Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats임신한 쥐에서 항바이러스성 렘데시비르와 주요 대사산물인 GS-441524의 생체변환 및 태반 전이Article Published on 2022-07-012022-09-11 Journal: EBioMedicine [Category] 치료제, [키워드] amniotic Amniotic fluid Anti-viral approved AUC Biotransformation Blood Blood-placental barrier C max coronavirus disease Coronavirus disease 2019 COVID-19 cross during pregnancy evaluated fetus GS-441524 Hypothesis Liquid chromatography mass spectrometry maternal blood metabolite Microdialysis MONITOR mother multisite nucleoside parameter pharmacokinetic pharmacokinetics Placenta placental barrier predominant Pregnancy pregnant RATs Remdesivir Science shown Taiwan Tandem mass spectrometry technology tissues transfer treat Treatment UHPLC was used while [DOI] 10.1016/j.ebiom.2022.104095 PMC 바로가기 [Article Type] Article
Placenta as a site of HEV replication and inflammatory cytokines modulating the immunopathogenesis of HEV in pregnant womenArticle Published on 2022-07-012023-06-12 Journal: Journal of medical virology [Category] E형 간염, [키워드] Cytokines hepatitis E virus HEV antigen immunohistochemistry Placenta Pregnancy [DOI] 10.1002/jmv.27699
SARS-CoV-2 RNA detection in Formalin-Fixed Paraffin-Embedded (FFPE) tissue by droplet digital PCR (ddPCR)물방울 디지털 PCR(ddPCR)에 의한 포르말린 고정 파라핀 포매(FFPE) 조직에서 SARS-CoV-2 RNA 검출Article Published on 2022-07-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] amplified Atypical Bio-rad cause clinical utility clinically COVID-19 digital PCR droplet droplet digital PCR extraction fetal FFPE formalin formalin-fixed paraffin-embedded highest Infection limit of detection liver liver transplant liver transplant rejection material paraffin Placenta Placental viral infection positive positive sample Pregnancy qualitative test quantified rejection reported Respiratory disease reverse transcription RNA virus RPP30 SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA detection sequence specimen specimens tested tissue Tissue-based viral detection total RNA transplant rejection Viral detection Viral detection in FFPE. viral infection [DOI] 10.1016/j.cca.2022.05.007 PMC 바로가기 [Article Type] Article
Placental pathology from COVID-19-recovered (nonacute) patientsArticle Published on 2022-07-012023-07-08 Journal: Human pathology [Category] COVID19(2023년), [키워드] COVID-19 fetal vascular malperfusion Maternal vascular malperfusion Placenta SARSp-CoV-2. [DOI] 10.1016/j.humpath.2022.04.005 PMC 바로가기
Monocytes and macrophages in pregnancy: The good, the bad, and the uglyReview Published on 2022-07-012023-07-08 Journal: Immunological reviews [Category] COVID19(2023년), [키워드] Bacterial monocytes/macrophages Placenta Pregnancy reproductive Immunology Viral [DOI] 10.1111/imr.13080 [Article Type] Review
Third trimester messenger RNA COVID-19 booster vaccination upsurge maternal and neonatal SARS-CoV-2 immunoglobulin G antibody levels at birth임신 3기 전령 RNA COVID-19 부스터 백신 접종 시 산모 및 신생아 SARS-CoV-2 면역글로불린 G 항체 수준 급증Article Published on 2022-07-012022-09-12 Journal: European journal of obstetrics, gynecology, and re [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval Administered administration Admission analyzed antibodies antibody Antibody titers Blood BNT162b2 BNT162b2 mRNA body mass index booster booster dose booster vaccination Booster vaccine Characteristics contrary correlation COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine dropped evaluate IgG Immunoglobulin increase in Messenger RNA mRNA multivariable analysis Neonatal Newborn pandemic Pfizer/BioNTech Placenta positive correlation Pregnancy pregnant women prospective cohort study reflected response SARS-CoV-2 SARS-CoV-2 IgG antibody Side effect Standard deviation Support systemic side effect Third trimester. umbilical vaccination Vaccine vaccine dose were measured women [DOI] 10.1016/j.ejogrb.2022.05.029 PMC 바로가기 [Article Type] Article
Clinical-pathological features in placentas of pregnancies with SARS-CoV-2 infection and adverse outcome: case series with and without congenital transmissionObservational Study Published on 2022-07-012022-10-05 Journal: BJOG : an international journal of obstetrics and [Category] COVID19(2023년), SARS, 임상, [키워드] APGAR score Care case sery cells chronic histiocytic intervillositis clinical Clinical outcome coronavirus correlated COVID-19 COVID-19 maternal-fetal transmission COVID-19 symptom Diagnosis died distress dysfunction endothelial Endothelium feature fetal fetal distress hypoxia Infant Infants infected with SARS-CoV-2 macrophages massive Maternal maternal floor infarction Necrosis nine outcome pathology Placenta placental placental endothelial cells Placental infection placental pathology Pregnancy pregnant women presenting reduced fetal movement reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 placental infection seeking Seven SIGN Stillbirth subsequent Transmission umbilical cord blood vertical SARS-CoV-2 transmission villous macrophages. [DOI] 10.1111/1471-0528.17132 PMC 바로가기 [Article Type] Observational Study
COVID-19 & differential effects in twins: Insights from Placenta PathologyCOVID-19 및 쌍둥이의 차별적 영향: 태반 병리학의 통찰력Case Reports Published on 2022-06-242022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 age COVID-19 Effect expression female fetal gestational age identify Infection insight Interaction interactions male Necrosis outcomes Placenta Placentas Pregnancy Premature premature delivery receptor SARS-CoV-2 Sex survival Task Force tissue twin twin pregnancy unique were used [DOI] 10.1016/j.placenta.2022.05.014 PMC 바로가기 [Article Type] Case Reports
Pulmonary and Systemic Pathology in COVID-19Article Published on 2022-06-242022-11-15 Journal: Deutsches Ärzteblatt international [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory distress affected Alter Analysis Angiogenesis ARDS arise Autopsy Brain cardiovascular system Central nervous system change clinical picture concerning contribute COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Endothelium Evidence gastrointestinal tract interstitial invagination Ischemia kidneys liver Lungs mechanisms molecular organ organ damage outbreak pandemic pathophysiology Placenta pulmonary Regulatory retrieved risk factor selective severe cases syndrome systemic thrombosis tissue various tissue vessel [DOI] 10.3238/arztebl.m2022.0231 PMC 바로가기
SARS-CoV-2, Placental Histopathology, Gravity of Infection and Immunopathology: Is There an Association?Article Published on 2022-06-182023-07-09 Journal: Viruses [Category] COVID19(2023년), [키워드] ACE-2 CD4 CD8 immunohistochemistry immunopathology Placenta RT-PCR SARS-CoV-2 [DOI] 10.3390/v14061330 PMC 바로가기