Neuropathology and Inflammatory Cell Characterization in 10 Autoptic COVID-19 BrainsArticle Published on 2021-08-312022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] addition Affect age Brain brain autopsy cause changes characterization Comorbidities COVID-19 COVID-19 patients described Encephalopathy feature Hemorrhagic highlighting hypoxic Infection Inflammation Injury knowledge Laboratory safety lesion macrophages microvascular injury nervous system neurological manifestations Neurological symptoms neuronal Neuropathology Patient perivascular inflammation Post-mortem SARS-CoV-2 SARS-COV-2 infection Support surviving patient T cell Vascular [DOI] 10.3390/cells10092262 PMC 바로가기 [Article Type] Article
Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, including Response to SARS-CoV-2, in Autism Spectrum DisorderReview Published on 2021-08-292022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] ACE2 activated Activation address affected allergens allergies Amygdala angiotensin-converting enzyme 2 anti-inflammatory cytokine approach ASD association Asthma atopic dermatitis autism Autism Spectrum Disorder binding block Brain changes children Comorbidity complicate COVID-19 Cytokines Deceased decreased expression disorder disrupting drug effective electrical Epidemiological study expression flavonoids Focal gestation IL-18 increased expression Inflammation Inflammatory inhibit inhibitor Luteolin mast cell Mast cells microglia mother neurodegenerative neuronal Pathogenesis Patient Perinatal Pregnancy Prevalence Proinflammatory cytokine receptor regulate reported response SARS-CoV-2 Spectrum Stress threshold tissue toxins Treatment triggered virus [DOI] 10.3390/jpm11090860 PMC 바로가기 [Article Type] Review
Transcriptomic Analysis of HCN-2 Cells Suggests Connection among Oxidative Stress, Senescence, and Neuron Death after SARS-CoV-2 InfectionHCN-2 세포의 전사체 분석은 SARS-CoV-2 감염 후 산화 스트레스, 노화 및 신경 세포 사멸 간의 연관성을 시사합니다Article Published on 2021-08-252022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis antioxidant Apoptosis blocking caspase caspase 3 CDK4 CDK6 CDKN2A Cell cell cycle cells cortical cell death decrease deregulation evaluate the effect explain followed by functions HCN-2 impairment increase in indicated KAT5 mechanism nervous system Neurological symptom Neurological symptoms Neuron neuronal neurons outcome oxidative stress pediatric PMAIP1 Potential treatment potential treatments Prevent PROTECT r death reduction reported required resulting ROS homeostasis SARS-CoV-2 SARS-COV-2 infection senescence SOD1 supported the cell Transcriptome transcriptomic analysis TXN upregulation virus western blot Western blot analysis [DOI] 10.3390/cells10092189 PMC 바로가기 [Article Type] Article
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입Immunology Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used [DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology
Pericytes: Intrinsic Transportation Engineers of the CNS MicrocirculationPhysiology Published on 2021-08-232022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Activation Alzheimer’s disease blood flow blood-brain barrier Brain capillary network cellular CNS contractile proteins Engineer function functional hyperemia identify identity Immune homeostasis mice Microcirculation neuronal Neurovascular neurovascular coupling oxygen pericyte pericytes positioned progeny regenerative medicine respond stroke subtype Therapeutic strategies [DOI] 10.3389/fphys.2021.719701 PMC 바로가기 [Article Type] Physiology
Organochlorine Pesticide Dieldrin Suppresses Cellular Interferon-Related Antiviral Gene ExpressionArticle Published on 2021-08-032023-06-24 Journal: Toxicological sciences : an official journal of th [Category] 신종인플루엔자, [키워드] Immunity Immunosuppression neuronal organochlorine pesticide reactive oxygen species [DOI] 10.1093/toxsci/kfab064
SARS-CoV-2 and the Brain: What Do We Know about the Causality of ‘Cognitive COVID?Review Published on 2021-08-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] approach Brain Causality caused changes in cognitive Cognitive impairment consequence coronavirus disease correlations COVID-19 COVID-19 case Deleterious delirium Diagnosis domains encephalopathy-like symptoms event Evidence exhibiting Healthcare system hematogenous highlight identify Immune cell Infection Inflammation intubation management mechanism mechanisms memory MERS-CoV mitigate mRNA neuronal neurotropism olfactory outbreak pandemic pathway Patient Prevalence prevention pro-inflammatory state proportion psychosocial stressor Quality of life raised rehabilitation risk SARS-CoV SARS-CoV-2 SARS-COV-2 infection spike glycoprotein Spread Symptom Symptoms syndrome Transmission unique Vaccine vectors virus [DOI] 10.3390/jcm10153441 PMC 바로가기 [Article Type] Review
The Immunopathogenesis of Neuroinvasive Lesions of SARS-CoV-2 Infection in COVID-19 PatientsNeurology Published on 2021-07-302022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] addition Brain cause cell death CNS consequence COVID-19 COVID-19 virus Cytokine storm death disease dysregulation Effect Effects IL-6 induce Infection Inflammation initial lesion mechanism mild infection neuroinvasive lesions neurological neuronal New coronavirus nuclei olfactory progression recent finding regulate reported SARS-CoV-2 SARS-CoV-2- Spread subject Transport virus [DOI] 10.3389/fneur.2021.697079 PMC 바로가기 [Article Type] Neurology
Neurochemical signs of astrocytic and neuronal injury in acute COVID-19 normalizes during long-term follow-up급성 COVID-19에서 성상세포 및 신경세포 손상의 신경화학적 징후는 장기 추적 관찰 중에 정상화됩니다Research Paper Published on 2021-07-292022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 바이오마커, 진단, [키워드] accompanied Acidic acute COVID-19 acute phase analysed association Biomarker Biomarkers blood sample Blood samples changes in Clinical research CNS Cognition collected Concentration Control controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 determine disease severity fatigue feature finding Follow-up foundation funding GDF-15 GFAp group growth indicate individual individuals Injury IQR Knut Long-term follow-up manifestation median Mild moderate moderate disease Neurochemical neurologic neurological Neurological symptom Neurological symptoms neuronal NfL no correlation normalization normalized Patient plasma biomarker plasma concentration plasma concentrations Protein provided reported SARS-CoV-2 severe COVID-19 significantly increased state Swedish the disease were recorded [DOI] 10.1016/j.ebiom.2021.103512 PMC 바로가기 [Article Type] Research Paper
SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in PathogenesisSARS-CoV-2에 감염된 소아 대뇌 피질 뉴런: 전사체 분석 및 병인에서 유료 유사 수용체의 잠재적 역할Article Published on 2021-07-282022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] ACE2 caspase caspase 8 cells cerebral changes in chemokine chemokines children cortical COVID-19 neurological symptom COVID-19 neurological symptoms deregulation downregulated downregulation downstream ERK expression genes encoding human neuronal cells IKKε increase in increased expression infect infected with SARS-CoV-2 IRF3 JNK mechanism medium nervous system Neurological involvement Neurological symptoms Neuron neuronal next generation sequencing NF-κB Nod-like receptors not express Pathogenesis Pattern recognition pattern recognition receptor pediatric Potential receptor receptors replicate responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins scavenger receptors Sequencing Signaling TLR TLR1 TLR4 TLR6 TLRs TMPRSS2 Toll-like receptor Toll-like receptors TRAF3 transcriptomic analysis transcriptomic profile upregulated upregulation Viral Viral RNA western blot [DOI] 10.3390/ijms22158059 PMC 바로가기 [Article Type] Article