrophil Neutrophil extracellular trap pathogen Patient pneumocyte reactive SARS-CoV2 SARS-CoV2 infection secretion severe COVID-19 patient severe COVID-19 patients Spread subset TGF-β tissue injury [DOI] 10.3389/fimmu.2021.663303 PMC 바로가기 [Article Type] Immunology
Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular MechanismsReview Published on 2021-06-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activate activated Activation alveolar appear approved attenuate autophagy canonical Cell cell type cellular cellular proliferation change characterized clinical trial compassionate use Cytokines described disorders distribution Endoplasmic reticulum epithelial Evidence excessive inflammation expression FGF fibroblast fibrosis growth factor idiopathic pulmonary fibrosis (IPF) IL-11 IL-13 IL-6 ILD in vitro in vivo model indicate inhibit Interaction interstitial inflammation interstitial lung disease (ILD) isoform isoforms JAK inhibitor JAK/STAT JAK/STAT pathway JAK2/STAT3 Janus kinases (JAK) lung Lung disease lung disorder Lung fibrosis lung tissue molecular monoclonal antibody over-expressed pathway Pathways PDGF Phosphorylation predominant proliferation pulmonary fibrosis recent role SARS-CoV-2 virus signal transducer and activator of transcription (STAT) small molecule Stress TGF-β1 [DOI] 10.3390/ijms22126211 PMC 바로가기 [Article Type] Review
Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 PatientsArticle Published on 2021-06-022022-10-04 Journal: SLAS discovery : advancing life sciences R & D [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] 384-well format acute respiratory syndrome Analysis antifibrotic antifibrotic therapy Apoptosis application applied approved drug automated Autopsy Candidates Cell cell differentiation Confirmed COVID-19 COVID-19 pandemic COVID-19 patient current Data analysis Diseases drug ECM effective elevated Extracellular matrix fibroblast fibrosis growth hallmark Health high-content screening Human human lung lung Lung fibrosis medical need Middle East Migration mitigate Mortality network analysis pathway phenotypic phenotypic drug discovery previous study Prognosis proliferation Rapid representing repurposing respiratory disorder scarring screened Screening small molecule syndrome therapeutic Treatment ventilator with COVID-19 [DOI] 10.1177/24725552211019405 PMC 바로가기 [Article Type] Article
COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblastsInvited Review Published on 2021-05-242022-10-30 Journal: Immunological reviews [Category] COVID-19, SARS, [키워드] acute respiratory distress Affect Asymptomatic caused change China city COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 death develop disease epithelial cells feature fibroblast fibroblasts gastrointestinal systems implicated intensive care treatment interstitial knowledge lung Lung diseases lung epithelial cell Lung fibrosis lung remodeling many case mechanical ventilation occur pandemic pathway patients pulmonary fibrosis question Respiratory failure SARS‐CoV‐2 virus SARS‐CoV‐2 severity Spread Wuhan [DOI] 10.1111/imr.12977 PMC 바로가기 [Article Type] Invited Review
Screening for Sarcopenia (Physical Frailty) in the COVID-19 EraReview Article Published on 2021-05-212022-10-30 Journal: International Journal of Endocrinology [Category] COVID-19, [키워드] acute phase addition adequate diet adopted Adults Chronic disorder condition coronavirus disease COVID-19 COVID-19 crisis COVID-19 patient COVID-19 patients CT scanning current declined develop Diabetes Mellitus disorder DXA evaluated Hospitalization identify increase individual Lung fibrosis management measure morbidity and mortality Mortality MRI muscle muscle loss muscle mass Muscle strength muscular obesity Older Patient patients with COVID-19 physical physical activity poor prognosis Population populations Prevent proportion Protective Radiation recovering patients risk sarcopenia sarcopenic screened Screening social isolation symptomatic therapeutic intervention was measured weakness [DOI] 10.1155/2021/5563960 PMC 바로가기 [Article Type] Review Article
Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19Medicine Published on 2021-05-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] in vitro lung models acute respiratory distress affected alveolar alveolar epithelium alveolar regeneration ARDS assumed cause caused causing classical clinically collagen coronavirus coronavirus disease COVID-19 current DAD Diffuse alveolar damage disease ECM Effect Evidence Extracellular matrix fatal disease fibroblast in vitro in vitro model in vivo induce interstitial interstitial pulmonary fibrosis IPF knowledge lung Lung diseases Lung fibrosis lung organoids lung-on-chip mechanical stress molecular mechanism multicellular organoids Oxygenation pandemic Pathogenesis pathophysiological patients precision-cut lung slices proliferation Proteins pulmonary pulmonary fibrosis pulmonary impairment Pulmonary infection reduced respiratory SARS-CoV-2 SARS-COV-2 infection Symptoms syndrome tissue tissue regeneration treatment strategy Vaccine viral infections wound healing [DOI] 10.3389/fmed.2021.644678 PMC 바로가기 [Article Type] Medicine
Predicting lung fibrosis in post-COVID-19 patients after discharge with follow-up chest CT findingsResearch Published on 2021-05-032022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] Accuracy administration Admission age Analysis assigned average both group C-reactive protein Chest CT chest CT scan Clinical data Computed tomography Coronavirus infections COVID-19 COVID-19 infection cutoff point d -dimer Diagnosis discharge discharged discharged patient disease disease severity enrolled Factor feature fibrosis Follow-up Follow-up CT, Lung fibrosis follow-up time hospital Hospital stay HRCT ICU ICU admission include independent risk factor information initial Laboratory laboratory result LOS lowest Lung fibrosis lymphocyte management nasopharyngeal Novel coronavirus Patient patients positive post-COVID-19 patient predict pulmonary fibrosis Radiographic recorded required Result sensitivity Serum ferritin severity Sex specificity Spread statistically significant difference survived survivor tested two group was performed [DOI] 10.1186/s43055-021-00495-0 PMC 바로가기 [Article Type] Research
Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumoniaFra-2 전이성 마우스에서 폐 섬유증은 폐포 대식세포의 수 감소와 폐렴구균 폐렴에 대한 감수성 증가와 관련이 있다.Article Published on 2021-05-012024-08-24 Journal: American Journal of Physiology-Lung Cellular and Molecular Physiology [Category] 폐렴구균 감염증, [키워드] Bacteremia Idiopathic pulmonary fibrosis Lung fibrosis Pneumonia Streptococcus pneumoniae
Krebs von den Lungen 6 (KL-6) as a marker for disease severity and persistent radiological abnormalities following COVID-19 infection at 12 weeksKrebs von den Lungen 6(KL-6)은 12주에 COVID-19 감염 후 질병 중증도 및 지속적인 방사선 이상에 대한 마커입니다.Observational Study Published on 2021-04-292022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 임상, [키워드] abnormal CT scans abnormality absence acute COVID-19 acute infection acute respiratory distress acute respiratory distress syndrome Admission age ARDS association Asymptomatic baseline breathlessness cell injury clinical manifestation clinical manifestations Clinical severity Cohort Complication convalescent correlation COVID-19 infection CT scan CXR deconditioning determine disease severity Dyspnoea epithelial cell fibrosis finding Follow up appointment glycoprotein help hospital include Infection initial Injury Lung fibrosis male marker median medium mucin no significant difference observational study on admission oxygen Patient patients persistence presence or absence proportion Prospective pulmonary epithelial cell radiological abnormalities radiological abnormality Research question respiratory distress Respiratory distress syndrome Result severity significant difference significantly higher syndrome with COVID-19 [DOI] 10.1371/journal.pone.0249607 PMC 바로가기 [Article Type] Observational Study
Post-COVID-19 pneumonia lung fibrosis: a worrisome sequelae in surviving patientsResearch Published on 2021-04-132022-10-31 Journal: The Egyptian Journal of Radiology and Nuclear Medicine [Category] COVID-19, [키워드] age Analysis Cairo change changes clinical manifestation complications Computed tomography consequence COVID-19 COVID-19 infection develop drugs Early detection evaluated Factor fibrosis Follow-up lung Lung disease lung dysfunction Lung fibrosis mechanical ventilation modify Patient PCR Pneumonia post-COVID-19 Prevent processed Progressive pulmonary pulmonary fibrosis radiological Result serious complication severity smoking surviving patient Worrisome complication [DOI] 10.1186/s43055-021-00484-3 PMC 바로가기 [Article Type] Research