A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa염색체 5q31.1 유전자좌는 동부 아프리카의 결핵 고 풍토병 지역에서 온 HIV 양성인 개인의 투베르쿨린 피부 검사 반응성과 연관됩니다.Research Article Published on 2017-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Active disease Airway inflammation Analysis approach association Author bacterium causal variant cause Cell chromosome chromosomes Cohort combined cohort complex cytokine detect determine develop dominant downstream Enrollment Evidence evidence of Genes Genetic genetic loci Genome-wide association study genome-wide significant Haplotype HIV-infection HIV-positive individual HIV-positive individuals identify IL9 Immunological response increase individual individuals infected individuals Infection Infectious disease Inflammation Inflammatory responses loci locus mast cell Mast cells Missense mutation missense variant Mycobacterium Mycobacterium tuberculosis Odds ratio participant Patient performed positive positive individuals power produced Prospective Study reactivity Region replicated risk significantly Skin test skin tests SLC25A48 subpopulation tested TST tuberculin skin test Tuberculosis Uganda uninfected unique variant variants [DOI] 10.1371/journal.pgen.1006710 PMC 바로가기 [Article Type] Research Article
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure심부전의 사망률과 관련된 염색체 5q22의 유전적 변이 발견Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting activate addition African allergic allergy applied approach assays association Asthma Blood Cell chemokine chemokines chromosome clinical trial clinical trials cytokine death dendritic cell dendritic cells determinant development DNA methylation ENhance enhancer region epigenomic Evidence evidence of expressing expression Factor failure Follow-up gene encode Genetic Genetic variant Genome-wide association studies Genome-wide association study genotyping heart heart failure HEK293 high mortality human cell human tissues identify increase increased risk independent induce inhibiting knockdown leads maintain Mast cells maturation Meta-analysis molecular Monocytes Mortality multiple tissues NHLH1 Patient performed polymorphism Population populations Positive selection predicted promote replicated reporter reporter gene responses risk allele subject T helper T-cell therapeutic Therapeutics Therapies transcription factor TSLP turn variant Whole blood [DOI] 10.1371/journal.pgen.1006034 PMC 바로가기 [Article Type] Research Article
Mast cell activation in the skin of Plasmodium falciparum malaria patients플라스모디움 팔시파룸 말라리아 환자의 피부에서 비만세포 활성화Research Published on 2015-02-072024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] malaria Mast cells Plasmodium falciparum skin toluidine blue stain [DOI] 10.1186/s12936-015-0568-8 PMC 바로가기 [Article Type] Research