Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
SOLVx therapeutics vaccine – Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2SOLVx 치료제 백신 - 돌연변이 균주 SARS-COV2에 대한 광범위한 감시 에피토프 전략을 사용하여 T 세포 면역 활성화Article Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha Analysis Anti-viral B cell B cells BALB/c mice biochemical biological samples cellular coronavirus cytokine levels Cytokine storm decrease Defense develop dose Effect Efficacy and safety elevated epitope eradication euthanized Evolution functional Genome HCoV HCoV-229E hematological humoral IFN-γ IL-10 IL-6 immune response Immunoglobulin Immunoglobulin G increase in interferon gamma Laboratory lung tissue Lungs mice mRNA mutable mutant mutant strain NK cell parameter PBMC PBMCs peptide peptides Prophylactic qPCR reduced SARS-COV2 mutant significantly SOLVx statistically significant suggested Surveillance T cell T-cell immunity therapeutic TNF-alpha TNF-α treated Treatment treatment group treatment groups Vaccine virus Virus evolution virus infectivity were assessed were used [DOI] 10.1016/j.biopha.2022.113212 PMC 바로가기 [Article Type] Article
T-cell responses to SARS-CoV-2 Omicron spike epitopes with mutations after the third booster dose of an inactivated vaccine비활성화 백신의 세 번째 추가 접종 후 돌연변이가 있는 SARS-CoV-2 오미크론 스파이크 에피토프에 대한 T 세포 반응Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Antibody Response Antibody responses booster dose booster vaccination conserved CoronaVac coronavirus dose elicited enhancement Epitopes escape estimate evaluated Impact Inactivated vaccine individual individuals Infection mononuclear cell mononuclear cells Mutation mutations omicron Omicron variant participant Participants PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells Protective respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly spike epitope Spike protein Spike proteins stimulate T-cell T-cell activation T-cell Response T-cell responses the SARS-CoV-2 the spike protein Vaccine Vaccines variant virus volunteers weakened were used [DOI] 10.1002/jmv.27814 PMC 바로가기 [Article Type] Article
Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS-CoV-2 Positive MothersObservational Study Published on 2022-08-012022-10-05 Journal: Molecular nutrition & food research [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome alcohols Aluminium amino acids Aminoacyl-tRNA Concentration conducted Conjugates control group coronavirus COVID-19 derivatives difference element elements Fatty acid Health Human human milk implication increase Infection information metabolite metabolomic metabolomics milk mother pathway peptides plasma positive profile provide purine quantification recorded reduce Research SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection signature significantly symptomatic and asymptomatic tyrosine unique with COVID-19 [DOI] 10.1002/mnfr.202200071 PMC 바로가기 [Article Type] Observational Study
Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과Article Published on 2022-07-292022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection sartans Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc [DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article
Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8 + T Cell Response in HLA-A Transgenic MiceSARS-CoV-2의 엑소좀 백신 로딩 T 세포 에피토프 펩티드는 HLA-A 형질전환 마우스에서 강력한 CD8 + T 세포 반응을 유도합니다Article Published on 2022-07-292022-09-11 Journal: International journal of nanomedicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjuvant Administered CD8 control group Coronavirus-2 current elicited epitope epitope peptide Ex vivo exosomal vaccine Exosome Exosomes fold followed by fraction frequencies Frequency fused generate HLA-A human leukocyte antigen human leukocyte antigen-A IFN-γ induce injected intracellular cytokine staining leukocyte mice Modification Neutralizing antibodies neutralizing antibody NMR nuclear nuclear magnetic resonance organ toxicity peak peptide peptides purification purified response robust SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly subcutaneously T cell T cell response T cell responses T cells the SARS-CoV-2 virus the severe acute respiratory syndrome coronavirus-2. transgenic mice transmission electron microscopy Vaccine vaccine group western blotting wild-type [DOI] 10.2147/IJN.S367494 PMC 바로가기 [Article Type] Article
Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variantsSARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan [DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article
A ricin-based peptide BRIP from Hordeum vulgare inhibits M pro of SARS-CoV-2Hordeum vulgare의 리신 기반 펩타이드 BRIP는 SARS-CoV-2의 M pro를 억제합니다Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] barley binding binding free energy binding site caused complex component components contributed COVID-19 cytotoxicity domains electrostatic free energy Hordeum identify in vitro inhibit inhibitor inhibitors inhibitory Interaction investigated M pro MD simulations molecular molecular docking molecular dynamics pandemic parameter peptide peptides Research ricin SARS-CoV-2 SARS-CoV-2 main protease stability suggested therapeutic potential thermodynamic Trajectories trajectory Van Van der Waals virus [DOI] 10.1038/s41598-022-15977-y PMC 바로가기 [Article Type] Article
Longitudinal monitoring of SARS-CoV-2 spike protein-specific antibody responses in Lower AustriaLower Austria에서 SARS-CoV-2 스파이크 단백질 특이적 항체 반응의 종단적 모니터링Article Published on 2022-07-272022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activities activity Analysis analyzed antibody Antibody Response Community comprehensive view correlated COVID-19 eight hotspot IgA IgA level IgG IgG levels immune responses Immunoglobulin immunoglobulin A Infection infections longitudinal Lower participant Participants peptides positive reduction in remained reported SARS-CoV-2 SARS-CoV-2 spike significantly T cell the receptor-binding domain the spike protein Wachau [DOI] 10.1371/journal.pone.0271382 PMC 바로가기 [Article Type] Article
Transient and durable T cell reactivity after COVID-19COVID-19 이후 일시적이고 지속적인 T 세포 반응성Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Antigen antigens Cell convalescent patient Convalescent patients coronavirus correlated COVID-19 cytokine Cytokines determine Ex vivo followed by IL-12 IL-13 IL-17 IL-2 Infection interferon interferon-γ interleukin long-lasting Longevity median N-terminal nucleocapsid protein Patient peptide peptides Polarity Protein reactivity remained respiratory retrieved SARS-CoV-2 severe acute respiratory syndrome Coronavirus stimulated synchronous T cell T cell cytokines T cell memory T helper T helper cells Transient triggered whole blood sample [DOI] 10.1073/pnas.2203659119 PMC 바로가기 [Article Type] Article