Immunological Interfaces: The COVID-19 Pandemic and DepressionNeurology Published on 2021-04-232022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] addition affecting Care contribute coronavirus disease COVID-19 Critical Cytokine storm Cytokines Depression depressive described detrimental effort Health immune Immunity immunological increased risk increasingly International mental health microglia outcome pandemic Perturbation pro-inflammatory state Quality of life SARS- CoV-2 SARS-COV-2 infection Spread structures underlie [DOI] 10.3389/fneur.2021.657004 PMC 바로가기 [Article Type] Neurology
Inflammasome Activation-Induced Hypercoagulopathy: Impact on Cardiovascular Dysfunction Triggered in COVID-19 PatientsReview Published on 2021-04-162022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] Activation activation of inflammasome addressed angiotensin-converting enzyme 2 Arrhythmias cardiovascular cardiovascular complications cardiovascular condition cardiovascular disorder cellular response contribute Coronavirus disease 2019 COVID-19 COVID-19 complications COVID-19 patient COVID-19 patients Cytokine storm Defense dendritic cells described downstream endothelial cells Host Hypercoagulopathy hyperinflammation Impact Infectious disease Inflammasome inflammasome activation Inflammation Inflammatory response Interaction less macrophages mechanism modulation myocardial injury myocarditis NLRP3 NLRP3 inflammasome Pathogenesis Perturbation Pneumocytes poor prognosis positive reduction SARS-CoV-2 SARS-COV-2 infection shown signaling pathways significantly suppress target cell tissue triggered Venous Thromboembolism viral infections [DOI] 10.3390/cells10040916 PMC 바로가기 [Article Type] Review
Top-Down and Bottom-Up Proteomics Methods to Study RNA Virus BiologyReview Published on 2021-04-132022-10-28 Journal: Viruses [Category] COVID-19, [키워드] (+)RNA viruses affinity purification liquid chromatography coupled to mass spectrometry (AP-LC-MS/MS) alphaviruses Antiviral approach Biology bottom-up proteomics cellular complex complexes Coronaviruses Critical Effect flaviviruses function functions high mortality Host host responses human disease identify implication information macromolecular mass spectrometry morbidity Pathogenesis Perturbation post-translational modifications Protein protein complexes Replication RNA RNA virus screening method Sequencing Streamline structural proteomics targets top-down proteomics translational unique Viral protein virus [DOI] 10.3390/v13040668 PMC 바로가기 [Article Type] Review
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV Research Published on 2021-04-122022-10-05 Journal: Nature [Category] SARS, 신약개발, 치료제, [키워드] Antiviral effect autophagy both viruses cellular interaction Coronaviruses COVID-19 dataset drug dysregulated fibrosis heterogeneity highlight Host Host-directed therapies hotspot human cell infection with SARS-CoV-2 inhibitor integration Interaction kinase knowledge matrix metalloprotease molecular function molecular mechanism ORF3 ORF8 pathogenic pathway Perturbation phosphoproteome proteome proteomics reveal SARS-CoV SARS-CoV-2 Spread TGF-β These data tissue to define Transcriptome Viral protein virus virus–host interaction [DOI] 10.1038/s41586-021-03493-4 [Article Type] Research
Semi-supervised learning for an improved diagnosis of COVID-19 in CT imagesCT 이미지에서 향상된 COVID-19 진단을 위한 준지도 학습Research Article Published on 2021-04-012022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] Accuracy Chain Reaction coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis dataset datasets Diagnosis diagnosis of COVID-19 diagnostic Diagnostic accuracy evaluate experiment facilitate IMPROVE labeling management Non-COVID-19 Patient care Perturbation perturbations Pneumonia polymerase chain polymerase chain reaction Positive predictive value PPV Predictive value reliability robustness RT-PCR semi-supervised learning sensitivity specificity Spread suggested supervised learning unsupervised learning utility [DOI] 10.1371/journal.pone.0249450 PMC 바로가기 [Article Type] Research Article
Human coronaviruses in idiopathic Parkinson’s disease: Implications of SARS-CoV-2’s modulation of the host’s transcriptome특발성 파킨슨병의 인간 코로나바이러스: SARS-CoV-2의 숙주 전사체 조절의 의미Article Published on 2021-04-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] among others analyses Analysis comparison Control coronavirus determine disease Diseases Effect enriched pathways enrichment analyses enrichment analysis false discovery rate FDR Gene Expression Gene ontology Gene Set Enrichment Analyses GSEA head Head-to-head comparisons Host Human human coronavirus human coronaviruses Huntington's disease immune response indicated modulation mononuclear cell motor nucleus mRNA NAFLD neurodegeneration neurodegenerative Neuroinvasive nigra not limited Ontology overlap overlapping parasitism parkinson s disease Parkinson's Disease Pathogenesis pathway Patient PBMC performed Peripheral blood Perturbation retrieved SARS-CoV-2 SARS-COV-2 infection scrutiny statistically significant substantia substantia nigra Surveillance tissue tissues Transcriptome transcriptomic Whole blood [DOI] 10.1016/j.meegid.2021.104733 PMC 바로가기 [Article Type] Article
A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 InfectionSARS-CoV-2 감염으로 인한 세포 교란의 네트워크 표현을 위한 리소스Article Published on 2021-03-222022-09-10 Journal: Genes [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect approach approaches can be used causal network causal relationships caused cell physiology cellular cellular pathway cellular phenotype cellular phenotypes contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathology drug effective effort enrichment analysis etiology framework functional Health high-throughput experiments hypothese information inhibitor inhibitors lack list majority molecular mechanism molecular mechanisms network offer pandemic pathology Pathways Perturbation produced Protein Proteins reported representation resource respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling signaling pathways subset the coronavirus disease 2019 (COVID-19) Therapeutic strategies Treatment Viral viral infection [DOI] 10.3390/genes12030450 PMC 바로가기 [Article Type] Article
Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection네트워크 분석 및 전사체 프로파일링으로 SARS-CoV-2 감염에서 자가포식 및 미토콘드리아 기능 장애 식별Genetics Published on 2021-03-162022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] A549 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral antiviral signaling autophagic autophagic flux autophagy autophagy genes biological processe biological processes Calu3 chemokines co-expression network analysis contributing to coronavirus COVID-19 Critical downregulated downregulating drugs targeting expression of gene expression profile expression profiles GSK3B help host cell host cells IAV infected cell infected cells Infection infections Inflammation Inflammatory Influenza influenza A influenza A virus interferon signaling interferon-stimulated genes Intervention involved lung cell line lung cell lines lysosome acidification MERS MERS-CoV mitochondrial mitochondrial complex I mitochondrial fission Mitochondrial function mitochondrial ribosomal mTOR mTOR expression nasopharyngeal sample network Perturbation perturbations Profiling respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SNAP29 tested transcriptional response transcriptomics Tripartite Motif upregulating upregulation validation study Viral viral pathogenesis viral replication [DOI] 10.3389/fgene.2021.599261 PMC 바로가기 [Article Type] Genetics
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactionsSARS-CoV-2 감염의 Shotgun transcriptome, spatial omics 및 등온 프로파일링은 독특한 숙주 반응, 바이러스 다양화 및 약물 상호 작용을 나타냅니다.Article Published on 2021-03-122022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 임상, 진단, 치료기술, 치료제, [키워드] ACE ACE2 expression acute respiratory syndrome addition aldosterone angiotensin applied Autopsy Biomarker Biomarkers caused clade clinical sample clinical samples Computational biology and bioinformatics coronavirus coronavirus 2 COVID-19 disease COVID-19 pandemic COVID-19 patient detect develop diagnostic disease course Diseases drug interaction drugs Evolution feature Gene Expression Genetic help hematological highlight Host host response host responses identify Infection inhibitor interferon isothermal LAMP less loci Lungs Macrophage microbial molecular neutrophil neutrophil infiltration New York City nine outbreak outcomes Pathways Patient patient records Perturbation platform protective effect public health respiratory reveal SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 shotgun significant enrichment specimen Swab tissue tissues Transcriptome transcriptomic data Treatment strategies unique Viral virus yielding [DOI] 10.1038/s41467-021-21361-7 PMC 바로가기 [Article Type] Article
Targeting MMP-Regulation of Inflammation to Increase Metabolic Tolerance to COVID-19 Pathologies: A HypothesisCOVID-19 병리에 대한 대사 내성을 증가시키기 위한 염증의 MMP 조절 목표: 가설Essay Published on 2021-03-062022-09-01 Journal: Biomolecules [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 AMPK Combination Coronavirus-2 COVID-19 damage develop elicit elicited energy metabolism Evidence focus Host human host hyper-inflammation immunopathology increase individual Infection Inflammation Interaction lung matrix metalloproteinase matrix metalloproteinases mechanism metabolic metabolic tolerance metabolism mild symptoms MMP Mounting multiorgan failure organ organs pathogen Pathogens Pathologies pathology Perturbation Pneumonia regulated respiratory respiratory distress Respiratory failure SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spectrum syndrome systemic inflammation target target organ target organs targeting Therapeutic approach therapeutic approaches therapeutic target therapeutic targets tissue damage Viral while [DOI] 10.3390/biom11030390 PMC 바로가기 [Article Type] Essay