An uncommon variant of erythema nodosum leprosum responding well to methotrexate: Report of two casesarticle Published on 2021-10-312024-09-01 Journal: Trop Doct [Category] 한센병, [키워드] erythema nodosum leprosum leprosy methotrexate [Article Type] article
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery항바이러스 약물 발견을 위한 SARS-CoV-2-호스트 프로테옴 상호작용Article Published on 2021-10-282022-09-10 Journal: Molecular Systems Biology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] addition Affinity purification analyses Analysis antiviral activity antiviral drug Antiviral effect antiviral effects applied approach biological significance candidate drug caused cofactor cofactors complementary Compound COVID‐19 criterion Critical develop downstream drug Drug discovery effective therapy Host host cell host cell proteases host protein host proteins hub protein identify in viral inhibitory effect Interaction labeling list mass spectrometry methotrexate Microbiology, Virology & Host Pathogen Interaction molecular ORF Pharmacology & Drug Discovery protein targets protein–protein interactions proteome proteomics provided receptors Replication resource SARS‐CoV‐2 SARS‐CoV‐2 suggested understanding Viral viral pathogenesis viral replication Virtual screening virus–host interactions [DOI] 10.15252/msb.202110396 PMC 바로가기 [Article Type] Article
A review of the presentation and outcome of sarcoidosis in coronavirus disease 2019Review Article Published on 2021-10-262022-10-29 Journal: Journal of Clinical and Translational Research [Category] COVID-19, [키워드] acute respiratory syndrome added Admission article articles average Case report Case series case sery clinical manifestation Cohort Comorbidity conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Diagnosis drug General population Google High dose higher risk Hospital admission Hospitalization Hypothesis Immunocompromised patient immunomodulator Immunosuppressant increased risk intensive care management methotrexate mitigate moderate Mortality mortality rate multisystemic observation observational studies outcome overall mortality pandemic Patient patients Precaution presenting Prognosis Pulmonary function Relevance Research risk risk factor sarcoidosis significant difference Steroids Treatment Web of Science with COVID-19 PMC 바로가기 [Article Type] Review Article
Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19면역매개염증질환 및 코로나19 환자에서 종양괴사인자억제제와 입원 또는 사망 위험 간의 연관성Research Published on 2021-10-182022-09-12 Journal: JAMA Network Open [Category] MERS, SARS, 진단, [키워드] 6-mercaptopurine 95% CI accounted accounting Adult patients age Analysis Arthritis association azathioprine category Clinical characteristics cohort study Combination conducted correlations country COVID-19 COVID-19 diagnosis Crohn disease data entry death demographic and clinical characteristics diagnose Diagnosis died Europe excluded exposure Factor female finding higher odd higher odds Hospitalization Hospitalized immune pathway Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunomodulatory Importance individual Inflammatory arthritis Inflammatory bowel disease Inflammatory diseases inhibitor International Janus kinase Kinase inhibitor lower risk measure methotrexate monotherapy multivariable logistic regression Necrosis objective Odds ratio outcome pandemic participant Patient Point psoriasis receipt receiving reference treatment Relevance reported reporting bias Result Rheumatic diseases rheumatoid arthritis risk Sensitivity analyses sensitivity analysis setting significantly higher Support Symptom the mean therapy TNF treatment regimen Tumor tumor necrosis tumor necrosis factor [DOI] 10.1001/jamanetworkopen.2021.29639 PMC 바로가기 [Article Type] Research
Humoral Response to SARS-CoV-2 Vaccine of a Patient Receiving Methotrexate Treatment and Implications for the Need of MonitoringCase Report Published on 2021-10-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] AIIRD antibody antibody level assays Autoimmune disease Autoimmune diseases COVID-19 COVID-19 mortality diagnosed DiaSorin dose drug Elecsy female IgG immunomodulatory medications Immunomodulatory therapies indicate inhibitor LIAISON methotrexate monitoring MTX Necrosis Other Patient positive result receiving Research response rheumatoid arthritis risk Roche Diagnostics SARS-CoV-2 serum tested the antibody response TNFis treated Treatment vaccination Vaccinations Vaccine were measured [DOI] 10.3390/vaccines9101151 PMC 바로가기 [Article Type] Case Report
Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study자가면역 염증성 류마티스 질환 성인 환자 및 일반 인구에서 BNT162b2 mRNA COVID-19 백신의 면역원성과 안전성: 다기관 연구Observational Study Published on 2021-10-012022-09-12 Journal: Annals of the rheumatic diseases [Category] MERS, SARS, 임상, 진단, [키워드] adverse event Autoimmune binding antibody unit biological therapy BNT162b2 mRNA BNT162b2 mRNA vaccine Control control group COVID-19 COVID-19 pandemic COVID-19 vaccine death defined Disease activity Efficacy evaluated Factor General population Glucocorticoids herpes zoster IgG IgG antibody IgG level immunogenic immunogenicity Inflammatory Major majority Messenger RNA methotrexate Mild MMF mRNA multicentre Older age Patient patients postvaccination Protein reduced remained rheumatic disease rituximab S1/S2 safety profile SARS-CoV-2 spike seronegative Seropositivity significantly significantly lower symptomatic case Treatment two-dose regimen vaccination Vaccine vaccine dose were assessed were measured [DOI] 10.1136/annrheumdis-2021-220647 PMC 바로가기 [Article Type] Observational Study
TNFi is associated with positive outcome, but JAKi and rituximab are associated with negative outcome of SARS-CoV-2 infection in patients with RMDTNFi는 긍정적인 결과와 관련이 있지만 JAKi와 rituximab은 RMD 환자에서 SARS-CoV-2 감염의 부정적인 결과와 관련이 있습니다.Article Published on 2021-10-012022-09-12 Journal: RMD Open [Category] 진단, [키워드] 95% CI analysed antirheumatic agents association cardiovascular disease Chronic kidney disease chronic lung disease collected Course COVID-19 COVID-19 severity Cyclophosphamide disease Disease activity feature glucocorticoid Glucocorticoids hospitalised hypertension Immunosuppressant Inflammatory influence inhibitor Janus kinase Male sex methotrexate MTX multivariable Musculoskeletal ordinal logistic regression outcome Patient patients died positive psoriatic arthritis rheumatoid arthritis risk factor SARS-COV-2 infection severe COVID-19 severity of COVID-19 TNF Treatment Ventilated [DOI] 10.1136/rmdopen-2021-001896 PMC 바로가기 [Article Type] Article
COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responsesReview article Published on 2021-10-012022-10-05 Journal: The Lancet Rheumatology [Category] 치료법, [키워드] collected COVID-19 COVID-19 pandemic cytokine inhibitors Diagnosis disease Diseases glucocorticoid high risk immune response Immune-mediated Immune-mediated inflammatory disease Immune-mediated inflammatory diseases Inflammatory Inflammatory arthritis Inflammatory bowel disease medication methotrexate outcome outcomes Patient reduced risk SARS-COV-2 infection SARS-CoV-2 vaccination severe COVID-19 Tolerability Treatment vaccination vaccine response [DOI] 10.1016/S2665-9913(21)00247-2 [Article Type] Review article
Management of tubal ectopic pregnancy with methotrexate in the setting of symptomatic Coronavirus disease 2019 (COVID-19): A case reportCase Report Published on 2021-09-242022-10-31 Journal: Facts, Views & Vision in ObGyn [Category] COVID-19, [키워드] Case report Comorbidity complex coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection ectopic Ectopic pregnancy knowledge literature review management methotrexate objective pandemic progresses Patient precluded Pregnancy presenting receiving Result severe COVID-19 supportive care symptomatic the patient therapeutic therapeutic option [DOI] 10.52054/FVVO.13.3.030 PMC 바로가기 [Article Type] Case Report
Efficacy and safety of tofacitinib by background methotrexate dose in psoriatic arthritis: post hoc exploratory analysis from two phase III trialsOriginal Article Published on 2021-09-122024-09-02 Journal: Clinical Rheumatology [Category] 대상포진, [키워드] Disease activity Disease-modifying anti-rheumatic drugs methotrexate psoriatic arthritis Tofacitinib [DOI] 10.1007/s10067-021-05894-2 PMC 바로가기 [Article Type] Original Article