Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19중화 항체의 급격한 감소는 가벼운 COVID-19에서 회복된 성인의 IgM 붕괴와 관련이 있습니다Article Published on 2021-04-202022-09-11 Journal: Cell Reports Medicine [Category] MERS, SARS, 진단, 치료법, [키워드] age anti-RBD anti-receptor-binding domain anti-S antibody Antibody avidity Antibody Response Antibody responses avidity binding Cohort COVID-19 Decline declines defined Fever Follow-up functional Gender IgA IgG IgM Immunoglobulin immunoglobulin A implication increase Infection levels of antibodies Mild mild infection mild SARS-CoV-2 infection Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses observation observé participant protective immunity Protein Rapid RBD respiratory responses SARS-CoV-2 SARS-COV-2 infection symptom onset trimer Viral Viral antigen viral antigens [DOI] 10.1016/j.xcrm.2021.100253 PMC 바로가기 [Article Type] Article
Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects회복된 COVID-19 피험자에서 항 SARS-CoV-2 항체의 특성Article Published on 2021-04-162022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD Anti-RBD IgG anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 immunoglobulin antibody Antibody Response caused Chain Reaction characterized coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection cycle threshold determine determined by diagnose domain elicit ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay global pandemic highlight humoral immune response Immunity Immunoglobulin individual Infection mild infection neutralize live SARS-CoV-2 polymerase chain polymerase chain reaction post-symptom onset Protein raise RBD RBD IgG titers Receptor-binding domain recovered resolved respiratory reverse transcription RT-PCR SARS-CoV-2 SARS-CoV-2 virus Serological assay serological assays serological survey Serological surveys serology subject subjects symptom onset Viral viral neutralization virus while [DOI] 10.3390/v13040697 PMC 바로가기 [Article Type] Article
Clinical Features of Patients with Home Isolation Sars-Cov-2 Infection: A Multicenter Retrospective Study in Southern ItalyArticle Published on 2021-04-162022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] age Asymptomatic Care chronic disease clinical clinical feature Clinical practice Comorbidity COVID-19 defined disease enrolled epidemiological evaluated Factor home Home isolation home management hospital hospital management Hospitalized hospitalized patient independent IQR Isolation Italy less Logistic regression analysis male management median median age mild clinical presentation mild infection multicenter nine oxygen Patient patients with SARS-CoV-2 performed receiving required Retrospective study SARS-COV-2 infection Severe infection subject therapy unit [DOI] 10.3390/life11040347 PMC 바로가기 [Article Type] Article
Asymptomatic Cases, the Hidden Challenge in Predicting COVID-19 Caseload IncreasesArticle Published on 2021-04-092022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] approach Asymptomatic caseloads challenge children Clusters cough COVID-19 COVID-19 case dataset effort estimate Fever growth highlight increase index case indicate indicated lowest maintain Mask mild infection Novel coronavirus Pearson correlation coefficient pre-symptomatic Research shown spread of COVID-19 Symptom symptomatic transmission-risk virus [DOI] 10.3390/idr13020033 PMC 바로가기 [Article Type] Article
Thromboinflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 PatientsResearch article Published on 2021-04-012022-10-05 Journal: Mayo Clinic Proceedings: Innovations, Quality & Outcomes [Category] 바이오마커, 유전자 메커니즘, [키워드] 95% CI Biomarker biomarkers of inflammation C-reactive protein C-reactive protein (CRP Cerebrovascular disease Chronic kidney disease chronic obstructive CINAHL Controlled Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 severity COVID-19coronavirus disease 2019 criteria CRP CRPC-reactive protein D-dimer database death diabetes disease disease severity ECMOextracorporeal membrane oxygenation end-organ damage evaluate extracorporeal membrane oxygenation ferritin fibrinogen greater group heterogeneity high-sensitivity hospitalized patient hshigh-sensitivity hypertension IL-6interleukin 6 inferences interleukin 6 lactate dehydrogenase LDHlactate dehydrogenase malignancy marker mean difference men mild infection Mortality objective Odds ratio Older OROdds Ratio parameter Patient patients Prevalence proportion pulmonary disease random-effects model Result review searched severe coronavirus disease severe COVID-19 disease severe disease severity significantly higher survivor thrombosis troponin I was used Web of Science weighted mean difference WMDweighted mean difference [DOI] 10.1016/j.mayocpiqo.2021.01.009 [Article Type] Research article
Clearing the Fog: Is Hydroxychloroquine Effective in Reducing Coronavirus Disease-2019 Progression? A Randomized Controlled TrialInternal Medicine Published on 2021-03-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] A p-value addition age analyzed assigned Clearing conducted control group Controlled Controlled trial coronavirus disease coronavirus disease-2019 COVID-19 Disease progression Efficacy Emirate enrolled HCQ help Hospitalized IBM Intervention intervention group Mild mild COVID-19 patient mild infection negativity Patient patients PCR PCR negativity polymerase chain progressed RCT reducing Result Science secondary outcome Standard dose Standard of care Statistical Package sustained Treatment viral clearance [DOI] 10.7759/cureus.14186 PMC 바로가기 [Article Type] Internal Medicine
SARS-CoV-2 viral dynamics in non-human primates인간이 아닌 영장류의 SARS-CoV-2 바이러스 역학Research Article Published on 2021-03-172022-09-10 Journal: PLoS Computational Biology [Category] SARS, 치료제, [키워드] absence antiviral treatments association Asymptomatic basic number basic reproduction number burst size clearance Clinical signs cynomolgus macaque cynomolgus macaques cytokine declined develop Efficacy estimate estimates half-life human infection human infections immune markers infected cell infected cells infected with SARS-CoV-2 kinetic mathematical mathematical model median time Mild mild infection nasopharyngeal nasopharynx Non-human non-human primate non-human primates observation observations parameter predict Prevent prophylactic therapy prophylactic treatment reproductive SARS-CoV-2 viral Trachea tracheal Viral viral clearance viral dynamics viral entry viral growth viral infection Viral load viral loads virus [DOI] 10.1371/journal.pcbi.1008785 PMC 바로가기 [Article Type] Research Article
Point-of-care SARS-CoV-2 serological assays for enhanced case finding in a UK inpatient population영국 입원 환자 집단에서 향상된 사례 발견을 위한 현장 진료 SARS-CoV-2 혈청학적 분석Article Published on 2021-03-122022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] acute phase acute respiratory syndrome coronavirus Antibody test antibody test kits applicability applied case finding cassette Chain Reaction clinical microbiology complications Concordance coronavirus COVID-19 early infection evaluated false-negative FIVE General population global pandemic healthcare help IMPROVE independent Infectious-disease diagnostics inferiority mild infection negative not seen Patient patient cohorts PCR PCR testing POC point-of-care polymerase chain polymerase chain reaction populations Positive predictive value PPV Predictive value Rapid Rapid test real-time polymerase chain reaction required respiratory SARS-CoV-2 SARS-CoV-2 antibody test sensitivity Serological assay serological assays serological test Serological tests serology testing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread symptom onset Test tested utility Virology [DOI] 10.1038/s41598-021-85247-w PMC 바로가기 [Article Type] Article
Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection경도 SARS-CoV-2 감염에 대한 항체 반응의 이질성 및 혈청 역전의 시계열 분석 및 기계론적 모델링Research Paper Published on 2021-03-022022-09-11 Journal: EBioMedicine [Category] SARS, 진단, 치료법, [키워드] Analysis Anti-S1 antibody antibody levels antibody production Antibody Response antibody titres assays Asymptomatic Blood blood sampling changes in clearance Comparisons correlated deaths evaluate Extended faster finding Follow-up funding greater healthcare worker heterogeneity heterogeneous Humoral immunity identify IgG Infection infections London Longevity Longitudinal studies longitudinal study Mathematical modelling mechanism median Mild mild infection mild SARS-CoV-2 infection neutralising antibody titre NIHR participant PCR peak population level positive production rate prospective cohort study protective humoral immunity pseudovirus pseudovirus neutralizing antibody recruited reduction in reductions in required response Roche S1 domain SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection SARS-CoV-2, Serology, Mathematical modelling, Sero-reversion semi-quantitative serological analysis serological response serology sustained Symptom time transition Viral viral nucleocapsid protein viral spike was performed Wellcome Trust [DOI] 10.1016/j.ebiom.2021.103259 PMC 바로가기 [Article Type] Research Paper
Effect of age, comorbidity and remission status on outcome of COVID-19 in patients with hematological malignanciesObservational Study Published on 2021-03-012022-10-05 Journal: Blood cells, molecules & diseases [Category] 임상, [키워드] 28-day mortality age anticancer antivirals Chemotherapy Cohort cohorts Comorbidity conducted contributed cough COVID-19 COVID-19 in patient COVID-19 infection death rate disease Effect elderly enrolled Hematological malignancies Hematological malignancy hematology India Infection lymphoid malignancy mild infection moderate MOST multicentre negativity one patient outcome oxygen Patient Remission RT-PCR Secondary objective Seven Severe COVID-19 Infection severe disease Severe infection significantly study period survival Total Treatment [DOI] 10.1016/j.bcmd.2020.102525 PMC 바로가기 [Article Type] Observational Study