A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2
RESEARCH ARTICLE
[키워드] acute respiratory syndrome
animal model
Antibody-dependent enhancement
Combination
Complete
concentrations
conformational
coronavirus
COVID-19 convalescent patient
Cryo-electron microscopy
cryo-EM
determinant
domain
effective
Efficacy
elicited
epitope
Immune escape
immunization
immunized
immunogen
immunogens
Infection
injected
macaque
macaques
mitigate
monoclonal antibody
mononuclear cell
N-terminal domain
NAbs
neutralization potency
Neutralizing
Neutralizing antibodies
neutralizing antibody
neutralizing epitope
NTD
Peripheral blood
Protective
protective immune response
Protein
provided
RBD
RBD domain
RBD-targeting NAb
Receptor binding domain
Result
SARS-CoV-2
Screening
Spike protein
Structure
structure-based immunogen design
Vaccine design
Vaccine development
viral escape
[DOI] 10.1093/nsr/nwab053 PMC 바로가기 [Article Type] RESEARCH ARTICLE
[DOI] 10.1093/nsr/nwab053 PMC 바로가기 [Article Type] RESEARCH ARTICLE