Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform다용도 아데노바이러스에서 영감을 받은 다중화 플랫폼으로 면역화를 통한 강력한 SARS-CoV-2 중화 항체 반응 유도Article Published on 2022-05-042022-09-12 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adenovirus Antigen Antigen display antigenic approach boost COVID-19 COVID-19 convalescent patients COVID-19 vaccine Cryoelectron microscopy demonstrated dodecahedron domain glycosylated humoral immune response immunization mouse neutralization titers Neutralizing antibodies non-infectious Particle Pathogens platform pre-existing immunity Protein-based vaccines RBD Receptor binding domain Receptor-binding domain response SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike the RBD vaccination vaccine platform virus Virus-like particle VLP VLPs [DOI] 10.1016/j.ymthe.2022.02.011 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion세포 진입 및 면역 회피에 의한 SARS-CoV-2 변이체 B.1.617.1(카파), B.1.617.2(델타) 및 B.1.618의 특성화Article Published on 2022-04-262022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 ACE2 decoy receptor ACE2 orthologs ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alteration angiotensin antibody Antiviral B.1.617.1 B.1.617.2 B.1.618 binding binding affinity causative agent cell entry characterization cleavage contribute convalescent sera coronavirus COVID-19 Delta delta variant E484K Efficiency Entry inhibitor entry inhibitors examined exhibited facilitate highlight host tropism human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immune Immunity India Kappa variant L452R marmoset mouse Mutation neutralization neutralization antibodies Neutralization antibody neutralization titer Neutralizing antibodies neutralizing antibody P681R pandemic Patient receptor reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera significantly increased Spike protein Spike proteins Spread T478K the spike protein Transmissibility vaccinated individual vaccinated individuals variant variants viral entry wild-type [DOI] 10.1128/mbio.00099-22 PMC 바로가기 [Article Type] Article
mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2mRNA-1273 및 Ad26.COV2.S 백신은 SARS-CoV-2의 B.1.621 변이체로부터 보호합니다.Clinical and Translational Article Published on 2022-04-152022-09-14 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] in vivo vaccine efficacy studies Abstract ACE2 acute respiratory syndrome Ad26.COV2.S Ad26.COV2.S vaccine adenoviral-vectored vaccine AMED animal models B.1.621 center Context coronavirus D614G D950N development disease E484K Efficacy evaluated finding funding greater transmissibility hamster hamsters High dose Immunity immunization induce Infectious disease Infrastructure Innovation Japan Johnson & Johnson Lung infection Lung pathology mice Moderna mRNA vaccine mouse mRNA-1273 mRNA-1273 vaccine N501Y Neutralizing antibodies neutralizing antibody New NIAID NIH omicron P681H Program PROTECT reduced response SARS-CoV-2 SARS-CoV-2 strain Serum neutralizing antibody spike mutation supported Syrian hamster transgenic mice Vaccine variant variant of SARS-CoV-2 variants of SARS-CoV-2 viral variant virus WA1/2020 weight loss [DOI] 10.1016/j.medj.2022.03.009 PMC 바로가기 [Article Type] Clinical and Translational Article
Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants순환하는 SARS-CoV-2 변이체의 종간 친화성 및 항원 지형Article Published on 2022-03-222022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Alter Amino acid amino acids antigenic Cell change circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants circulating variant coronavirus CP: Immunology CP: Microbiology cross-species tropism cumulative driver expressing ferret Forecasting host tropism humans immunology Infection investigated less Microbiology mouse mutant Mutation mutations neutralization neutralization resistance Neutralizing antibodies omicron parameter positive correlation Prevalence RBD RBD mutation RBD mutations respiratory SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike receptor-binding domain susceptible variant variants variants of concern variants of interest Viral viral infectivity VOCs VOIs [DOI] 10.1016/j.celrep.2022.110558 PMC 바로가기 [Article Type] Article
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse ModelsRemdesivir 대사 산물 GS-441524, 마우스 모델에서 SARS-CoV-2 감염을 효과적으로 억제Article Published on 2022-02-242022-09-11 Journal: Journal of medicinal chemistry [Category] MERS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved cell lines challenge conducted coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 Diseases drug drug candidate Effectiveness food global pandemic GS-441524 Health Organization Hepatitis infected organs inhibit manuscript mice Model mouse murine hepatitis virus notable nucleoside organ outbreak parent nucleoside question reducing Remdesivir Replication replication of SARS-CoV-2 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Solidarity trial Spread Support the United State Toxicity treating Treatment United States United States Food and Drug Administration Vero E6 Viral viral titer viral titers World Health Organization [DOI] 10.1021/acs.jmedchem.0c01929 PMC 바로가기 [Article Type] Article
A Simplified SARS-CoV-2 Mouse Model Demonstrates Protection by an Oral Replicon-Based mRNA Vaccine단순화된 SARS-CoV-2 마우스 모델은 경구 레플리콘 기반 mRNA 백신에 의한 보호를 보여줍니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] addition Adenovirus angiotensin anti-SARS-CoV-2 carried characteristic cross-protective determine domain drug epitope Epitopes expressing expression forest gene delivery glycoprotein hACE2 heptad repeat human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunized mice immunohistochemistry in vitro in vivo Infectious disease Infectious diseases interstitial pneumonia lab lung Lung disease Lung pathology Lungs Macrophage macrophages membrane membrane glycoprotein mice Model moderate Molecular biology mouse mouse model mRNA mRNA expression mRNA vaccine murine Neutralizing antibodies neutralizing antibody nine nsp13 oral parental peptide peptides protection purification qPCR RBD Receptor binding domain recorded RT-PCR Salmonella SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mouse model Support supported target the SARS-CoV-2 therapy transduced transducing transduction utility Vaccine Vaccine design Vaccines variant Viral viral replication virus was determined weight loss were assessed [DOI] 10.3389/fimmu.2022.811802 PMC 바로가기 [Article Type] Immunology
Reduction of Cell Fusion by Deletion in the Hypervariable Region of the Spike Protein of Mouse Hepatitis VirusArticle Published on 2022-02-152022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Brain Cell fusion cells Characteristics characterized CPE CPEs cultured cells DBT Deletion Effect explain expression level fusion greater growth highlighting hypervariable region in viral involved luciferase activity MHV mouse mouse hepatitis virus Pathogenesis produced reduction Region several variant significantly higher spike gene strain Strains the Spike the spike protein virus growth [DOI] 10.3390/v14020398 PMC 바로가기 [Article Type] Article
MAIT cells in respiratory viral infections in mouse and humanReview Published on 2022-02-042023-06-14 Journal: Critical reviews in immunology [Category] MERS, [키워드] COVID-19 Human Infection Innate mouse Mucosal-associated invariant T cell review T cells virus [DOI] 10.1615/CritRevImmunol.2021040877 PMC 바로가기 [Article Type] Review
Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-BSARS-COV-2 mRNA 백신 PTX-Covid19-B의 전임상 평가Research Article Published on 2022-01-192022-09-10 Journal: Science Advances [Category] 변종, 비임상, 신약개발, 진단, [키워드] adverse effect adverse effects Alpha Beta breath candidate Cellular immune response clinical trial clinical trials COVID-19 pandemic Delta description effective effective vaccine elicited Gamma hamster hamsters Health Canada humoral immune immune responses immunogenic indicated initial lineages lung mice mouse mRNA vaccine neutralize Neutralizing antibody response Phase 2 Preclinical respiratory robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sera the strongest upper respiratory tract vaccination [DOI] 10.1126/sciadv.abj9815 PMC 바로가기 [Article Type] Research Article
ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologyACE2는 TNF- 및 IFNγ-유도 면역병리학을 가진 새로운 COVID-19 마우스 모델에서 SARS-CoV-2에 대한 중요한 생체 내 수용체입니다Research Article Published on 2022-01-132022-09-12 Journal: eLife [Category] 진단, [키워드] ACE2 adaptive BALB/c C57BL/6 COVID-19 COVID-19 mouse model COVID-19 therapy Critical Cytokine storm dependent on disease severity Factor Genetic human disease IFNγ Immune cell infiltration Immunity immunological immunopathology in vivo inhibition Interaction lymphopenia maVie16 mice mouse mouse-adapted SARS-CoV-2 murine Mutation pathology Pneumonia prevented Proinflammatory cytokine receptor recombinant ACE2 recombinant soluble ace2 reduced replicated resulting SARS-CoV-2 spike therapy TNF Treatment [DOI] 10.7554/eLife.74623 PMC 바로가기 [Article Type] Research Article