A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19COVID-19 환자의 바이러스 운반에 대한 하이드록시클로로퀸과 아지트로마이신의 영향에 대한 베이지안 재분석Comparative Study Published on 2021-02-192022-09-10 Journal: PLoS ONE [Category] MERS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyses applied assumed assumption Azithromycin Bayesian case sery coronavirus dual Effect effective Effects Evidence examined exclusion HCQ Hydroxychloroquine include Inclusion Interpretation moderate monotherapy no effect paper Patient patients patients with COVID-19 performed positive raise ranged reducing reduction reported respiratory robustness SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 statistical the patient These data Treatment upper respiratory tract variant variants Viral Viral load virus were excluded [DOI] 10.1371/journal.pone.0245048 PMC 바로가기 [Article Type] Comparative Study
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new IssueCOVID-19 관련 사이토카인 폭풍 증후군 및 진단 원칙: 오래된 문제와 새로운 문제Review Published on 2021-02-182022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen Autoimmune disease Autoimmune diseases autologous benefit Bone marrow CAR-T Characteristics chimeric chimeric antigen receptor claimed clinical experience Clinical sign Clinical signs clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRS CSS cytokine cytokine release Cytokine release syndrome Cytokine storm Cytokine storm syndrome Cytokines Deterioration diagnosed diagnoses diagnosing Diagnosis diagnostic Diagnostic Criteria disease early stage early stages Evolution familial/primary hemophagocytic lymphohistiocytosis hemophagocyte hemophagocytic lymphohistiocytosis hemophagocytic syndrome HLH include issue less limitation Macrophage macrophage activation macrophage activation syndrome malignancy mechanisms non-specific paper Pathogenesis Patient Research respiratory SARS-CoV-2 secondary hemophagocytic lymphohistiocytosis sensitivity severe acute respiratory syndrome Coronavirus sHLH Signs and symptoms Symptoms T-cell T-cell receptor therapy [DOI] 10.1080/22221751.2021.1884503 PMC 바로가기 [Article Type] Review
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptorIpomoeassin-F는 SARS-CoV-2 스파이크 단백질과 숙주 세포막 수용체의 시험관 내 생합성을 억제합니다125 Published on 2021-02-152022-09-10 Journal: Journal of Cell Science [Category] MERS, 치료제, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents assembly biogenesis biosynthetic block causative agent Cell-free translation component COVID-19 Endoplasmic reticulum envelope enzyme ER membrane ER membrane complex highlight highlighting Host host cell host cell membrane human cell in vitro inhibit inhibitor insertion mechanisms membrane protein Membrane proteins ORF8 protein ORF8 proteins paper pathogenic pathogenicity Pathogens Person plasma membrane Protein Protein target receptor reducing respiratory Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Sec61 Sec61 translocon small molecule Spike protein structural proteins synthesised the SARS-CoV-2 therapeutic translocation Viral Viral particles viral pathogens Viral protein biogenesis viral spike viruses [DOI] 10.1242/jcs.257758 PMC 바로가기 [Article Type] 125
D-Dimer-Driven Anticoagulation Reduces Mortality in Intubated COVID-19 Patients: A Cohort Study With a Propensity-Matched AnalysisMedicine Published on 2021-02-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Administered Analysis anticoagulation appear benefit bleeding event control group COVID-19 COVID-19 disease Critical D-dimer D-dimer level D-dimer levels D-dimer-driven anticoagulation Effect Escalation groups hypercoagulability ICU patient ICUs Infection intensive care unit Intubated intubated patient intubated patients kidney dysfunction Mortality organ dysfunction organ function outcome overall mortality paper Patient patients patients treated patients with COVID-19 performed protocol provide Safe serum serum creatinine Severe COVID-19 Infection shown significantly lower standard thromboprophylaxis stratified subject survival thromboembolic complication Thromboprophylaxis thrombotic complication Thrombotic complications transfusion treated university with COVID-19 [DOI] 10.3389/fmed.2021.631335 PMC 바로가기 [Article Type] Medicine
Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19COVID-19 환자의 복합 요법에서 조혈모세포 분화 활성화제를 사용한 결과 및 전망Article Published on 2021-02-012022-09-11 Journal: Stem cell reviews and reports [Category] 유전자 메커니즘, [키워드] accelerated activator addition biological activity blood clot Blood clots C-reactive protein carbon complex Concentration control group Coronavirus infection COVID-19 COVID-19 patients cytokine D-dimer decrease differentiation hematopoietic Hematopoietic stem cell hematopoietic stem cells Hemostasis hydrogen hydrogen atom hydrogen atoms IL-6 Immunity immunomodulatory effect Inclusion mechanism nitrogen oxygen paper Patient patients with COVID-19 peptide peptides phosphorus pro-inflammatory cytokine pro-inflammatory cytokine IL-6 rationale reduce Result risk SARS-CoV-2 virus shown Standard Standard therapy standard treatment STEM T cell Thymalin. Treatment treatment method with COVID-19 [DOI] 10.1007/s12015-020-10087-6 PMC 바로가기 [Article Type] Article
Bedside teaching without bedside – an introduction to clinical reasoning in COVID-19 times병상 없는 병상 교육 – COVID-19 시대의 임상 추론 소개Article Published on 2021-01-282022-09-12 Journal: GMS Journal for Medical Education [Category] 진단, [키워드] bedside teaching BST Clinical Reasoning Cohort compensating Corona virus COVID-19 differential diagnosis directive facilitate feasible form introduced online cases outcome pandemic paper Patient patients positive PROTECT provided response student Teaching [DOI] 10.3205/zma001410 PMC 바로가기 [Article Type] Article
T cell response to SARS-CoV-2 infection in humans: A systematic reviewResearch Article Published on 2021-01-252022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Adults antibody article Asymptomatic carried complex Consensus COVID-19 COVID-19 case Critical Critical disease cross-reactive demonstrated develop disease disease severity epidemiological Epitopes evaluate feasible finding heterogeneity hospitalised patient Immunity individuals Inference involved lack limitations majority methodological limitation paper pauci-symptomatic peer-reviewed population level preserved recipients Research researcher researchers responses Result RNA robust SARS-CoV-2 SARS-COV-2 infection screened Surveillance susceptibility synthesised systematic review T cell lymphopenia T cell memory T cell response understanding uninfected unlikely Vaccine Vaccine development virus-specific T cell [DOI] 10.1371/journal.pone.0245532 PMC 바로가기 [Article Type] Research Article
Xuan Fei Bai Du Fang for treating coronavirus disease 2019 A protocol for systematic review and meta-analysis2019년 코로나바이러스 질병 치료를 위한 Xuan Fei Bai Du Fang 체계적인 검토 및 메타 분석을 위한 프로토콜4900 Published on 2021-01-082022-08-31 Journal: Medicine [Category] meta-analysis, 치료제, [키워드] calculated China Clinical effect Cochrane Library confirmed case coronavirus disease Coronavirus disease 2019 country COVID-19 criteria cure rate database death Diagnosis disease effective Effectiveness Efficacy and safety evaluate evaluated Evidence expressed Fang Fatality rate fixed funnel plots GRADE framework heterogeneity import information Infrastructure intent-to-treat mean difference member Meta-analysis nucleic acid nucleic acid test nucleic acid tests paper peer-reviewed positive primary and secondary outcomes protocol publication bias Quality random effect random effect model Randomized controlled studies randomized controlled study Randomized controlled trial Relative risk relative risks Research respiratory respiratory infectious disease risk of bia Risk of bias searched secondary outcome selected systematic review treat treated Treatment treatment methods treatment of COVID-19 were assessed Xuan Fei Bai Du Fang [DOI] 10.1097/MD.0000000000023485 PMC 바로가기 [Article Type] 4900
A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro새로운 가상 스크리닝 절차는 Pralatrexate를 SARS-CoV-2 RdRp의 억제제로 식별하고 시험관 내 바이러스 복제를 감소시킵니다.Research Article Published on 2020-12-312022-08-13 Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS, [키워드] 2019-nCoV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alternative method alternative methods anti-viral drug applied approved drugs Azithromycin conditions coronavirus COVID-19 deep learning demonstrated develop disease drug drug candidates drug candidates targeting Drug screening drugs EC50 value EC50 values effective drug effective drugs FDA-approved drug feasibility global public health hybrid drug identify in vitro inhibit inhibit SARS-CoV-2 inhibitor inhibitors inhibitors of SARS-CoV-2 inhibitory activity lack leads molecular dynamics Molecular dynamics simulation No effective drug Novel coronavirus paper potential therapeutic agent potential therapeutic agents Pralatrexate provide RdRP reduce Remdesivir Replication respiratory RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication screening procedure selected severe acute respiratory syndrome Coronavirus Spread therapeutic agents therapeutic target threat traditional methods treat Vaccine Viral viral replication Viral RNA viral RNA-dependent RNA polymerase Virtual screening virus worldwide crisis [DOI] 10.1371/journal.pcbi.1008489 PMC 바로가기 [Article Type] Research Article
Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine혈관 질환 또는 심혈관 위험 인자 및 COVID-19가 있는 환자의 관리를 위한 지침: VAS-European Independent Foundation in Angiology/Vascular Medicine의 입장 보고서Review Published on 2020-12-012022-09-12 Journal: Thrombosis and haemostasis [Category] MERS, SARS, 진단, [키워드] advanced age Antithrombotic Antiviral Arterial hypertension cardiovascular cardiovascular disease cardiovascular risk factor Care Community COVID-19 D-dimer Diabetes Mellitus disease disease symptoms eHealth technology Epidemic Factor Follow-up foundation Health high risk hospital discharge Hospitalization hospitalized patient hypercoagulability intermediate dose intravascular coagulation LMWH Male sex management manifested Medicine obesity oral anticoagulant paper Patient physical position progression receive risk risk factor severe COVID-19 Social distancing measure Thromboprophylaxis thrombosis Treatment treatment for COVID-19 unfractionated heparin Vascular vascular disease Venous Thromboembolism VTE VTE risk worsening [DOI] 10.1055/s-0040-1715798 PMC 바로가기 [Article Type] Review