Serum microRNAs targeting ACE2 and RAB14 genes distinguish asymptomatic from critical COVID-19 patientsResearch article Published on 2022-06-112022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 바이오마커, 변종, 진단, [키워드] ACE2 analyzed approach Asymptomatic asymptomatic individual Asymptomatic individuals Biomarkers candidate change Control controls COVID-19 COVID-19 disease COVID-19 progression Critical critical COVID-19 patient determine disease disease severity expression Factor future therapeutic Host identify in silico analysis in viral individual Inflammatory response mechanism microRNA miRNA MT: Non-coding RNAs pathology Patient performed Potential biomarker promote Protein question RAB14 Replication respond SARS-CoV-2 serum target gene TMPRSS2 upregulated viral entry viral infection were measured [DOI] 10.1016/j.omtn.2022.06.006 [Article Type] Research article
Identification of a Novel HBV Encoded miRNA Using Next Generation SequencingArticle Published on 2022-06-052023-06-13 Journal: Viruses [Category] B형 간염, [키워드] Chronic Hepatitis B Hepatitis B virus liver tissue miRNA next generation sequencing [DOI] 10.3390/v14061223 PMC 바로가기
A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs숙주 miRNA를 사용하여 orf8 유전자의 보존된 대체 예비를 억제함으로써 SARS-CoV-2 복제를 표적으로 하는 생물정보학적 접근Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] adopted approach binding affinity causative agent compensating conserved COVID-19 COVID-19 pandemic deleting docked exhibit functional gene sequence gene silencing Genes homology Host host immunity host miRNA Hypothesis indels Interaction miRNA miRNAs modulate molecular docking mRNA multiple mutation multiple mutations mutations omicron Omicron variant ORF7a ORF7a gene ORF8 ORF8 gene partial sequence responsible Result SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus screened sequence similarity the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach variant variants viral genome viral replication viral strain virus while wild type without affecting Wuhan [DOI] 10.1016/j.compbiomed.2022.105436 PMC 바로가기 [Article Type] Article
Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients간세포암 환자에서 SARS-CoV-2 감염에 대한 표적 및 약물 예측Article Published on 2022-05-312022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Cell clinician Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical dataset datasets differentially expressed differentially expressed gene drug drugs effective effective drug effective drugs epithelial cell functional genomes HCC HCC patient HCC patients Hepatocellular carcinoma hub genes Human identify Ilomastat infected with SARS-CoV-2 Interaction Kyoto lung epithelial microRNA MicroRNAs miRNA molecular Ontology pandemic pathway Patient patients Protein protein-protein interaction provide Research reveal SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 synergistic synergistic effect target terminology therapeutic transcription factor transcriptomic analysis Treatment was performed with COVID-19 [DOI] 10.1371/journal.pone.0269249 PMC 바로가기 [Article Type] Article
Plasma Torquetenovirus (TTV) microRNAs and severity of COVID-19혈장 토르케테노바이러스(TTV) microRNA와 COVID-19의 심각성Article Published on 2022-05-132022-09-11 Journal: Virology Journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Anelloviridae association biological fluids coding sequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity detection disease DNA followed by immune immune evasion in viral incidence rate Inflammatory response investigated involved microRNA MicroRNA expression miRNA miRNAs MONITOR outcome outcomes PCR assay plasma plasma sample plasma samples Prevalence Quantitative rate ratio RT-PCR SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus severity severity of COVID-19 significantly Spectrum stages subject subjects susceptible TaqMan tested the healthy the patient torquetenovirus Variation variations Viral immune evasion Viremia were assessed widespread [DOI] 10.1186/s12985-022-01812-3 PMC 바로가기 [Article Type] Article
Identification of Diagnostic Gene Markers and Immune Infiltration in Systemic Lupus전신성 루푸스에서 진단 유전자 마커 및 면역 침윤의 식별Article Published on 2022-05-102022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 바이오마커, 치료기술, [키워드] Activation advancement Analysis analyzed Atypical autoantibodies autoantibody Autoantigens Autoimmune disease B cells bioinformatics Biomarker Central nervous system characteristic clinical manifestation clinical manifestations Clinical practice coexpressed coexpression network complexes control group coronavirus coronavirus disease correlation COVID-19 current DEGs determine Diagnosis diagnostic differentially expressed gene Differentially expressed genes disease downloaded downregulated Endocrine endocrine system enrichment analysis etiology evaluate expression data Factors fraction functional gene expression profile Genes Genetic GEO database healthy control healthy controls help heterogeneous highest hub genes human body identification identify Immune cell immune cells Immune complexes immune function Infection Interaction joints KEGG kidney leukemia Lupus lupus erythematosus miRNA multiple organs Participation Pathogenesis pathway Pathways Patient patients performed Population Potential biomarker potential biomarkers PPI PPI network protein-protein interaction receiver operating characteristic recognize regulatory network Research resulting ribosome ROC ROC Curve RPL19 RPS17 RPS19 RPS7 selected skin SLE SLE patient SLE patients Symptom systemic systemic lupus erythematosus T cell T cells the disease the healthy transcription factor Treatment turquoise module upregulated variety virus was selected was used weighted gene coexpression network analysis WGCNA whole blood sample [DOI] 10.1155/2022/3386999 PMC 바로가기 [Article Type] Article
Circulating microRNA profiling is altered in the acute respiratory distress syndrome related to SARS-CoV-2 infection Research Published on 2022-04-282022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute inflammatory response acute respiratory distress analyzed ARDS cellular COVID-19 COVID-19 patients Cytokine storm Cytokine storm syndrome dataset differentially expressed miRNA enriched pathway fat cell fold Gene Expression hallmark immune immune dysregulation in silico analysis independent Infection Inflammatory response Inflammatory responses intensive care involved mechanical ventilation microRNA miRNA miRNAs parameter pathway enrichment Patient patient groups physiological Prognosis qPCR receptor protein Regulation resulting SARS-COV-2 infection Sequencing significantly Symptom syndrome transmembrane was performed with COVID-19 [DOI] 10.1038/s41598-022-10738-3 [Article Type] Research
Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 PatientsCOVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화Article Published on 2022-04-152022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] 유전자 메커니즘, [키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased [DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article
Nanodelivery of nucleic acids Reviews Published on 2022-04-142022-10-05 Journal: The Pan African Medical Journal [Category] 유전자 메커니즘, [키워드] biological system Cell diagnostics DNA Efficacy gene silencing Gene therapy microRNA miRNA modulate molecular mRNA Nanomaterial nucleic acid offer overcome physico-chemical properties Protein RNA RNA expression Safe selective siRNA therapeutic tissues Vaccines [DOI] 10.1038/s43586-022-00104-y [Article Type] Reviews
Detection of SARS-CoV-2 infection by microRNA profiling of the upper respiratory tract상기도의 microRNA 프로파일링에 의한 SARS-CoV-2 감염 검출Article Published on 2022-04-052022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Accuracy Biomarker circulating collected COVID-19 COVID-19 case COVID-19 cases COVID-19 patients detection develop expression host miRNA response host-encoded microRNA identify IL-6 increasingly interleukin interleukin-6 invasive machine learning analysis microRNA mir-93 miRNA miRNA signature miRNAs nasal tissue Prognosis SARS-COV-2 infection signature specimen Supervised machine learning analysis upper respiratory tract upregulated [DOI] 10.1371/journal.pone.0265670 PMC 바로가기 [Article Type] Article