In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening [DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article
Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection바이러스 부하는 급성 중증 SARS-CoV-2 감염에서 미토콘드리아 기능 장애 및 변경된 단핵구 표현형과 관련이 있습니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD16 CD39 Cell cell surface classical monocyte classical monocytes Clinical outcome COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity determined by evaluated exhibited expression Frequency GM-CSF healthy control healthy controls high viral load HLA-DR Hospital admission IFN-α Immune checkpoints induce Infection initial innate immune innate immune response less membrane Mitochondria mitochondrial mitochondrial dysfunction Mitochondrial function monocyte Monocyte activation Monocytes oxygen pathological mechanism patients PD-1 phenotype reactive oxygen species reactive oxygen specy SARS-CoV-2 SARS-CoV-2 viral load severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe SARS-CoV-2 severity the cell the median These data Viral viral burden Viral load with COVID-19 [DOI] 10.1016/j.intimp.2022.108697 PMC 바로가기 [Article Type] Article
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness케모카인, 가용성 PD-L1 및 면역 세포 저반응은 SARS-CoV-2 중병의 뚜렷한 특징입니다Article Published on 2022-07-012022-09-12 Journal: American journal of physiology. Lung cellular and [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ARDS C-reactive protein CCL17 CCL26 cellular checkpoint pathway chemoattractant comparison coronavirus disease Coronavirus-2 COVID-19 Critical Critically ill patient CRP CXCL10 demographics enrolled feature hyporesponsiveness identify IFN-γ IL-10 IL-17A IL-6 IL-8 immune Immune cell immune signature in vitro Interaction less lymphocyte Migration molecular monocyte mortality rate multisite not significantly different p value Patient patients patients without COVID-19 PD-L1 plasma Pneumonia profile prospective cohort Regulatory SARS-CoV-2 SARS-CoV-2-positive patient SARS-CoV-2-positive patients Sepsis severe respiratory failure severity subject subjects T cell T-cell TNF-α two groups ventilator-free day with COVID-19 [DOI] 10.1152/ajplung.00049.2022 PMC 바로가기 [Article Type] Article
Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications단핵구 anisocytosis는 심혈관 합병증이있는 어린이의 다기관 염증 증후군 동안 증가합니다Article Published on 2022-06-202022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI Accuracy Analysis anisocytosis blood count blood sample Blood samples Cardiac complications cardiovascular complication Care CBC Child children children with MIS-C clinically Cohort collected complete blood count complex COVID-19 creating develop diagnostic Diagnostic accuracy disease distribution effective enrolled greater healthy controls hematologic identify illnesses IMPROVE increase Inflammatory initial Laboratory Laboratory test life-threatening Medical care MIS-C monocyte Monocyte distribution width multisystem inflammatory syndrome in children New on children outcome parameters pediatric COVID-19 quantified required risk SARS-COV-2 infection sensitivity single medical center specificity subject syndrome tested threshold time-consuming Treatment utility validation cohort [DOI] 10.1186/s12879-022-07526-9 PMC 바로가기 [Article Type] Article
Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia중증 COVID-19 폐렴 노인 환자의 분자 및 세포 면역 특징Article Published on 2022-06-162022-09-12 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] activated activated macrophage age aging anti-RBD anti-S anti-viral response antibodies CD4 CD56 Cell cellular central memory circulating Clinical outcome collagen concerning Cytokines difference disease severity elderly exacerbate feature fibrosis follicular helper T cell IgG3 immature immune immune characteristics immunological change individuals Infection Inflammation less lung macrophages monocyte mononuclear cells Patient patients percentage Peripheral blood plasma plasmablasts pro-inflammatory cytokines pro-inflammatory monocytes promote proportion reduced reported risk factor SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia severe SARS-CoV-2 specific antibody subject T cell T cells Transcriptome transcriptomic profile [DOI] 10.1038/s42003-022-03537-z PMC 바로가기 [Article Type] Article
Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 InfectionSARS-CoV-2 감염의 자가 보고된 신경학적 후급성 후유증이 있는 사람들의 신경학적 손상 및 염증의 혈장 표지자Article Published on 2022-06-142022-09-11 Journal: Neurology® neuroimmunology & neuroinflammation [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% CI absolute levels Acidic acute infection acute respiratory syndrome acute respiratory syndrome coronavirus biologic CNS Cohort coronavirus correlated correlation correlations defined demonstrated early recovery elevated Elevation elevations examined exhibited Fold change Fold changes GFAp greater identify immune activation immunologic marker individuals Infection Inflammation inflammatory pathway initial Injury interleukin interleukin 6 Intervention involved less light chain linear marker mechanism mixed-effects model monocyte monocyte chemoattractant protein 1 Necrosis neurologic not differ PASC Prevent primary clinical outcome Protein Recovery time reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Symptom Symptoms treat Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α [DOI] 10.1212/NXI.0000000000200003 PMC 바로가기 [Article Type] Article
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR Research Published on 2022-06-132022-10-05 Journal: Nature biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] Activation Antigen-specific T cells antigens breakthrough infections Cell cellular immunity chemokine correlated CXCL10 expression functional helping IFN-γ Immunity magnitude Messenger RNA monocyte mRNA normalized PCR populations protective immune response quantification quantitative PCR Rapid revaccination risk RNA extraction SARS-CoV-2 SARS-CoV-2 viral secrete stimulate T cell T cell activation [DOI] 10.1038/s41587-022-01347-6 [Article Type] Research
Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients입원 시 해당과정 부산물인 메틸글리옥살의 혈장 수준 상승은 ICU COVID-19 환자의 사망률에 대한 독립적인 바이오마커입니다Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] MERS, 바이오마커, 치료기술, 치료법, [키워드] Admission Biomarker Biomarkers byproduct Care correlated COVID-19 patient COVID-19 patients CRP death died elevated enzyme Evidence evidence of explained glutathione Glycolysis high risk ICU ICU patient ICU Patients identify IL-1β independent inflammation markers Logistic regression analysis management methylglyoxal monocyte Monocytes Mortality on admission Patient plasma Plasma levels predict provide regression analysis survived therapeutic These data TNF-α uninfected control Variability [DOI] 10.1038/s41598-022-12751-y PMC 바로가기 [Article Type] Article
Chlorpromazine, a Clinically Approved Drug, Inhibits SARS-CoV-2 Nucleocapsid-Mediated Induction of IL-6 in Human Monocytes임상적으로 승인된 약물인 클로르프로마진, 인간 단핵구에서 SARS-CoV-2 뉴클레오캡시드 매개 IL-6 유도 억제Article Published on 2022-06-072022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료법, [키워드] activated Acute respiratory failure Affect Antiviral caused chlorpromazine Course COVID-19 COVID-19 pandemic COVID-19 symptom COVID-19 symptoms creating cytokine Cytokine storm Cytokines drug expression human monocyte hyperinflammatory state IL-6 immunomodulatory activity in some induction inhibit interleukin interleukin 6 macrophages monocyte Monocytes neuroleptic NF-κB nucleocapsid protein overcome patients with COVID-19 Pneumonia proinflammatory Respiratory failure resulting Safe SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus nucleocapsid protein secreted secretion Severe infection severe infections Signaling Support target the disease therapy Vaccine [DOI] 10.3390/molecules27123651 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular CytotoxicitySARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다Article Published on 2022-06-072022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accessory accessory protein accessory proteins ADCC addition antibody-dependent cellular cytotoxicity bind CD16 CD8+ T cell coronavirus decrease disease evade Fc-mediated effector function help host immune responses humoral responses identify immune evasion monocyte Monocytes mononuclear cell mutate nanomolar affinity Neutralizing antibodies NK cells ORF8 PBMC Peripheral blood Protein reduce reducing SARS-CoV-2 SARS-CoV-2-infected cell significantly spike susceptibility [DOI] 10.3390/v14061237 PMC 바로가기 [Article Type] Article