Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19COVID-19로 입원한 성인을 대상으로 한 플리티뎁신의 전임상 및 무작위 1상 연구Clinical Trial Published on 2022-01-102022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, 비임상, 신약개발, 임상, [키워드] adults hospitalized adverse event adverse events affecting baseline breath Concentration conducted Consent diarrhea died dose elongation factor End points eukaryotic translation grade 3 hospital hospitalized patient host protein hypersensitivity inhibit initiated intensive care intensive care support invasive ventilation log lung Mortality nausea once daily one patient Open-label Patient patients with COVID-19 peptide Phase I plasma Plitidepsin Preclinical preclinical studies Randomized required respiratory Respiratory Support safety profile SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 variant Spanish Support Treatment Viral Viral load viral load reduction vomiting with COVID-19 [DOI] 10.26508/lsa.202101200 PMC 바로가기 [Article Type] Clinical Trial
Antemortem vs Postmortem Histopathologic and Ultrastructural Findings in Paired Transbronchial Biopsy Specimens and Lung Autopsy Samples From Three Patients With Confirmed SARS-CoV-2SARS-CoV-2가 확인된 3명의 환자로부터 한 쌍의 경기관지 생검 표본 및 폐 부검 샘플에서 사후 조직병리학적 및 미세구조적 소견 비교Article Published on 2022-01-062022-09-11 Journal: American journal of clinical pathology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alveolar alveolar damage Antemortem ARDS Autopsies Autopsy biopsy cause of death Chain Reaction change clinical evaluation Computed tomography Confirmed coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19-induced lung injury DAD death detectable died different time point different time points diffuse Diffuse alveolar damage disease enrolled fibrosis finding Fluorescence High-resolution histology Hospital admission In situ hybridization latency lung Lung fibrosis Lung injury Lung pathology one patient Organizing pneumonia pathologic Patient patients with COVID-19 performed pneumocyte Pneumonia polymerase chain polymerase chain reaction Postmortem progression reactive respiratory Respiratory failure reverse transcription reverse transcription polymerase chain reaction Sample SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen Spread TBB the disease the patient tissue sample transbronchial upper airway upper airways Vascular Viral Viral load virus widespread [DOI] 10.1093/ajcp/aqab087 PMC 바로가기 [Article Type] Article
Multisystem inflammatory syndrome in children associated with SARS-CoV-2: extracardiac radiological findingsFull Paper Published on 2022-01-012022-10-27 Journal: The British Journal of Radiology [Category] COVID-19, [키워드] abdomen acute respiratory syndrome advance age bowel Brain callosum Chest Chest CT Chest radiograph children coronavirus corpus deep neck infection diagnosed Diagnosis diffusion edema feature female hepatosplenomegaly Infection Inflammation Inflammatory Lymphadenopathy male manifestation medical record MIS-C MRI non-specific one patient Pathologies Patient patients periportal pulmonary radiological radiological finding radiologist retrospective SARS-CoV-2 syndrome Thorax was determined [DOI] 10.1259/bjr.20210570 PMC 바로가기 [Article Type] Full Paper
Lung transplantation for severe COVID-19-related ARDSObservational Study Published on 2022-01-012022-10-05 Journal: Therapeutic Advances in Respiratory Disease [Category] SARS, 임상, [키워드] acute respiratory distress ARDS chronic lung disease collected coronavirus disease COVID-19 dysfunction ECMO effective expired extracorporeal membrane oxygenation extracorporeal membrane oxygenations Follow-up frailty gold standard IQR Korean lung lung transplantation management median median age membrane multicenter one patient outcome Patient registry rehabilitation retrospective Sepsis South Korea supported syndrome therapeutic option transplantation Treatment outcome two groups was performed [DOI] 10.1177/17534666221081035 PMC 바로가기 [Article Type] Observational Study
Hematopoietic Cell Transplantation is Feasible in Patients with Prior COVID-19 Infection이전 COVID-19 감염 환자에서 조혈 세포 이식이 가능합니다Article Published on 2022-01-012022-09-11 Journal: Transplantation and cellular therapy [Category] SARS, 치료기술, [키워드] Acute lymphoblastic leukemia acute myelogenous leukemia Allogeneic anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody autologous Cell cell transplantation Characteristics chronic myelogenous leukemia Cohort consecutive patient coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 disease COVID-19 infection Descriptive statistics detectable Diagnosis died disease eight Follow-up fungal Graft-versus-host disease HCT Hematologic malignancy hematopoietic Hematopoietic cell transplantation IgG antibodies IgG antibody Infection initial leukemia Lymphoblastic leukemia lymphoid lymphoma Multiple myeloma Myelodysplastic syndrome myelofibrosis myelogenous leukemia Myeloma one patient outcome Patient patients with asymptomatic performed Pneumonia positive progression of disease recurrence remained retained Retrospective analysis SARS CoV SARS CoV-2 SARS Cov-2 antibody seroconversion. selected Seroconversion Seven susceptible symptomatic COVID-19 disease syndrome tested transplantation Treatment were used [DOI] 10.1016/j.jtct.2021.10.004 PMC 바로가기 [Article Type] Article
COVID-19 in Recent Lung Transplant Recipients: Clinical Outcomes and Management StrategiesArticle Published on 2022-01-012022-10-05 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료제, [키워드] advanced age antibody antiviral therapy cause change clinical Clinical course Cohort Comorbidity convalescent plasma COVID-19 COVID-19 infection death disease General population high risk Hospital stay immune incidence Infection infection with COVID-19 Laboratory lung lung transplant management medication Munich obesity one patient outcome outcomes Patient patients Premature receive recent recipient Remdesivir responsible Result risk factor SARS-COV-2 infection severe respiratory failure severity solid organ transplants Strategy suffered susceptible Symptoms the patient the SARS-CoV-2 Transplant Treatment viral infection [DOI] 10.1016/j.transproceed.2021.12.014 [Article Type] Article
Outcome of SARS-CoV-2 variant breakthrough infection in fully immunized solid organ transplant recipients완전 면역된 고형장기 이식 환자에서 SARS-CoV-2 변이형 돌발성 감염 결과Article Published on 2022-01-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 변종, [키워드] Admission Alpha variant Beta Beta variant BNT162b2 BNT162b2 mRNA Breakthrough infection breakthrough infections Case series case sery ChAdOx1 circulating COVID-19 vaccines delta variant died Efficacy Future immune response immunized intensive care nasal observation older patients one patient outcome oxygen Patient Pfizer-BioNTech Post-vaccine recipient recipients required risk SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 variant SARS-CoV-2 variants SARSCoV-2 SARSCoV-2 variant of concern Saudi Arabia severe pneumonia solid organ solid organ transplant Solid organ transplant recipients solid organ transplants supplemental oxygen Two patient two patients vaccination Vaccine variant ventilatory support were infected younger patients [DOI] 10.1016/j.jiph.2021.11.021 PMC 바로가기 [Article Type] Article
A Comparison of SARS-COV-2 Neutralizing Antibody Therapies in High-Risk Patients with Mild to Moderate COVID-19 Disease at a Single Academic Hospital단일 학술 병원에서 경증에서 중등도의 COVID-19 질병을 가진 고위험 환자의 SARS-COV-2 중화 항체 요법의 비교Article Published on 2022-01-012022-09-12 Journal: The Journal of emergency medicine [Category] SARS, 진단, [키워드] addition Adverse adverse events bamlanivimab bamlanivimab, casirivimab/imdevimab, REGN-CoV-2 coronavirus disease COVID-19 criteria deaths decrease died Efficacy and safety event feature group Hospitalization hospitalizations in both groups LY-CoV555 monoclonal antibodies monoclonal antibody neutralizing monoclonal antibody occurred one patient Open-label outcome Patient patients with COVID-19 performed Primary outcome Prospective Study reaction single-center statistically significant difference subsequent Symptom Therapies therapy Treatment Viral load [DOI] 10.1016/j.jemermed.2021.07.025 PMC 바로가기 [Article Type] Article
Multisystem inflammatory syndrome in children during severe acute respiratory syndrome coronavirus-2 pandemic in Turkey: A single-centre experience터키의 중증 급성 호흡기 증후군 코로나바이러스-2 대유행 중 어린이의 다기관 염증 증후군: 단일 센터 경험Article Published on 2022-01-012022-09-11 Journal: Journal of paediatrics and child health [Category] SARS, 치료기술, [키워드] acute anterior uveitis acute respiratory syndrome acute respiratory syndrome coronavirus Anakinra Anterior uveitis approach cardiovascular Child child health children Clinical finding Clinical findings Clinical presentations Coronary artery Coronavirus-2 deep neck infection demographics diagnosed disease duration of hospitalisation enrolled eruption Fever FIVE Gastrointestinal hematologic Henoch-Schönlein Purpura hospitalisation Hyperinflammatory Immunoglobulin induration Infection Inflammatory interquartile interquartile range Intravenous immunoglobulin laboratory characteristics life-threatening Lymph node male maternity median median age Methylprednisolone MIS-C multisystem inflammatory syndrome associated with COVID-19. Neck pain nine one patient pandemic Patient patients performed positive Retrospective study SARS-CoV-2 serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 swelling syndrome training Treatment Treatment outcome trismus Turkey Two patient two patients Uveitis was used with COVID-19 [DOI] 10.1111/jpc.15674 PMC 바로가기 [Article Type] Article
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis of Early COVID-19 and Treated at Home Within 3 Days or After 3 Days of Symptom Onset with Prescribed and Non-Prescribed Treatments Between November 2020 and August 20212020년 11월에서 2021년 8월 사이에 초기 COVID-19 진단을 받고 증상 발병 3일 이내 또는 3일 후 집에서 치료를 받은 이탈리아에서 처방 및 비처방 치료를 받은 환자의 결과 및 입원율에 대한 후향적 연구Observational Study Published on 2021-12-302022-09-12 Journal: Medical science monitor : international medical jo [Category] SARS, 임상, 진단, [키워드] alteration analyzed Aspirin association chest X-ray clinical clinical variable Cohort Community Confirmed COVID-19 D-dimer levels Day Diagnosis duration of symptom early diagnosis evaluated groups home Hospitalization increase in Italian patient Italy Logistic regression low-dose management median medical record occurred one patient Onset onset of symptoms outcome Patient patients Rate reduced Retrospective study risk severity severity of COVID-19 symptom duration therapy treated Treatment [DOI] 10.12659/MSM.935379 PMC 바로가기 [Article Type] Observational Study