Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular DysfunctionReview Published on 2020-10-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Activation arteries Atherosclerosis atherosclerotic plaque atherosclerotic plaques Care caused Complete coronary blood flow disease dysfunction Health heart individual ion channels Ischemic ischemic heart disease mechanism Microcirculation Myocardial infarction observation paradigm pathophysiological pathophysiological mechanism pathophysiology plaque resource [DOI] 10.3390/ijms21218118 PMC 바로가기 [Article Type] Review
Virus-induced p38 MAPK activation facilitates viral infection바이러스 유도 p38 MAPK 활성화로 바이러스 감염 촉진Research Paper Published on 2020-10-302022-09-10 Journal: Theranostics [Category] MERS, SARS, 치료법, [키워드] activate activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral assays binding Cas9 clinical samples confocal microscopy core protein coronavirus correlation CRISPR cultured cell cultured cells determine expected facilitate facilitated Fever GST HCV hepatitis C hepatitis C virus hepatocyte hepatocytes herpes simplex herpes simplex virus herpes simplex virus type 1 HSV-1 immunohistochemistry in viral Infection inhibited Interaction investigated MAP3K7 MAPK mass spectrometry mechanism mitogen-activated protein kinase MOST N-terminal oligomerization P38 activation pathway Patient PCR peptide pharmacological phosphorylated Phosphorylation plaque plaque assays promoted Protein protein kinase qRT-PCR Quantitative quantitative real time PCR rationale real time real time PCR Replication respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus SFTSV signaling pathway siRNA suppressed syndrome TAB1 TGF-β thrombocytopenia tissue triggering Viral viral infection viral infections viral replication virus were used western blotting [DOI] 10.7150/thno.50992 PMC 바로가기 [Article Type] Research Paper
Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular CondensatesArticle Published on 2020-10-182022-10-28 Journal: Viruses [Category] COVID-19, [키워드] aerosol droplet aerosol droplets aggregate aggregates Analysis antiviral responses benefit bioinformatics biomolecular condensate cellular condensate conserved contribute copper deregulation disease disease-causing Diseases domain Dynamics eliminated feature function functions Gene Expression genomic RNA hallmark homeostasis Infection insoluble interfere Ion liquid-liquid phase separation mechanism membraneless organelle Meta-analysis modify modulate morphology neurodegenerative Neurodegenerative disease Neurological disease Neurological diseases nucleocapsid nucleocapsid protein Numerous organelle ortholog pan-virus persistence phase physiological plaque prion-like disordered protein domain promote Protein protein domain RBD RBDs Regulation Replication representing required Research responsible retrovirus RNA-binding domain separation stress granule therapeutic viral genomic RNA Viral protein virus virus infection vRNA while Zinc zinc finger motif [DOI] 10.3390/v12101179 PMC 바로가기 [Article Type] Article
The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, ChinaArticle Published on 2020-04-302022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, SARS, [키워드] accompanied age analyzed Asymptomatic carriers asymptomatic patient Attention can be used Characteristics characteristics of patient China clinical Clinical features clinical manifestation clinical symptom Clinical symptoms Cluster collected coronavirus coronavirus 2 cough COVID-19 COVID-19 patient COVID-19 patients D-dimer described diagnose Diagnosis diarrhea disease eight elevated Epidemic epidemiological erythrocyte sedimentation rate female Fever ground-glass opacity Hunan implication Infection laboratory result Laboratory results LDH lymphocyte male mild cases mild patient Most patient nucleic acid nucleic acid test objective occurred outbreak Patient patients patients with COVID-19 Pharyngeal swab plaque positive Protein reduction in regions respiratory Result SARS-CoV-2 SARS-COV-2 infection significantly Spread stools Symptom Tear the median throat swab viral infection were infected White blood cell Whole blood Wuhan [DOI] 10.1016/j.jcv.2020.104397 PMC 바로가기 [Article Type] Article
Shigella Pathogenesis Modeling with Tissue Culture Assaysarticle Published on 2018-08-312024-09-01 Journal: Curr Protoc Microbiol [Category] 세균성이질, [키워드] enteroid Invasion plaque Shigella tissue culture [Article Type] article
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Affect Analysis annotations approach arterial plaque macrophage arteries Atherosclerosis binding site canonical Cell cell motility cell type chromatin circulating condition control group demonstrated detect differentially expressed drug treatments eight element enrichment epigenomic eQTL Evidence expression foam cell functional Gene Expression humans identify in vitro in vivo increase Inflammation inflammatory disease inflammatory state innate immune system less Lipoproteins lowering Macrophage Macrophage response macrophage responses macrophages mice Migration molecular mouse model network overlap plaque plaque macrophage plaque macrophage response plaque macrophage responses plaque macrophages plaque regression plaques plasma lipoprotein plasma lipoproteins power promoter promoters reducing regressing plaque regressing plaques Regression Regression model regression models regulatory region response reversed risk significantly SNPs statins statistically Stimulation Systems biology TCF/LEF therapeutic target transcription factor transcription factors transcriptional change Transcriptome upregulated upregulated gene upregulated genes upstream validation study while Wnt Wnt signaling Wnt signaling pathway β-catenin [DOI] 10.1371/journal.pgen.1004828 PMC 바로가기 [Article Type] Research Article
CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent InfectionResearch Article Published on 2014-11-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence antibody Asia assays bat Betacoronavirus Cell cell line cell lines cellular dose-dependent manner downregulation downstream expression Factors fatal disease functional Host Human identify immunofluorescence Infection inhibited mammals MERS-CoV Middle East persistent plaque receptor reservoir respiratory respiratory syndrome coronavirus susceptibility susceptible syndrome transmission electron microscopy [DOI] 10.1371/journal.pone.0112060 PMC 바로가기 [Article Type] Research Article
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach새로운 MMP12 유전자좌는 게놈 전체 발병 연령 정보 접근 방식을 사용하여 대동맥 죽상경화성 뇌졸중과 연관됩니다Research Article Published on 2014-07-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (atherosclerosis) affected affection age analyses Analysis approach arteries Artery association associations Atherosclerosis atherosclerotic carotid carotid artery chromosome chromosome 11 Conditioning controls covariate demonstrated detect disease disease risk European evaluate Evidence evidence of examined explain Fold change fraction genetic association genetic associations genetic component Genetic predisposition Genetic variant Genome-wide association studies global healthcare GWAS heterogeneity identify IMPROVE increased risk independent information Informed investigated ischaemic stroke large artery lead loci locus Meta-analysis MMP12 mRNA expression novel novel association novel associations overexpressed performed phenotype phenotypic plaque plaques power prevalence rate prevalence rates Regression regression analysis Replication risk significantly small vessel SNP association SNP associations stroke subtype Subtypes the disease variant variants was performed [DOI] 10.1371/journal.pgen.1004469 PMC 바로가기 [Article Type] Research Article
Peptides Corresponding to the Predicted Heptad Repeat 2 Domain of the Feline Coronavirus Spike Protein Are Potent Inhibitors of Viral InfectionResearch Article Published on 2013-12-032022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] addition Anti-viral Antiviral effect antiviral efficacy caused clinically Concentration coronavirus Coronavirus infection cytotoxicity demonstrated effective Efficacy evaluated exhibiting Feline infectious peritonitis FIVE heptad repeat IFN-α immune-mediated disease Infection inhibit inhibited Interferon-α MTT overlapping peptide performed plaque potent reduction Repeat Result selected sequence spike synergistic the spike protein therapy viral replication [DOI] 10.1371/journal.pone.0082081 PMC 바로가기 [Article Type] Research Article
Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based RecombinationResearch Article Published on 2012-03-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] absence acute respiratory syndrome Analysis antiviral drug approach caused cDNA Cell characterization classical cloned Comparative analysis culture supernatant dendritic cell effective expressing facilitate Gene Expression generate Genome HCoV-229E Health Heterologous human coronavirus 229E in vitro transcription infectious Infectious virus led to less original form outbreak parental pathogenic plaque produced public health measures released Renilla luciferase Renilla luciferase gene Replication replication kinetics reporter reverse genetic system risk RNA transcript RNA transcripts robust SARS-CoV SARS-CoV Frankfurt-1 SARS-related coronavirus severe transfection Vaccines vaccinia vaccinia virus vectors virulent virus zoonotic disease [DOI] 10.1371/journal.pone.0032857 PMC 바로가기 [Article Type] Research Article