The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/AccumulationArticle Published on 2021-12-302022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 229E accompanied addition Adenovirus alteration Altering amplification blocked Cell cellular changes in coronavirus described dose drastic Factor Gene Expression HIV-1 HIV-1 replication Impact inhibited inhibitor involved Loss multiple coronaviruses OC43 Prevent protein expression Proteins reduced Regulatory Replication retained RNA RNA processing RNAs SARS-CoV2 selective Toxicity Treatment viability viral DNA viral gene expression Viral RNA virus virus particles [DOI] 10.3390/v14010060 PMC 바로가기 [Article Type] Article
Complement Inhibitors Vitronectin and Clusterin Are Recruited from Human Serum to the Surface of Coronavirus OC43-Infected Lung Cells through Antibody-Dependent MechanismsArticle Published on 2021-12-242022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Activation Alter antibody C5a Cell cells circulating CLU clusterin complement complex coronavirus CoV dominant experiment host cell Human human coronavirus human lung cell human serum IgG implication in vitro infected cell Infection inhibitor inhibitory killing lung membrane OC43 parainfluenza virus Pathogenesis prevalent public health purified recruitment robust serum surface treated Treatment viability virus Vitronectin [DOI] 10.3390/v14010029 PMC 바로가기 [Article Type] Article
Microarray-Based Detection of Antibodies against SARS-CoV-2 Proteins, Common Respiratory Viruses and Type I InterferonsArticle Published on 2021-12-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] absence analyzed anti-SARS-CoV-2 antibody antibody cross-reactivity Antibody Response applied autoantibodies to interferons autoantibody Autoimmune Betacoronavirus Cohort common Contact convalescent plasma Coronaviruses COVID-19 COVID-19 patient cross-reactivity detect detection disorders donors ELISA Endocrine healthy individual heterogeneous HKU1 ICU ICU Patients identify IFN-I IFN-Is IgG IgG and IgM IgM antibody ill patient intensive care marker MERS Microarray Multiplex analysis Multiplex assay nucleocapsid OC43 other respiratory virus pandemic Patient positive protein microarray RBD recipients respiratory respiratory viruses resulting SARS-CoV-2 serum sample severe COVID-19 Spike protein the SARS-CoV-2 Type type I interferon Vaccine virus viruses [DOI] 10.3390/v13122553 PMC 바로가기 [Article Type] Article
Exploring the diversity of coronavirus in sewage during COVID-19 pandemic: Don’t miss the forest for the treesCOVID-19 전염병 동안 하수에서 코로나바이러스의 다양성 탐구: 나무를 위한 숲을 놓치지 마세요Article Published on 2021-12-152022-09-11 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] analyzed animal coronavirus Animal host applied approach Characteristics circulation clinical samples contig Coronaviridae Coronaviridae family coronavirus CoV COVID-19 COVID-19 pandemic CoVs detect enrichment Genetic HCoV HCoV-OC43 infecting next generation sequencing NGS OC43 Occurrence pandemic protocol rodents SARS-CoV-2 sequenced Sequencing sewage Sewage virome specimen target Target enrichment sequencing typing Viral metagenomics. virus wake was obtained wastewater [DOI] 10.1016/j.scitotenv.2021.149562 PMC 바로가기 [Article Type] Article
Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody responseArticle Published on 2021-12-072023-06-18 Journal: Cell Host & Microbe [Category] Fulltext, SARS, [키워드] 229E antibody COVID-19 HKU1 NL63 OC43 pre-existing immunity SARS-CoV-2 [DOI] 10.1016/j.chom.2021.12.005 PMC 바로가기 [Article Type] Article
Risk Factors for Healthcare Personnel Infection With Endemic Coronaviruses (HKU1, OC43, NL63, 229E): Results from the Respiratory Protection Effectiveness Clinical Trial (ResPECT)풍토성 코로나바이러스(HKU1, OC43, NL63, 229E)에 의한 의료인 감염의 위험 요소: 호흡기 보호 효과 임상 시험(ResPECT)의 결과Randomized Controlled Trial Published on 2021-12-062022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료기술, [키워드] 229E 95% confidence interval activity acute respiratory syndrome acute respiratory syndrome coronavirus aerosol aerosol generating procedure aerosol-generating procedure age AGP AGPs Analysis association cause Characteristics clinical Cluster conducted coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 diagnosed Endemic Factor hcp healthcare personnel HKU1 increase increased risk individuals laboratory-confirmed NL63 OC43 participated Participation Pediatric patients Personal protective equipment Prevent protection randomized trial respiratory respiratory infection respiratory infections Result risk Risk factors SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Trial viral respiratory virus [DOI] 10.1093/cid/ciaa900 PMC 바로가기 [Article Type] Randomized Controlled Trial
Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2Research Paper Published on 2021-11-302023-06-15 Journal: EBioMedicine [Category] MERS, SARS, [키워드] 229E COVID-19 HKU1 human coronaviruses NL63 OC43 pre-existing immunity SARS-CoV-2 seasonal coronavirus [DOI] 10.1016/j.ebiom.2021.103700 PMC 바로가기 [Article Type] Research Paper
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structuresResearch Article Published on 2021-11-262022-11-01 Journal: Science Advances [Category] COVID-19, [키워드] Amiloride Antiviral antivirals conserved coronavirus CoV description docking element genomes in vitro inhibit inhibit SARS-CoV-2 Interaction likelihood OC43 offer Pandemics predicted probe proximal Region Replication retrospective reveal RNA RNA structure SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication small molecule Structure target therapeutic virus replication [DOI] 10.1126/sciadv.abl6096 PMC 바로가기 [Article Type] Research Article
Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its first variants in fourplex real-time quantitative reverse transcription-PCR assaysResearch Report Published on 2021-11-252022-10-30 Journal: Microbial Cell [Category] COVID-19, [키워드] 229E acute respiratory syndrome amplification amplify approach B2M circulating circulating variant clinical sample coding sequence contagious coronavirus COVID-19 detection dominant early diagnosis Efficacy envelope evaluated exhibited False-positive Genes genetic variants human coronavirus identify Infection Internal control linear locked nucleic acid (LNA) molecular diagnostics mutant Mutation nine NL63 nucleic acid nucleotide OC43 pandemic Patient populations positive Prevent primer-probe set probe quantified Quantitative real-time TaqMan reverse transcription PCR assays required Respiratory pathogens Result reverse transcription PCR reverse transcription-PCR RNA transcripts rRT-PCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral RNA selective sequence spike Spread TaqMan the Spike transmission of SARS-CoV-2 variant viral strain virus wild-type [DOI] 10.15698/mic2022.01.767 PMC 바로가기 [Article Type] Research Report
Evaluation of human coronavirus OC43 and SARS‐COV‐2 in children with respiratory tract infection during the COVID‐19 pandemicResearch Article Published on 2021-11-242022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] acute respiratory syndrome center Characteristics children Contact coronavirus coronavirus disease Coronaviruses COVID‐19 determine distribution edema Endemic evaluate Fever flexible Frequency HCoV‐OC43 headache human coronavirus human coronavirus OC43 Infection Iran Lymphocyte count median mild respiratory symptoms myalgia OC43 pandemic Patient performed positive positive PCR recruit regions Research respiratory symptom respiratory tract infection responsible RT‐PCR SARS‑CoV2 SARS‐CoV‐2 significant difference significantly higher significantly lower Tehran two group Two patient viruses vomiting [DOI] 10.1002/jmv.27460 PMC 바로가기 [Article Type] Research Article