Metabolic Snapshot of Plasma Samples Reveals New Pathways Implicated in SARS-CoV-2 PathogenesisArticle Published on 2022-03-042023-07-08 Journal: Journal of Proteome Research [Category] COVID19(2023년), [키워드] Biomarkers clinical progression COVID-19 disease susceptibility metabolites metabolomics oxidative stress response. SARS-CoV-2 [DOI] 10.1021/acs.jproteome.1c00786
Untargeted detection of the carbonyl metabolome by chemical derivatization and liquid chromatography-tandem mass spectrometry in precursor ion scan mode: Elucidation of COVID-19 severity biomarkersResearch article Published on 2022-03-012022-10-05 Journal: Analytica chimica acta [Category] SARS, 바이오마커, 치료기술, [키워드] accelerate alteration Analysis approach Biomarker Biomarker discovery Biomarkers Carbonyl metabolome Compound COVID-19 COVID-19 severity demonstrated detect gold standard information Liquid chromatography-tandem mass spectrometry m/z metabolites metabolome metabolomics Perspective plasma plasma sample precursor Precursor ion scan selected severity Structure Untargeted metabolomics was selected with COVID-19 [DOI] 10.1016/j.aca.2021.339405 [Article Type] Research article
COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19Review Published on 2022-02-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] addressed adopted biochemical COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 research COVID-19 signature COVIDomics Data integration Diagnosis Disease progression drug target discovery dysregulated effort human cells include Infection knowledge mechanism metabolites metabolomics multiomics mutations pandemic pathophysiological pathway Perspective Proteins proteomics provided Replication Research SARS-CoV-2 Scientific community signature Spread the SARS-CoV-2 therapeutic Vaccine [DOI] 10.3390/ijms23052414 PMC 바로가기 [Article Type] Review
Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and PharmacodynamicsCOVID 폐렴에서 정맥내 나파모스타트 메실레이트의 무작위 대조 시험: 안전성, 약동학 및 약력학을 조사하기 위한 1b/2a상 실험 연구Clinical Trial Published on 2022-02-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% CI Administered adverse events Analysis Anti-inflammatory Anticoagulant anticoagulant effect anticoagulant effects antiviral activity assigned average characterisation Controlled trial COVID COVID-19 COVID19 creatinine credible interval demonstrated dose Edinburgh Endpoint endpoints Evidence evidence of Hospital stay hospitalised hospitalised patient Hospitalised patients inactive independent Infectious diseases intravenous intravenous infusion manuscript maximum mean difference mesylate metabolites nafamostat Nafamostat mesylate observé Odds ratio open open label Oxford oxygen Patient patients Pharmacodynamics pharmacokinetics phase Phase 2 PK data plasma platform Pneumonitis Primary outcome Primary outcomes progressed randomised randomised controlled trial Randomly rate ratio receive reported Repurposed drug Research respiratory Respiratory medicine response SARS-CoV-2/COVID-19 Seven significantly higher significantly more SOC Standard of care statistically significant difference therapy Tolerability Total Total manuscript word count. Trial university with COVID-19 [DOI] 10.1016/j.ebiom.2022.103856 PMC 바로가기 [Article Type] Clinical Trial
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다Article Published on 2022-01-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제, [키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids Analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread [DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article
Chaetomugilins and Chaetoviridins—Promising Natural Metabolites: Structures, Separation, Characterization, Biosynthesis, Bioactivities, Molecular Docking, and Molecular DynamicsReview Published on 2022-01-272022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] analyzed Antiviral binding energy bioactivities Biosynthesis Chaetomaceae chaetomugilins chaetoviridins characterization complexes Course COVID-19 crystal structure docking docking score docking study Dynamics evaluated exhibited feature fungal fungi generate inhibitor investigated metabolite metabolites molecular molecular docking natural oxygenated PDB Predictive produced protease reported Research separation stability structures the SARS-CoV-2 therapeutic agents unique [DOI] 10.3390/jof8020127 PMC 바로가기 [Article Type] Review
Integration Analysis of Pharmacokinetics and Metabolomics to Predict Metabolic Phenotype and Drug Exposure of RemdesivirPharmacology Published on 2022-01-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adenosine Administered Analysis AUC Biomarker blood sample C max change collected Comprehensive Concentration conducted correlated correlation Correlation analysis COVID-19 drug drug exposure evaluated Evidence exposure integration intravenously investigated metabolic metabolite metabolites metabolomics multivariate Nuc offer pharmacokinetics pharmacological PK parameter Potential biomarker precision therapy predict predicted RAT Remdesivir responders SARS-CoV-2 significantly spermine statistical analysis Toxicity Treatment Variation [DOI] 10.3389/fphar.2021.779135 PMC 바로가기 [Article Type] Pharmacology
SARS-COV-2 vaccination with BNT162B2 in renal transplant patients: Risk factors for impaired response and immunological implications신장 이식 환자에서 BNT162B2를 사용한 SARS-COV-2 백신 접종: 반응 장애 및 면역학적 영향에 대한 위험 요소Article Published on 2022-01-012022-09-11 Journal: Clinical transplantation [Category] MERS, SARS, 진단, 치료기술, [키워드] age Analysis antibody best BNT162b2 BNT162b2 vaccine coronavirus COVID-19 COVID-19 vaccination de novo Efficacy Factor Follow-up follow-up period graft rejection higher risk HLA-DSA immunological implication Infection intensity Italy kidney kidney transplant Kidney transplantation lack median metabolite metabolites Mild mRNA mRNA-based COVID-19 vaccine multivariable logistic regression Multivariable logistic regression analysis Organ transplant outcome Outpatient Patient patient age patients Post-vaccine pre-vaccination receiving rejection renal reported Rome SARS-CoV-2 Seroconversion seroconversion rate Solid solid organ solid organ transplant solid organ transplant patients. vaccination Vaccination strategy vaccine dose younger patient younger patients [DOI] 10.1111/ctr.14495 PMC 바로가기 [Article Type] Article
Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcomeCOVID-19 환자 혈청의 비표적 대사체학은 심각성과 결과 모두의 잠재적인 예후 마커를 나타냅니다Original Article Published on 2021-12-202022-09-10 Journal: Metabolomics [Category] SARS, 바이오마커, 치료기술, [키워드] among others Analysis approach Bayesian Bayesian logistic regression model blind capture Cohort COVID-19 COVID-19 patient COVID-19 patient serum cross Deceased deoxycytidine diagnosis of COVID-19 discharged energy metabolism high resolution Hospital admission Host host inflammatory response host response include infected individual infected individuals Infection Kynurenine LC–MS/MS Orbitrap logistic regression model marker metabolism metabolite metabolites metabolomics Mild nucleic acid objective outcome Patient patient treatment Planning positive predict predicted Predictive predictor profile Prognostic marker property qualitative detection Result reveal ROC AUC ROC Curve selected serum severity statistical significance subset supplementary material Treatment UHPLC UHPLC-MS/MS uninfected control Untargeted metabolomics validation study Viral Viral load viral nucleic acid was performed [DOI] 10.1007/s11306-021-01859-3 PMC 바로가기 [Article Type] Original Article
Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver CancerReview Published on 2021-12-082023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] immune mechanism intestinal flora Liver cancer metabolites occurrence and development Therapeutics [DOI] 10.3389/fcell.2021.702414 PMC 바로가기 [Article Type] Review