Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study긴급 감염성 질환 프레젠테이션에서 COVID-19 및 기타 바이러스 감염을 구별하기 위한 3개 유전자 서명의 발견 및 검증: 사례 통제 및 관찰 코호트 연구Observational Study Published on 2021-11-012022-09-10 Journal: The Lancet. Microbe [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] 95% CI Admission Adults Analysis approach AUROC AUROCs Bacterial Bacterial infection Bacterial infections benefit Blood C-reactive protein C-reactive protein (CRP Case-control characteristic clinical utility Cohort COVID-19 COVID-19 infection COVID-19 infections criteria CRP decision curve analysis detect diagnoses diagnostic Emergency emergency department expressed Fever finding funding HERC6 hospital host gene host genes IGF1R individual Infection infections Infectious disease Infectious diseases initial lack leukocyte likelihood Medical Research Council NAGK no infection Observational cohort study pandemic participant Participants PCR-positive positive COVID-19 presenting receiver operating characteristic recruited RNA sequencing RT-qPCR SARS-CoV-2-positive participants sensitivities sensitivity signature Specificities specificity transcript transcriptional validation cohort Viral viral infection viral infections was done Wellcome Trust with infection [DOI] 10.1016/S2666-5247(21)00145-2 PMC 바로가기 [Article Type] Observational Study
Symptom Persistence Despite Improvement in Cardiopulmonary Health – Insights from longitudinal CMR, CPET and lung function testing post-COVID-19Research article Published on 2021-10-222022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, [키워드] abnormality Cardiopulmonary CMR comparable Control controls coronavirus disease COVID-19 CPET Department Ejection fraction fibrosis finding follow-up assessment foundation funding Health heart Hospitalised patients impairment IMPROVE improvement Infection Innovation insight ISRCTN Long COVID lung Lung function magnetic resonance imaging marker measure Measures Medical Research Council muscular National Native NIHR outcomes Oxford oxygen parenchymal abnormality Patient patients persistent PHOSP-COVID recruited reduced remained Research returned SARS-CoV-2 spirometry supported Symptom symptomatic trajectory United Kingdom ventricular Volume Wellcome Trust [DOI] 10.1016/j.eclinm.2021.101159 [Article Type] Research article
Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 SurvivorsBNT162b2-면역화된 SARS-CoV-1 생존자의 범-사베코바이러스 중화 항체Article Published on 2021-10-072022-09-11 Journal: The New England Journal of Medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody bat bats BNT162b2 caused coronavirus disease Effectiveness feasibility foundation Human human infection immunized Infection Medical Research Council Messenger RNA mRNA Neutralizing neutralizing antibody pangolin pangolins Prevent respiratory sarbecovirus Sarbecoviruses SARS-CoV-1 SARS-CoV-2 severe acute respiratory syndrome Coronavirus Singapore survivor Vaccine Vaccines variants of concern [DOI] 10.1056/NEJMoa2108453 PMC 바로가기 [Article Type] Article
A Web-Based Intervention (Germ Defence) to Increase Handwashing During a Pandemic: Process Evaluations of a Randomized Controlled Trial and Public Dissemination팬데믹 기간 동안 손 씻기를 늘리기 위한 웹 기반 개입(세균 방어): 무작위 대조 시험 및 공개 배포의 프로세스 평가Randomized Controlled Trial Published on 2021-10-052022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 비임상, 임상, [키워드] 95% CI adaptation affected attrition automated Behavior breath Cold colds Controlled coughing COVID-19 digital intervention dissemination dropped Effect Engagement Enrollment enrolment evaluation studies flu framework general practices Germ Guidance hands handwashing health emergency help increase Increases increases in Infection Influenza Intention Internet Intervention ISRCTN registry mean difference Medical Research Council objective Open Access outbreak pandemic participant Prevent prevention Process Public Randomized controlled trial RCT reached Registration replicated reported Research respiratory respiratory tract infection Respiratory tract infections respiratory viruses Result selected sneezing Spread swine flu Transmission Trial Usage user virus washing website [DOI] 10.2196/26104 PMC 바로가기 [Article Type] Randomized Controlled Trial
Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2Articles Published on 2021-10-012022-10-30 Journal: The Lancet. Child & adolescent health [Category] COVID-19, MERS, SARS, [키워드] 1:1 age analysed Analysis Anosmia approach artificial Asymptomatic cause Characteristics children children with COVID-19 Cohort college Council COVID COVID-19 Department determine Engineering Epidemiological study fatigue finding foundation funding Gender greater groups headache heart illness illness duration illness onset imaging Innovation intelligence IQR King Limited London median Medical Research Council mild illness Older pandemic participant persistent positive Prevalence prospective cohort study reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Science short duration Society Spearman Symptom symptom burden symptomatic Symptoms tested value Wellcome Trust were assessed were excluded [DOI] 10.1016/S2352-4642(21)00198-X PMC 바로가기 [Article Type] Articles
Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort StudyObservational Study Published on 2021-10-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] 6-minute walking distance addition adipose chest CT scan collected coronavirus disease diffusing European functional had more handgrip strength Health Assessment hospital hospital discharge ICU lung measure measurement mechanically ventilated Medical Research Council Month outcome pandemic Patient patients performance performed physical Physical disability predicted prospective observational cohort Pulmonary function Pulmonary function test severe coronavirus disease Skeletal muscle skeletal muscle injury survivor Survivors sustained tissue tissue area university walking distance was used weakness [DOI] 10.1097/CCM.0000000000005089 PMC 바로가기 [Article Type] Observational Study
Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic (IMPACCT COVID-19): protocol for a prospective, multicentre, mixed-methods cohort studyObservational Study Published on 2021-09-082022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] activity Admission adult intensive & Adults Affect analysed Anxiety approved assessment Care Chilean clinical cognitive Cognitive impairment cohort study Comorbidity COVID-19 COVID-19 pandemic Critical Critical care Depression determine disability discharge employment Ethics ethics committee European Functional status Health healthcare professionals ICU ICUs identify Impact independent Intensive intensive care intensive care unit interview Kaplan-Meier curves life mechanical ventilation media Medical Research Council Mental Montreal multicentre multiple imputation Muscle strength pandemic peer-reviewed performed physical post-traumatic professional Prospective protocol Quality Quality of life rehabilitation rehabilitation medicine scale schedule score semistructured interviews sensitivity analysis Seven severity status Stress survival survivor Survivors Symptoms variety WHO [DOI] 10.1136/bmjopen-2021-053610 PMC 바로가기 [Article Type] Observational Study
Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation studySARS-CoV-2 측방유동항원 검사의 비교 성능 및 임상 검체에서 감염성 바이러스 검출과의 연관성: 단일 센터 실험실 평가 연구Articles Published on 2021-09-012022-09-10 Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] alternative technology Analysis Antigen association B.1.1.7 B.1.1.7 variant be positive cassette clinical sample clinical samples collected Community Comparative comparison Comprehensive copy number cornerstone correlation COVID-19 Ct value Ct values Culture Department Device diagnostic diagnostic test disease severities dominant ENCODE evaluated except for family finding FIVE Fluorescence foundation funding Genotype greater group head Head-to-head comparison health-care help highest household contacts identify implementation infected individual infected individuals infectious sample Infectious virus Inpatient Inpatients King Laboratory Lateral lateral flow LFD limit of detection limitation London Longitudinal studies longitudinal study Medical Research Council naso-oropharyngeal swab not affected Outpatient outpatients PCR PCR cycle PCR testing PFUs plaque-forming unit positive Quantitative quantitative culture question raised ranged Rapid Rapid test real-time RT-PCR reduced RNA RT-rtPCR SARS-CoV-2 SARS-CoV-2 N gene SARS-CoV-2 testing selected sensitivities sensitivity Specificities specificity spring St Thomas' Hospital Support Surescreen Swab swabs Test test result tested Thoma threshold UK variant B.1.1.7 understanding Vero E6 VERO E6 cells Viral viral culture viral growth Viral RNA virus virus culture virus infectivity Wellcome Trust were assessed were used whole-genome sequencing [DOI] 10.1016/S2666-5247(21)00143-9 PMC 바로가기 [Article Type] Articles
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance프로테옴 전반에 걸친 유전자 조사는 임상 관련성이 있는 여러 SARS-CoV-2 악용 숙주 표적을 식별합니다.Research Article Published on 2021-08-172022-09-10 Journal: eLife [Category] MERS, SARS, 유전자 메커니즘, [키워드] ABO Accepted Affect affecting age Alpha Analysis Antiviral Apoptosis applied approach arising association Author cause CD209 clinical trial contribute COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 phenotypes datasets DC-SIGN death Demographic factors demonstrated disease severity evade explain Factor Factors funding Gender gene expression level gene mutation Genetic genetic colocalization genetic profile healthy individuals help Host host cells host protein host proteins Human identify identifying IL-6R immune immune response individual individuals infect Infection interact Interaction involved Karim MAK mechanism Medical Research Council mendelian randomization minor symptom minor symptoms molecular mutate natural experiment new strain no symptom no symptoms OAS1 open Open Access opens Patient patients with COVID-19 pleiotropic Potential treatment precursor predict predicted Probability PROTECT Protein Proteins proteome provide randomisation reaction receptor receptor protein reduce Research response responsible risk SARS-CoV-2 severe COVID-19 severity of COVID-19 SIGN Spike protein Strains submission susceptibility susceptible susceptible hosts Symptoms target targets the spike protein the strongest Therapeutics treat Treatment Trigger unique unit variety virus virus strains viruses Wellcome Trust with COVID-19 [DOI] 10.7554/eLife.69719 PMC 바로가기 [Article Type] Research Article
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: an interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial남아프리카에 HIV가 있거나없는 사람들의 SARS-COV-2에 대한 Chadox1 NCOV-19 (AZD1222) 백신의 안전성 및 면역 원성 : 무작위, 이중 맹검, 위약 대조, Phase 1B/2A 시험의 중간 분석Clinical Trial Published on 2021-08-172022-08-13 Journal: The Lancet. HIV [Category] MERS, SARS, 변종, 임상, 진단, [키워드] 1:1 1B/2A trial 95% CI adverse event adverse events African Alanine alanine aminotranferase allocation concealment Antibody Response Antibody Units Antiretroviral therapy Asp614Gly wild-type AZD1222 B.1.351 baseline Beta Beta variant binding antibodies binding antibody unit booster booster response both groups ChAdOx1 ChAdOx1 nCov 19 ChAdOx1 nCoV-19 clinical COV005 criteria cross-reactive binding antibodies cross-reactive binding antibody cross-reactivity D614G demonstrated died domain dose double-blind elevated eligibility criteria enrolled enrolment Fever finding FIVE foundation full-length funding geometric mean geometric mean concentration GMC high responder high responders High-level binding antibody HIV HIV-negative hospital IgG responses immunogenicity in both groups increased risk individual individuals Innovation interim analysis Intervention less Medical Research Council Melinda Gate Melinda Gates n=36 nCoV neutralisation Neutralising activity outcome Pan participant Participants people with HIV person with HIV Placebo placebo-controlled plasma Primary immunogenicity analyses Primary immunogenicity analysis prime-boost regimen priming priming dose randomised Randomly reactogenicity receive Receptor-binding domain Registered registry responses responses against retained rising Safety SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens Serious Adverse Events seronegative seropositive serum IgG Seven severe COVID-19 South South Africa titre Trial unlikely Vaccine vaccine dose Viral Viral load wild-type wild-type Wuhan-1 Asp614Gly with HIV [DOI] 10.1016/S2352-3018(21)00157-0 PMC 바로가기 [Article Type] Clinical Trial