PD-L1 – Page 6 – Communicable Diseases Research

PD-L1 Dysregulation in COVID-19 Patients

Immunology

Published on 2021-06-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literature

Review

Published on 2021-05-312022-10-30
Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19,

Efficacy and Safety of Durvalumab Combined with Daratumumab in Daratumumab-Refractory Multiple Myeloma Patients

Article

Published on 2021-05-182024-09-02
Journal: Cancers [Category] 대상포진,

[키워드] CD38 Checkpoint inhibitor daratumumab durvalumab Immunotherapy Multiple myeloma PD-L1
[DOI] 10.3390/cancers13102452 PMC 바로가기 [Article Type] Article

Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers

COVID-19에 걸린 어린이의 혈액 호중구는 염증 및 항염증 마커를 모두 나타냅니다

Observational Study

Published on 2021-05-012022-08-31
Journal: EBioMedicine [Category] SARS, 바이오마커, 임상, 진단,

[키워드] Activation acute lung injury Adhesion Molecule adhesion molecules Adults analyzed Anti-inflammatory Asymptomatic Blood Blood samples Buenos Aire Buenos Aires CD11b CD64 CD66b Cell-adhesion molecules cell-free DNA children children with COVID-19 circulating neutrophil circulating neutrophils Concentration COVID-19 cytokine cytokine production Cytokines DNA ELISA expression Fcγ receptor flow cytometry fluorometry healthy children healthy controls HLA-DR IgG IgG antibodies IgG antibody immune response infiltration Inflammatory inhibitory receptor Inhibitory Receptors L-selectin low expression lower expression Lung function Lung injury marker Mild MIS-C Moderate COVID-19 NET NETs neutrophil Neutrophils no differences observational study PD-L1 pediatric pediatric COVID-19 phenotype plasma Plasma levels Prevent promotion quantified receptor respiratory respiratory symptoms SARS-CoV-2 Science serum severe COVID-19 severe respiratory symptom severe respiratory symptoms Spike protein supported syndrome technology the spike protein tissue university was performed were measured
[DOI] 10.1016/j.ebiom.2021.103357 PMC 바로가기 [Article Type] Observational Study

The pathogenic role of epithelial and endothelial cells in early-phase COVID-19 pneumonia: victims and partners in crime

Reviews

Published on 2021-04-212022-10-05
Journal: Modern pathology : an official journal of the Unit [Category] 바이오마커, 진단,

SARS-CoV-2 infection: The role of PD-1/PD-L1 and CTLA-4 axis

SARS-CoV-2 감염: PD-1/PD-L1 및 CTLA-4 축의 역할

Review

Published on 2021-04-012022-08-31
Journal: Life sciences [Category] MERS, SARS, 바이오마커,

[키워드] Acquired cascades causes cell-mediated immune China COVID-19 COVID-19 pandemic CTLA-4 CTLA4 cytokine Cytokines death decrease Defense diagnostic disease disorders dysfunction Effect Exhaustion expression extreme function functions immune immune response immune responses immune system immunogenicity increase in individuals with COVID-19 INF-γ Inflammatory response Inflammatory responses inhibitory Inhibitory immune checkpoint interferon interferon-γ lymphocyte lymphopenia Monocytes neutrophil Neutrophils outbreak PD-1 PD-L1 Peripheral blood reducing Regulation respiratory respiratory disorders SARS-CoV-2 secretion severity severity of COVID-19 Spread Symptom Symptoms T-cell T-cells Treatment treatment methods Viral viral infection viral infections virus Wuhan
[DOI] 10.1016/j.lfs.2021.119124 PMC 바로가기 [Article Type] Review

Proteomic blood profiling in mild, severe and critical COVID-19 patients

경증, 중증 및 중증 COVID-19 환자의 단백질체 혈액 프로파일링

Comparative Study

Published on 2021-03-182022-08-31
Journal: Scientific Reports [Category] 바이오마커, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome analyses ARDS Autoimmune Biomarker Blood blood protein blood proteins changes in CKAP4 Control COVID-19 COVID-19 cases COVID-19 disease COVID-19 positive patient Critical critical COVID-19 patient death Differential expression analysis disease Disease progression disease severity generate group identify IL-1ra IL6 in some individual individuals infected individuals Infection Inflammation LILRB4 Mild mild respiratory mild respiratory tract infection MONITOR multi-organ failure nine Olink PD-L1 potential therapeutic targets progression Protein proteomic proteomics respiratory respiratory distress respiratory tract infection SARS-CoV-2 pandemic severe pneumonia significantly syndrome the disease viral infection Visualization was performed
[DOI] 10.1038/s41598-021-85877-0 PMC 바로가기 [Article Type] Comparative Study

At the Crossroads: COVID-19 and Immune-Checkpoint Blockade for Cancer

갈림길에서: COVID-19와 암에 대한 면역 관문 차단

Article

Published on 2021-03-012022-09-11
Journal: Cancer immunology research [Category] 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral immune response antiviral immune responses blockade Cancer Characteristics clinical trials Complication complications of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination death decrease detrimental disease course Effect Evidence expression heterogeneity immune responses immunomodulatory effect immunomodulatory effects infections Inflammatory inflammatory complications Inflammatory response Inflammatory responses interferon interferon signaling leads Ligand MOST pathway Patient patients Patients with cancer PD-L1 PD1 PROTECT provided receiving receptor respiratory respiratory distress Respiratory distress syndrome RNA virus SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases Severe respiratory distress Support syndrome the disease therapy Viral viral infection virus infections worsening
[DOI] 10.1158/2326-6066.CIR-21-0008 PMC 바로가기 [Article Type] Article

Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients

중증 COVID-19 환자에서 자가포식 마커의 발현 감소 및 골수 유래 억제 세포의 확장은 불량한 T 세포 반응과 상관관계가 있습니다

Immunology

Published on 2021-02-222022-09-11
Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, 진단,

[키워드] accumulation Activation Affect Analysis analyzed antibody production autophagy B cell B cells CD4+ T cell Cell cellular cellular and humoral immune response coronavirus coronavirus disease Coronavirus Disease (COVID)-19 correlated correlation COVID-19 COVID-19 pathogenesis COVID-19 patient Critical Cytokines dendritic cell dendritic cells diagnostics disease dominant down-regulated driving dysregulated immune response ELISA expansion expression expressions flow-cytometry followed by functional healthy donor HLA-DR humoral immune response iCoS IFN-γ IL-10 IL-6 immune response immunological mechanism implication Inflammation interferon Laboratory parameters lymphocytopenia mild COVID-19 patient mild COVID-19 patients Monocytes multiorgan failure myeloid-derived suppressor cells NKT cells parameter PD-L1 Peripheral blood Pneumonia Poor quantitative PCR Regulatory regulatory lymphocytes respiratory response severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient severe patients significantly subset suppressor suppressor cells susceptible individuals T cell T cell response T cell subset T cells western blot
[DOI] 10.3389/fimmu.2021.614599 PMC 바로가기 [Article Type] Immunology

PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression

Review

Published on 2021-01-062024-09-02
Journal: Cancers [Category] 대상포진,

[키워드] adenosine CD38 microenvironment Multiple myeloma PD-1 PD-L1
[DOI] 10.3390/cancers13020164 PMC 바로가기 [Article Type] Review