Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severityResearch article Published on 2022-07-082022-10-05 Journal: Cell Systems [Category] 바이오마커, 치료기술, [키워드] age Analysis Butyrate Cell central metabolism Clinical outcome Comorbidities coronavirus disease COVID-19 COVID-19 severity determinant Digital disease severity explained fatality flow cytometry heterogeneous highlight identify Immune cell indicated metabolic metabolite metabolomics monocyte mononuclear phagocyte pathway personalized genome-scale metabolic model Perturbation plasma metabolomics progression quantification RNA sequencing severe COVID-19 severity similarity network fusion SLC16A6 SLC29A1 System biology TCA cycle the disease Treatment Whole blood with COVID-19 [DOI] 10.1016/j.cels.2022.06.006 [Article Type] Research article
Long COVID and long chain fatty acids (LCFAs): Psychoneuroimmunity implication of omega-3 LCFAs in delayed consequences of COVID-19Review article Published on 2022-07-012022-10-05 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 바이오마커, [키워드] accelerate accumulating acute respiratory syndrome addition Brain changes in chronic inflammation CNS Coagulation system Cognition Complication consequence coronavirus coronavirus disease COVID COVID-19 Depression disorder dysfunction dysregulated Effect EPA Evidence Fatty acid favorable effect heterogeneous HPA Immunity Impact Inflammation Intervention Long Long COVID mechanism metabolite metabolites modulating molecular mechanism mood multifactorial n-3 PUFAs Neuropsychiatric neurotransmitter offer omega-3 omega-3 PUFA Omega-3 PUFAs oxidative stress pandemic Polyunsaturated pro-inflammatory cytokines Prophylaxis Psychosocial stress PUFAs reducing SARS-CoV-2 SARS-COV-2 infection shown Sickness Spread Stage systematic review systemic inflammation tissue damage tissue homeostasis [DOI] 10.1016/j.bbi.2022.04.001 [Article Type] Review article
Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infectionsSARS-CoV-2 감염의 동반 질환 관련 단백질에 대한 Momordica dioica의 예측 의약 대사 산물Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ADME angiotensin angiotensin converting enzyme antidiabetic Antiviral binding binding affinities Blood brain barrier cardiovascular disease catechin comorbid comorbid condition comorbid conditions Comorbidity Compound correlated DDP4 diabetes dipeptidyl peptidase docking score DPP4 drugs enzyme exhibited Favipiravir flavonoid flavonoids gastrointestinal tract hederagenin Human Hydroxychloroquine immune immunomodulatory activities in silico in vitro investigated involved kidney ligands metabolite molecular molecular docking Momordica Momordica dioica oleanolic acid plant predicted protease Proteases Protein quercetin RdRP receptor reflect Remdesivir reported RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 main protease significant interaction Spike protein the SARS-CoV-2 therapeutic viral entry viral proteases [DOI] 10.1080/07391102.2020.1868340 PMC 바로가기 [Article Type] Article
Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats임신한 쥐에서 항바이러스성 렘데시비르와 주요 대사산물인 GS-441524의 생체변환 및 태반 전이Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] 치료제, [키워드] amniotic Amniotic fluid Anti-viral approved AUC Biotransformation Blood Blood-placental barrier C max coronavirus disease Coronavirus disease 2019 COVID-19 cross during pregnancy evaluated fetus GS-441524 Hypothesis Liquid chromatography mass spectrometry maternal blood metabolite Microdialysis MONITOR mother multisite nucleoside parameter pharmacokinetic pharmacokinetics Placenta placental barrier predominant Pregnancy pregnant RATs Remdesivir Science shown Taiwan Tandem mass spectrometry technology tissues transfer treat Treatment UHPLC was used while [DOI] 10.1016/j.ebiom.2022.104095 PMC 바로가기 [Article Type] Article
Diagnosis and prognosis of COVID-19 employing analysis of patients’ plasma and serum via LC-MS and machine learningLC-MS 및 머신러닝을 통한 환자의 혈장 및 혈청 분석을 통한 코로나19 진단 및 예후Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Accuracy acetyl Algorithm Analysis analyzed best Biomarker Biomarkers caused China controls COVID COVID 19 COVID-19 COVID-19 diagnosis COVID-19 patient datasets Diagnosis evaluate evaluated fatality glucosamine greater healthy volunteer healthy volunteers help hospital independent l-ornithine LC-MS machine machine learning material metabolite methyl isobutyrate negative RT-PCR outcomes Patient patients with COVID-19 patients with pneumonia phosphate plasma Pneumonia predict Prognosis prognostic indicator RT-PCR Sample SARS-CoV-2 serum severity significantly SVM the disease uridine virus viruses were used with COVID-19 [DOI] 10.1016/j.compbiomed.2022.105659 PMC 바로가기 [Article Type] Article
PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID-19 patientsPF-07321332(니르마트렐비르)는 인간 ENT1 또는 ENT2와 상호작용하지 않음: COVID-19 환자에 대한 시사점Article Published on 2022-07-012022-09-11 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 치료제, [키워드] acute lung injury antivirals bind Biotransformation Clinical efficacy clinical trials contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient death downregulation drug Efficacy EIDD-1931 Emergency use authorization Endothelial cell ENT ENTs expression Factor FDA food greater hypoxia in vitro inhibitor Interaction investigated lung epithelial Lung injury Lungs metabolite molnupiravir Nirmatrelvir nucleoside nucleoside analog nucleoside analogs pandemic Patient patients with COVID-19 PF-07321332 protease Protease inhibitor reflected Remdesivir Replication repression SARS-CoV-2 Severe acute respiratory syndrome shown substrate substrates the SARS-CoV-2 undergo unlikely US Food and Drug Administration viral replication Viral RNA Virology [DOI] 10.1111/cts.13292 PMC 바로가기 [Article Type] Article
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2뉴클레오사이드/뉴클레오타이드 유사체 테노포비르와 엠트리시타빈은 SARS-CoV-2에 대해 비활성입니다Article Published on 2022-06-302022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerated active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity antiviral agent Antiviral agents Antiviral effect approaches approved approved drug biochemical causative pathogen caution Cell clinicians and researcher Concentration coronavirus COVID-19 COVID-19 pandemic demonstrated Efficiency emtricitabine epithelial FTC HIV-1 HIV-1 NRTI human lung in vitro data inactive indicate inhibitor lack metabolite NHBE NTP nucleoside polymerase Prevent RdRP RdRp active site required reverse transcriptase RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus TAF TDF tenofovir Tenofovir alafenamide the SARS-CoV-2 transcriptase treat unlikely [DOI] 10.3390/molecules27134212 PMC 바로가기 [Article Type] Article
Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific DysregulationCOVID-19 발병 시 대사 프로파일링은 질병의 심각성과 성별에 따른 조절 장애를 보여줍니다Article Published on 2022-06-302022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Affect Amino acid among others can be used capillary electrophoresis change chemokine chemokines correlation COVID-19 COVID-19 patient COVID-19 severity cross-sectional study cytokine cytokine profile Cytokines deregulated disease disease onset Disease progression disease severity dysregulated dysregulation Early detection energy Evolution explain expression pattern gas chromatography GC-MS healthy controls highest Hospital admission identify L-kynurenine L-tryptophan later phase marker mass spectrometry material metabolic metabolic pathway metabolism metabolite metabolites metabolomics moderate molecular multiple organ multiple organs nitrogen Onset Pathogenesis Patient patients performed plasma powerful tool predict pro-inflammatory biomarker profile Profiling Prognosis reported Retrospective cross-sectional study SARS-COV-2 infection severity sex-specific. show shown Spanish Spanish hospitals stratified the SARS-CoV-2 [DOI] 10.3389/fimmu.2022.925558 PMC 바로가기 [Article Type] Article
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesisSARS-CoV-2는 활성화된 뉴클레오티드 합성에 대한 염증 반응의 회피를 결합합니다Article Published on 2022-06-282022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activate activated acute respiratory syndrome acute respiratory syndrome coronavirus aerobic aerobic glycolysis Antiviral antivirals aspartate CAD cellular coronavirus de novo deamidation deplete dihydroorotase effective enzyme evidenced Genetic changes Glycolysis highlighting host immunity Inflammatory Inflammatory response inhibitor metabolism metabolite metabolites NF-κB NF-κB activation Nsp9 nucleotide offer pressure promote provide pyrimidine RELA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subsequent targeting up-regulate Vaccinations variant Waves while [DOI] 10.1073/pnas.2122897119 PMC 바로가기 [Article Type] Article
Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain백신 유도 생식계열 인코딩 인간 항체의 구조는 SARS-CoV-2 스파이크 N-말단 도메인에서 중화 에피토프를 정의합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity Affinity maturation Alpha antibody Antigen arms race B cell B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biliverdin bind binding Cell cognate antigen complementarity-determining region complex conserved coronavirus cryo-EM Donor electron microscopy engage epitope evolutionary arms race Genetic germ line HCDR3 heme high-resolution structure Host Human hydrophobic Infection intermolecular interaction intermolecular interactions knowledge mAb maintain metabolite monoclonal monoclonal antibodies monoclonal antibody mRNA vaccination N-terminal domain neutralize Neutralizing NTD pathogen plasmablast plasmablasts provide respiratory responses reveal SARS-CoV-2 SARS-CoV-2 spike sequence severe acute respiratory syndrome Coronavirus shown spike spike glycoprotein Structure the SARS-CoV-2 the vaccine undergo vaccination Vaccine vaccine immunogen variant variants Viral viral strain viral variant Viral variants [DOI] 10.1128/mbio.03580-21 PMC 바로가기 [Article Type] Article