Targeting TFH cells in human diseases and vaccination: rationale and practice Reviews Published on 2022-07-112022-10-05 Journal: Nature Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] allergens antibody antibody affinity Antigen approach Autoantigens B cell B cells boost CD4+ T cell Cell cytokine disease disease pathogenesis Efficacy facilitate human disease Humoral immunity Infection knowledge lymphomagenesis maturation mechanisms memory pathogen clearance pathogenic protective antibody response receptor regulate Regulation reservoirs response Support survival T cell targeting TCR therapy Vaccine [DOI] 10.1038/s41590-022-01253-8 [Article Type] Reviews
Mutations in SARS-CoV-2 are on the increase against the acquired immunity획득 면역에 대한 SARS-CoV-2의 돌연변이 증가 추세Article Published on 2022-07-112022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] accumulated mutation accumulated mutations acquired immunity administration animals approach booster vaccination booster vaccinations caused characterisation COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines effective Effectiveness Efficacy Evolution example Healthcare system humans Immunity infecting Infection lockdowns monovalent Mortality mRNA mutated Mutation New occur omicron Omicron variant other variants pandemic pathogenic patients PCA pressure provided question rate of infection resulting SARS-CoV-2 Spread strain Strains sustainability Taiwan Vaccine variant variants viral mutation Viral mutations [DOI] 10.1371/journal.pone.0271305 PMC 바로가기 [Article Type] Article
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases조직간 단세포 기질 아틀라스는 4가지 만성 염증성 질환에서 공유된 병리학적 섬유아세포 표현형을 식별합니다.Article Published on 2022-07-082022-09-11 Journal: Med (New York, N.Y.) [Category] 비임상, [키워드] Activation affected animal model animal models Arthritis atlas atopic dermatitis breath CCL19 chronic inflammatory disease chronic inflammatory diseases Clusters COL3A1 Critical CXCL10 disease Diseases donors exacerbated fibroblast fibroblasts Foundational research heterogeneity Hoffmann-La Roche identify immune individual inflamed tissue Inflammation Inflammatory bowel disease Inflammatory diseases integration interstitial Interstitial lung disease intestinal inflammation intestine joint lack lung Lung disease Lungs mapped organ systems Pathogenesis pathogenic pathway Pathways phenotype Phenotypes pro-inflammatory reveal rheumatoid arthritis Roche salivary gland salivary glands scRNA-seq single-cell Single-cell RNA sequencing Sjögren's syndrome SPARC stromal syndrome synovium therapeutic target ulcerative colitis [DOI] 10.1016/j.medj.2022.05.002 PMC 바로가기 [Article Type] Article
Acute Surge of Atypical Memory and Plasma B-Cell Subsets Driven by an Extrafollicular Response in Severe COVID-19심각한 COVID-19에서 난포 외 반응에 의해 구동되는 비정형 기억 및 혈장 B-세포 하위 집합의 급성 급증Article Published on 2022-07-082022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, 진단, [키워드] accumulating acute phase acute respiratory syndrome addition anti-SARS-CoV-2 antibody Antibody Response Atypical B cell B cells B-cell B-cell response BCR Cell Clinical severity coronavirus coronavirus disease COVID-19 COVID-19 patient Critical cytokine expression dataset disease course Disease progression disease severity driven by driver elevated Evidence extrafollicular response feature Features groups heterogeneous humoral Humoral immunity Inflammatory investigated mechanism memory B cell moderate naïve pandemic pathogenic pathway PC2 Peripheral blood plasma Plasma cell Plasma cells progression public health receptor response RNA robust Sequencing analysis severe COVID-19 severe COVID-19 patients severe disease severe patients severity single-cell subset Trajectory analysis transcriptional Vaccine with COVID-19 [DOI] 10.3389/fcimb.2022.909218 PMC 바로가기 [Article Type] Article
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics Reviews Published on 2022-07-072022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 신약개발, [키워드] Activation addition biological processes Cancer Cell cell metabolism cell proliferation cellular pathways change Chronic diseases disease Diseases downstream gene drugs Endoplasmic reticulum ERK expression Extracellular Factor Glycolysis Health hypoxia immune response implication Infection interact involved kinase mammalian cells mechanism Metastasis microbe Molecular oxygen NF-κB nuclear oxygen pathogenic pathway question Rapamycin reaction regulate respond responses Signaling Stress subsequent therapeutic therapeutic target tumorigenesis [DOI] 10.1038/s41392-022-01080-1 [Article Type] Reviews
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2SARS-CoV-2에 대한 인간 신경모세포종 세포의 전사적 풍경Article Published on 2022-07-062022-09-11 Journal: BMC neuroscience [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis applied approach Cell cells Central nervous system changes in chemokines contagious coronavirus Cytokines decrease differentially expressed gene Differentially expressed genes downregulated function functions Gene ontology host mRNA identify Infection Injury involved knowledge Kyoto mechanism mRNA mRNAs Neuroinflammation Neurological symptom Neurological symptoms NF-κB pathogenic Pathways Patient performed receptors reported RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly SK-N-SH cells. transcriptional profile transcriptional profiles transcriptomic Treatment upregulated [DOI] 10.1186/s12868-022-00728-6 PMC 바로가기 [Article Type] Article
Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19COVID-19의 구강 증상의 병원성 메커니즘 및 다중 오믹스 분석Review Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus Analysis bind caused clinical manifestation clinical manifestations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine Cytokines decrease droplets dysfunction dysregulation Factors Gustatory Host host cell host cells human ACE2 receptor immune immune cells immune dysregulation immune response Immunological analyses immunological analysis include infect Inflammation manifestation mount multi Multi-omics multiple organ failure Numerous oral oral cavity pathogen pathogenic phenotype reported respiratory distress respiratory infectious disease S protein Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 Spread structural protein structural proteins syndrome the S protein Trigger virus Xerostomia [DOI] 10.3389/fimmu.2022.879792 PMC 바로가기 [Article Type] Review
Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeuticsSARS-CoV-2 Omicron 변이체의 컴퓨터 분석에서 얻은 통찰력: 숙주-병원체 상호작용, 병원성 및 가능한 약물 치료법Article Published on 2022-07-012022-09-11 Journal: Immunity, Inflammation and Disease [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 Affect Alter Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity Characteristics Comparisons computational analysis correlated correlation correlations COVID-19 COVID-19 case COVID-19 cases docking docking result docking results drug Drug efficacy drugs drugs efficacy effective Effectiveness epidemiological evaluate evaluated Factor genomic sequence Host host-pathogen interaction human receptors insight Interaction lack less Lopinavir molecular docking molecular dynamics Molecular dynamics simulation Mutation mutational spectrum Nirmatrelvir NRP1 occurred omicron Omicron variant pathogenic pathogenicity Phylogenetic tree protease Protein Proteins raised Receptor-binding domain reconstructed Research response significant difference significant differences tested the receptor-binding domain the SARS-CoV-2 therapeutic approaches variant [DOI] 10.1002/iid3.639 PMC 바로가기 [Article Type] Article
Mendelian randomization study on the causal effects of COVID-19 on childhood intelligenceCOVID-19가 아동기 지능에 미치는 인과적 영향에 대한 멘델식 무작위 배정 연구Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, [키워드] 95% confidence interval Affect analyses Analysis anaplastic causal link change childhood childhood intelligence condition Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Decline declines demonstrated Effect European evaluate the effect Genetic genetic susceptibility genetic variants Genome-wide association study GWAS Hospitalized identify increased risk individual lung Lungs mendelian randomization metaplastic Odds ratio organ systems other organ other organs pathogenic resulting risk factor simple mode variant was used weighted median weighted mode [DOI] 10.1002/jmv.27736 PMC 바로가기 [Article Type] Article
Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2우한 균주에서 Omicron B.1.1.529까지의 SARS-CoV-2 수용체 결합 도메인은 인간 ACE2의 가변 구조에 대한 증가된 친화성을 특성으로 합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 receptor ACE2 receptors ACE2 variant ACE2 variants ACE2-RBD affinity analysed Analysis angiotensin Angiotensin-converting enzyme attribute B.1.1.529 binding binding domain binding efficiency binding energy Care caused changes in coding region complexes contributing to COVID-19 detect determine docking dynamic Dynamic simulation enzyme Genetic variant genetic variants global pandemic help highlight homology model Homology models Human human ACE2 human host Infectious disease Interaction isolates lead management molecular molecular dynamics nucleotide omicron pathogenic polymorphism Protein docking RBD RBD complex RBDs receptor Receptor binding domain Repository retrieved risk RMSD RMSF Safe SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus SARS‐CoV‐2 selected severity single nucleotide stability Structural variant structural variants Structure the RBD Total variant Variation was performed wildtype Wuhan Wuhan strain [DOI] 10.1016/j.jiph.2022.06.004 PMC 바로가기 [Article Type] Article