Artificial Intelligence Predicts Severity of COVID-19 Based on Correlation of Exaggerated Monocyte Activation, Excessive Organ Damage and Hyperinflammatory Syndrome: A Prospective Clinical Study인공 지능, 과장된 단핵구 활성화, 과도한 장기 손상 및 과염증 증후군의 상관 관계를 기반으로 COVID-19의 심각도 예측: 전향적 임상 연구Immunology Published on 2021-08-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] Accuracy Admission Alanine alanine aminotransferase Algorithms ALT Analysis analyzed applied artificial artificial intelligence aspartate Aspartate aminotransferase AST biochemical analyses Biomarker C-reactive protein C-reactive protein (CRP chemokine chemokines clinical COVID-19 COVID-19 patient COVID-19 patients creatinine CT scan CT scans cytokine Cytokines D-dimer damage develop eight fibrinogen forest gamma interferon Glucose healthy control HMGB1 hospitalized COVID-19 patient identify IL-6 intelligence interferon Laboratory Lactate lactate dehydrogenase LDH Logistic regression Lungs Macrophage macrophage derived cytokine management mDC methodology MIG moderate moderate disease monocyte monokine objective on admission parameter predict prediction prediction models predictor Prognostic factor Prognostic factors Prognostic value Prospective provide Random forest reduce mortality Result severe disease severely ill patient severely ill patients severity severity of COVID-19 significantly higher support vector machine the disease the patient [DOI] 10.3389/fimmu.2021.715072 PMC 바로가기 [Article Type] Immunology
Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patientsSARS-COV-2 항-스파이크 단백질 RBD IgG의 비교 동역학 및 BNT162B2 mRNA 백신 대 COVID-19 환자의 회복기 및 순진한 수용자에서 중화 항체의 비교 동역학Comparative Study Published on 2021-08-232022-09-01 Journal: BMC Medicine [Category] MERS, SARS, 진단, [키워드] Abstract Anti-S-RBD IgGs Anti-spike Antibody titer Antibody titers Antigen BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine causative agent caused Cellular immune response clone Cohort Comparative contribute convalescent coronavirus COVID-19 COVID-19 patient COVID-19 recovered patient COVID-19 recovered patients dose global pandemic healthy Hospitalized hospitalized patient hospitalized patients humoral Humoral and cellular immune responses IgG IgGs immune immune response immune responses Immunity induce investigated moderate moderate disease moderate or severe disease mononuclear cells NAb NAbs naïve natural infection Neutralizing antibodies neutralizing antibody offer participant Peripheral blood Peripheral blood mononuclear cells priming priming vaccination promote Protein RBD IgG RBD IgGs recipient recipients response Result robust SARS-CoV-2 serum severe COVID-19 severe disease significantly higher supplementary material Support T cell titers Trigger triggers vaccinated individual vaccinated individuals vaccination vaccination efficacy Vaccine viral infection virus infection were measured [DOI] 10.1186/s12916-021-02090-6 PMC 바로가기 [Article Type] Comparative Study
Delayed neutralizing antibody response in the acute phase correlates with severe progression of COVID-19급성기에서 지연된 중화 항체 반응은 COVID-19의 심각한 진행과 관련이 있습니다.Article Published on 2021-08-162022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immunity Admission analyzed antibodies chemiluminescence collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critical disease Delayed different time points disease disease severity Hospitalization moderate moderate disease NAb nAb response NAbs neutralization neutralization activity neutralization test Neutralizing activity neutralizing antibody Neutralizing antibody response on admission pathology Patient patients patients with moderate progression Pseudotyped virus reduction respiratory SARS-CoV-2 SARS-CoV-2 pseudotyped virus serum serum sample severe acute respiratory syndrome Coronavirus significantly higher symptom onset symptomatic viral infection were measured [DOI] 10.1038/s41598-021-96143-8 PMC 바로가기 [Article Type] Article
HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanismResearch Article Published on 2021-08-122022-10-29 Journal: The Journal of Headache and Pain [Category] COVID-19, MERS, SARS, [키워드] ACE2 age Angiotensin II CGRP Characteristics circulating clinical comparable correlated COVID-19 COVID-19 patient COVID-19 patients cross-sectional D- dimer diarrhea elevated enrolled Frequency groups headache HMGB1 Hospital stay Hospitalized hospitalized COVID-19 patient IL-10 IL-6 Increased Inflammation Inflammatory Inflammatory response Laboratory test mechanism moderate disease nausea Neuron NLRP3 pandemic Paracetamol Patient pulmonary involvement Result SARS-COV-2 infection second wave Serum level severity significantly significantly higher suffered weight loss were recorded [DOI] 10.1186/s10194-021-01306-7 PMC 바로가기 [Article Type] Research Article
Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up급성 COVID-19에서 성상세포 및 신경세포 손상의 신경화학적 징후는 장기 추적 관찰 중에 정상화됩니다Research Paper Published on 2021-07-292022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 바이오마커, 진단, [키워드] accompanied Acidic acute COVID-19 acute phase analysed association Biomarker Biomarkers blood sample Blood samples changes in Clinical research CNS Cognition collected Concentration Control controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 determine disease severity fatigue feature finding Follow-up foundation funding GDF-15 GFAp group growth indicate individual individuals Injury IQR Knut Long-term follow-up manifestation median Mild moderate moderate disease Neurochemical neurologic neurological Neurological symptom Neurological symptoms neuronal NfL no correlation normalization normalized Patient plasma biomarker plasma concentration plasma concentrations Protein provided reported SARS-CoV-2 severe COVID-19 significantly increased state Swedish the disease were recorded [DOI] 10.1016/j.ebiom.2021.103512 PMC 바로가기 [Article Type] Research Paper
Acute Lung Injury Biomarkers in the Prediction of COVID-19 Severity: Total Thiol, Ferritin and Lactate DehydrogenaseArticle Published on 2021-07-292022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome Alpha analysed appear ARDS Biomarkers blood sample C-reactive protein can be used Clinical management COVID-19 COVID-19 patients CRP D-dimer death dehydrogenase develop elevated enrolled ferritin glycosylated Hospital admission Hospital stay IL-6 immunoassay IMPROVE lactate dehydrogenase LDH lymphocyte marker Mild moderate disease Necrosis Non-survivors parameter Patient patients patients with ARDS prediction Prognosis prognostic biomarker prospective cohort study SARS-CoV-2 serum biomarker severe disease significantly significantly higher significantly lower Stress subject Support syndrome TGF-β thiol TNF-α Total total thiol [DOI] 10.3390/antiox10081221 PMC 바로가기 [Article Type] Article
The Relation of ABO Blood Group to the Severity of Coronavirus Disease: A Cross-Sectional Study From a Tertiary Care Hospital in KarachiInfectious Disease Published on 2021-07-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ABO ABO blood group association Blood Group Chinese collected Comorbidities coronavirus disease COVID-19 COVID-19 patient demographics determine diabetes Diabetes Mellitus diabetic patient diabetics disease severity distribution female Final Gender group hemoglobin highest hypertension individual Karachi Laboratory parameters less male male gender material methodology Mild moderate disease Mortality multiple logistic regression objective Occurrence P-value Patient patients questionnaire relation Result severe disease severity South Asian Study participants Tertiary Univariate analysis was used while [DOI] 10.7759/cureus.16598 PMC 바로가기 [Article Type] Infectious Disease
COVID-19 in Children: Expressions of Type I/II/III Interferons, TRIM28, SETDB1, and Endogenous Retroviruses in Mild and Severe CasesArticle Published on 2021-07-132022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Activation Adults Amplification assay children comparable Concentration contribute controls correlation COVID-19 COVID-19 patient COVID-19 patients cross-talk Decline deficiency disease endogenous Evolution Exogenous expression expression level Genes HERV HERVs human endogenous retrovirus human endogenous retroviruses IFN IFN-I IFN-III IFN-λ IFNs immune reactions immune response induce Infection Inflammatory information interferon involved Mild mild symptoms MIS-C moderate disease New coronavirus patients PCR Pediatric patients Peripheral blood positive correlation preserved Prognosis real time regulate reported retrovirus SARS-CoV-2 SARS-COV-2 infection SETDB1 Severe case severe disease stimulated subjects Symptom SYN2 syndrome Transcription transcriptional level TRIM28 turn Type type I uninfected upregulation viral infection [DOI] 10.3390/ijms22147481 PMC 바로가기 [Article Type] Article
Single-cell analysis reveals cell communication triggered by macrophages associated with the reduction and exhaustion of CD8 + T cells in COVID-19단일 세포 분석은 COVID-19에서 CD8 + T 세포의 감소 및 고갈과 관련된 대식세포에 의해 촉발된 세포 통신을 보여줍니다Observational Study Published on 2021-07-082022-09-12 Journal: Cell Communication and Signaling : CCS [Category] 임상, 진단, [키워드] activity acute respiratory syndrome Algorithm Analysis analyzed AST AUROC Bronchoalveolar lavage fluid calculate caused CD4 CD8 Cell cell types cellular clinical collected composed condition contributed coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis COVID-19 patients CXCL10 cytokine D-dimer demonstrated described driving Efficacy enrolled Flow cytometry analysis functional heterogeneity hospitalized patient hypoxia IGF1 IL10 IL1β IL6 Immune cell IMPROVE independent risk factor Infection Inflammatory information Interaction interactions Laboratory tests Logistic regression analysis Macrophage Measures microenvironment moderate disease molecular mechanism multivariate offer outbreak outcome pandemic parameters pathway Patient Predictive ranged reduction respiratory immune Result retrospective reveal risk SARS-CoV-2 scRNA-seq data selective serum cytokine severe disease severity of COVID-19 significantly lower Single cell RNA-sequencing single-cell single-cell analysis subtype supplementary material T cell T cell subset T cells target therapy TNFα Trial registration triggered understanding Vaccines was used WBC Weighting were measured [DOI] 10.1186/s12964-021-00754-7 PMC 바로가기 [Article Type] Observational Study
Clinical features and predictors for patients with severe SARS-CoV-2 pneumonia at the start of the pandemic: a retrospective multicenter cohort studyResearch Article Published on 2021-07-082022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] 95%CI Analysis carried China Chinese clinical clinical feature Clinical outcome clinical recovery collected Corticosteroids demographic dose feature Final Hospital stay identify independent risk factor indicated Laboratory likelihood Logistic regression Lymphocyte count lymphocyte counts Mild moderate moderate disease multicenter cohort study multivariate non-severe cases Odds ratio pandemic Patient Peripheral blood Pneumonia predictor Prospective Study reduced Registered registry Result retrospective risk factor Risk factors SARS-CoV-2 SARS-CoV-2 pneumonia Severe case severe cases Severe patient severe patients severe SARS-CoV-2 significantly small sample size Symptoms systematic corticosteroid viral shedding was performed [DOI] 10.1186/s12879-021-06335-w PMC 바로가기 [Article Type] Research Article