Serological findings following the second and third SARS-CoV-2 vaccines in lung transplant recipients폐 이식 환자에서 2차 및 3차 SARS-CoV-2 백신에 따른 혈청학적 소견Article Published on 2022-08-012022-09-12 Journal: Immunity, Inflammation and Disease [Category] SARS, 진단, [키워드] acute respiratory syndrome age antibody Antibody titer average BBIBP-CorV booster Booster vaccine ChAdOx1 Clinical data coronavirus coronavirus disease COVID COVID-19 died difference dose doses effective enrolled evaluated had no highest ICU IgG immunization Immunocompromised patients Immunoglobulin Immunological response induce Infection injection intensive care lung transplant median men Messenger RNA mRNA mRNA vaccine mRNA-1273 mRNA-based non-mRNA vaccine pandemic Patient patients positive recipient SARS-CoV-2 SARS-CoV-2 vaccine second dose serology Serum level significantly higher STABLE Support therapy third vaccination Transplant U/mL Vaccine was measured were given [DOI] 10.1002/iid3.646 PMC 바로가기 [Article Type] Article
A case of coronavirus disease 2019 messenger RNA vaccine tolerance and immune response despite presence of anti-polyethylene glycol antibodies코로나바이러스 감염증 2019년 전령 RNA 백신 내성 및 항폴리에틸렌글리콜 항체 존재에도 면역반응 발생 사례Case Reports Published on 2022-08-012022-09-12 Journal: Annals of allergy, asthma & immunology : official [Category] MERS, 진단, [키워드] antibody coronavirus disease glycol immune response Messenger RNA Tolerance Vaccine [DOI] 10.1016/j.anai.2022.05.013 PMC 바로가기 [Article Type] Case Reports
Humoral and cellular responses to mRNA-based COVID-19 booster vaccinations in patients with solid neoplasms under active treatmentArticle Published on 2022-08-012022-10-05 Journal: ESMO open [Category] 진단, 치료법, [키워드] acute respiratory syndrome anti-spike antibody antibodies baseline BNT162b2 booster booster dose booster vaccination breakthrough infections Cancer cancer patient Cancer patients Care cause CD19+ CD4+ cell counts Cellular immune response cellular immunity cellular response Chemotherapy coronavirus COVID-19 COVID-19 infection died disease dose Efficacy Endocrine evaluated excluded exclusion criteria Factor Factors high risk high-risk population hospital humoral Humoral immunity immune response Immunosuppression immunosuppressive Infection Messenger RNA Mild mRNA mRNA vaccine mRNA-1273 mRNA-based neoplasm neutralizing antibody older patients Other outcome overcome Patient positive reduced required Result severe coronavirus disease significant increase significantly increased significantly lower solid malignancy solid tumors T-cell Response treated Treatment vaccination Vaccine vaccine dose Vaccines were assessed [DOI] 10.1016/j.esmoop.2022.100587 [Article Type] Article
Durability of Heterologous and Homologous COVID-19 Vaccine Boosts이종 및 동종 COVID-19 백신의 내구성 향상Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenovirus age Analysis Antibody Response Antibody responses Asian assays binding black BNT162b2 BNT162b2 vaccine boost Boston CD4+ T-cell CD8+ Cellular immune response cellular immune responses cohort study COVID-19 COVID-19 vaccine cytokine Data analysis declined elicited evaluate evaluated female Follow-up functional antibody response Heterologous heterologous prime-boost Hispanic homologous humoral humoral immune responses immune response immune responses immunization immunogenicity individual intracellular cytokine staining involved IQR Latino Massachusetts median Messenger RNA mRNA mRNA vaccine Neutralizing neutralizing antibodies titer neutralizing antibody occurred of BNT162b2 omicron outcome participant peaked potential benefit potential benefits prime-boost regimen rapid increase regimen repeated response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants T-cell responses These data Vaccine was performed were assessed white [DOI] 10.1001/jamanetworkopen.2022.26335 PMC 바로가기 [Article Type] Article
Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infectionOmicron BA.1 돌발성 감염 후 기존 교차 반응성 B 세포 기억 회상Article Published on 2022-07-292022-09-11 Journal: Science Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody Response B cell B cell memory B cell response Breakthrough infection characterized conserved coronavirus cross-reactive Donor donors facilitate feature Heterologous immune response immune responses immunodominance Infection memory B cells Messenger RNA Neutralizing antibodies neutralizing antibody omicron Preexisting immunity proportion RBD Receptor binding domain Recognition respiratory S2 subunit SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shift understanding Vaccines VOCs [DOI] 10.1126/sciimmunol.abq3511 PMC 바로가기 [Article Type] Article
Seroconversion rate after primary vaccination with two doses of BNT162b2 versus mRNA-1273 in solid organ transplant recipients: a systematic review and meta-analysis고형장기 이식 환자에서 2회 BNT162b2 대 mRNA-1273 1차 백신접종 후 혈청전환율: 체계적 고찰 및 메타분석Meta-Analysis Published on 2022-07-262022-09-12 Journal: Nephrology, dialysis, transplantation : official p [Category] MERS, 진단, [키워드] 95% CI acute respiratory syndrome antibody Antibody Response Antibody titer Antibody titers BNT162b2 calculate Cochrane Library confidence interval coronavirus described domain dose eligible General population indicate literature review Messenger RNA Meta-analysis mRNA mRNA vaccines mRNA-1273 of BNT162b2 Patient performed RBD recipient recipients reported Research SARS-CoV-2/COVID-19 seroconversion rate significantly higher solid organ transplant Solid organ transplant recipients SOT Spike protein systematic review the antibody response vaccination Vaccine was performed Web of Science [DOI] 10.1093/ndt/gfac174 PMC 바로가기 [Article Type] Meta-Analysis
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection Research Published on 2022-07-252022-10-05 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] alleviate approach can be used cathepsin L Cell CRISPR decrease expression Host host protease in vivo infected with SARS-CoV-2 inhibitor interstitial inflammation knockdown Lower lung Messenger RNA mice mRNA pathological changes Potential treatment Prevent proinflammatory protease reduced reported SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pathogenesis severity survival treat Treatment unique virus [DOI] 10.1038/s41589-022-01094-4 [Article Type] Research
Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article
BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age5~11세 어린이의 오미크론에 대한 BNT162b2 백신 효과Article Published on 2022-07-212022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age BNT162b2 BNT162b2 vaccine calculated Care children Cohort Control controls coronavirus coronavirus disease Coronavirus disease 2019 cumulative cumulative incidence dominant variant dose Effectiveness eligible European event Evidence first dose Health Health care incidence Infection Kaplan-Meier estimator Limited Messenger RNA moderate of BNT162b2 omicron Omicron variant outcome provided risk risk difference risk ratio RNA vaccine SARS-CoV-2 SARS-COV-2 infection second dose severe acute respiratory syndrome Coronavirus study group study groups study period subgroups symptomatic COVID-19 the study group the vaccine union Vaccine vaccine doses Year [DOI] 10.1056/NEJMoa2205011 PMC 바로가기 [Article Type] Article
A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 MiceRBD 60-mer 나노입자를 암호화하는 mRNA 백신은 형질전환 K18-hACE2 마우스에서 SARS-CoV-2 Delta 변이체에 대한 중화 항체 및 보호 면역을 유발합니다Article Published on 2022-07-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Against Antigen COVID-19 pandemic Delta delta variant displaying domain effective elicit encoding flexible hACE2 K18-hACE2 messenger Messenger RNA mRNA mRNA vaccine nanoparticle Neutralizing neutralizing antibody Neutralizing antibody response platform protective immunity provide RBD RBDs Receptor binding domain Receptor-binding domain RNA vaccine robust SARS-CoV-2 SARS-CoV-2 variant severe disease Spread the RBD the SARS-CoV-2 Transgenic mouse Vaccine [DOI] 10.3389/fimmu.2022.912898 PMC 바로가기 [Article Type] Article