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[키워드] 3CL pro accessory proteins acute respiratory syndrome anti-coronavirus activity antibody anticipated antiviral agent antiviral drug antiviral drugs antiviral strategy approved artificial intelligence asymptomatic infection betacoronaviruses can be used catalytic site cause cellular receptor China circulating Clinical effect common cold conserved Coronaviridae coronavirus COVID-19 COVID-19 disease COVID-19 epidemic current deaths develop direct-acting antiviral disease drug Drug discovery drugs drugs targeting effort ENCODE engage enzyme etiological agent fatality Genome genomic sequence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Helicase High Throughput Screening highlight host-targeting antiviral identify immuno-regulator in viral in vitro in vivo include infections Infectious disease involved Jin membrane MERS MERS-CoV Mild monoclonal antibodies morbidity and mortality Neurological disease neutralizing antibody new treatment strategy non-structural protein outbreak pandemic pandemic disease Papain-like protease peptides phenotypic Prevent previous study protease public health RdRP recognize Region Remdesivir Replication reported respiratory syndrome coronavirus RNA virus RNA-dependent RNA polymerase SARS CoV SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe pneumonia severity shown similarity spike glycoprotein strain Strategy structural protein structural proteins Structure target the disease the epidemic the SARS-CoV-2 Transcription treating COVID-19 upper respiratory tract urgency US FDA viral entry viral infections viral infectious disease WHO World Health Organization
[DOI] 10.3389/fmolb.2021.671263 PMC 바로가기 [Article Type] Molecular Biosciences