Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral InfectivitySARS-CoV-2 변이체의 스파이크 기능 분석, 중화 가능성 및 바이러스 감염성에서 뚜렷한 돌연변이의 역할 밝혀Article Published on 2022-04-132022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Affect Analysis approach carried circulating viral variants cleavage site conjunction COVID-19 defined Delta Disease progression dose E484K Efficacy enhanced escape FCS functional furin furin cleavage site furin–cleavage site in viral Infectivity Lota Mutation N501Y neutralization neutralization antibodies Neutralizing antibodies neutralizing antibody no effect no effects P681H P681R Pfizer Pfizer–BTN162b2 vaccine Potential promote pseudovirus pseudoviruses RBD RBD mutation RBD mutations Receptor binding domain receptor binding domain (RBD) reduce reveal role SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sera Site specific spike mutation specific spike mutations spike spike mutation spike mutations Spread vaccinated individuals Vaccine Viral viral infectivity Viral transmission viral variant Viral variants [DOI] 10.3390/v14040803 PMC 바로가기 [Article Type] Article
Molecular Dynamics and MM-PBSA Analysis of the SARS-CoV-2 Gamma Variant in Complex with the hACE-2 ReceptorhACE-2 수용체와 복합된 SARS-CoV-2 감마 변이체의 분자 역학 및 MM-PBSA 분석Article Published on 2022-04-062022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] accelerated adoption angiotensin angiotensin converting enzyme backbone binding affinity caused compensatory mutations complement complex deaths described dissect Dynamics E484K effective effort enzyme Evolution feature Gamma Gamma variant globe Government health institution infections Interaction knowledge MM-PBSA molecular molecular dynamics Molecular mechanics Mutation mutations N501Y observation P.1 pandemic Poisson polar interaction polar interactions promote Protective RBD receptor Receptor binding domain RECIPE Region residue residue specific interaction entropy. SARS-CoV-2 SARS-CoV-2 virus screened second wave South America Spike protein Spread surface area the RBD the SARS-CoV-2 the spike protein Treatment turn Vaccine variant variants variants of concern virus VoC’s [DOI] 10.3390/molecules27072370 PMC 바로가기 [Article Type] Article
The Role of Spike Protein Mutations in the Infectious Power of SARS-COV-2 Variants: A Molecular Interaction PerspectiveSARS-COV-2 변이체의 전염력에서 스파이크 단백질 돌연변이의 역할: 분자 상호작용 관점Article Published on 2022-04-052022-09-11 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor among others Analysis attachment B.1.1.28.1 B.1.351 bond Brazil correlated domain E484K mutation Effects Europe host cells hydrogen Hydrogen bond IMPROVE initial K417N molecular molecule molecules N501Y natural P.1 P.2 pair power quantum Quantum mechanics quantum theory RBD Receptor binding domain recognize reported residue residues role S477N Salt Bridge salt bridges SARS-CoV-2 virus significantly South Africa Specific spike Spike protein the spike protein theory United Kingdom variant virus wild type [DOI] 10.1002/cbic.202100393 PMC 바로가기 [Article Type] Article
Omicron variant (B.1.1.529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regionsSARS-CoV-2의 오미크론 변이체(B.1.1.529): 게놈, S-당단백질 및 항체 결합 영역의 돌연변이 이해Article Published on 2022-04-012022-09-11 Journal: GeroScience [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Ab binding region ACE2 affinity Amino acid amino acid substitution analyzed antibody antibody affinity B.1.1.529 binding D614G domain evaluated examined fusion peptide Genome H655Y Interaction K417N Mutation mutations N501Y Neutralizing antibodies neutralizing antibody New NTD omicron Omicron variant overlapping P681H peptide Region reveal S-glycoprotein. S477N Spike protein Spike proteins stability T478K variant [DOI] 10.1007/s11357-022-00532-4 PMC 바로가기 [Article Type] Article
In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8+ T cell reactivity and also signs of immune response escape새로운 SARS-CoV-2 계통에서 돌연변이 에피토프의 실리코 분석은 전 세계적으로 향상된 CD8+ T 세포 반응성과 면역 반응 탈출의 징후를 시사합니다Article Published on 2022-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Analysis antibody B.1.1.7 B.1.351 binding Binding prediction Brazil CD8+ CD8+ T cell CD8+ T cell response CD8+ T cells change class Class I HLA conserved country Coverage COVID-19 E484K epitope Epitopes evade Evidence exhibiting expected fraction highlight HLA allele HLA alleles HLA binding immune response immunogenic in silico individual investigated Lineage lineages mutant Mutation N501Y new SARS-CoV-2 P.1 P.2 peptide peptides predicted provided reactivity reference sequence respond response SARS-CoV-2 SARS-CoV-2 variants silico predictions South Africa spike T cell T cell epitopes T cells TCR Transmissibility variant variants variants of concern Viral load [DOI] 10.1016/j.meegid.2022.105236 PMC 바로가기 [Article Type] Article
Optimization and Application of a Multiplex Digital PCR Assay for the Detection of SARS-CoV-2 Variants of Concern in Belgian Influent Wastewater벨기에 유입 폐수에서 우려되는 SARS-CoV-2 변종 검출을 위한 다중 디지털 PCR 분석의 최적화 및 적용Article Published on 2022-03-152022-09-11 Journal: Viruses [Category] SARS, 변종, 치료기술, 치료제, [키워드] application applied approach B.1.1.7 B.1.351 B.1.617.2 Belgium Chain Reaction changes in complementary Concentration concern COVID-19 COVID-19 pandemic detect detection develop Digital digital polymerase chain reaction Epidemiology influent investigated limit of detection MONITOR multiplex Mutation N501Y National optimization PCR polymerase chain polymerase chain reaction proportion ranged SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant Spread strain Strains target variant variants variants of concern VoC wastewater Wastewater-based epidemiology wild-type [DOI] 10.3390/v14030610 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection after vaccination in Italian health care workers: a case reportShort Communication Published on 2022-03-062022-10-30 Journal: National Academy Science Letters. National Academy of Sciences, India [Category] COVID-19, [키워드] A570D Analysis antibody approval B.1.1.7 Care carried Case report Complete COVID-19 COVID-19 vaccination D614G Diseases EMA FIVE genetic variants genotyping Health healthcare healthcare worker Healthcare workers hospital identify immunization Infection Italian Italy mild COVID-19 symptoms Mild symptom N501Y Nasopharyngeal swab National outbreak Patient performed physician positive Post-vaccinal infection Protein RNA extract SARS-CoV-2 SARS-COV-2 infection sequence source of infection spike Surveillance swabs tested vaccination Vaccine variant variants VoC [DOI] 10.1007/s40009-022-01106-w PMC 바로가기 [Article Type] Short Communication
Evolution of the SARS-CoV-2 spike protein in the human hostArticle Published on 2022-03-042022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, [키워드] ACE2 binding ACE2 receptor acquisition Alpha Alpha variant B.1.1.7 B.1.351 Beta binding changes in cleavage Combination Cryoelectron microscopy D614G Delta dependent on Evolution examined furin site greater transmissibility human host humans K417N Mutation N501Y Neutralising Antibodies observation omicron receptor receptor ACE2 Receptor binding receptor-binding domains required SARS-CoV-2 SARS-CoV-2 spike spike spike glycoprotein Spike protein spike trimer stability Substitution the SARS-CoV-2 Transmission variant variant spike variants of concern variants of SARS-CoV-2 viral evolution virus virus pathogenesis [DOI] 10.1038/s41467-022-28768-w PMC 바로가기 [Article Type] Article
Antibody escape and global spread of SARS-CoV-2 lineage A.27SARS-CoV-2 계통의 항체 탈출 및 글로벌 확산 A.27Article Published on 2022-03-032022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] Amino acid amino acid substitution amino acid substitutions Analysis Antibody-mediated immunity bamlanivimab caused characterized convalescent D614G database described dominant escape Evolution Germany Immunity include independent Infection International L18F L452R lack Lineage monoclonal antibody mutations N501Y National neutralization assays novel lineage REGN-COV2 cocktail SARS-CoV-2 lineage SARS-CoV-2 variant sequence spike gene Spread spring therapeutic variants of concern [DOI] 10.1038/s41467-022-28766-y PMC 바로가기 [Article Type] Article
The evaluation of potential global impact of the N501Y mutation in SARS-COV-2 positive patientsSARS-COV-2 양성 환자에서 N501Y 돌연변이의 잠재적 글로벌 영향 평가Article Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect age Analysis approach average Chain Reaction Contagion contribute coronavirus evaluate examined FAM female global pandemic groups Health authority male medium Mutation mutation rate mutations N501Y N501Y mutation Patient PCR PCR test polymerase chain polymerase chain reaction Polymerase chain reaction (PCR) positive positive patient positive sample Precaution Public public health public health authorities quantitation Randomly ranged Rapid retrospective reverse transcription PCR reverse transcription PCR (RT-PCR). RT-PCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spread virus [DOI] 10.1002/jmv.27413 PMC 바로가기 [Article Type] Article