Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19COVID-19에 대한 혁신적인 백신 및 치료 전략을 위해 강글리오사이드에 대한 코로나바이러스 결합 활용Article Published on 2021-01-292022-09-12 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, [키워드] ACE-2 receptor analyzed antibody Antibody binding Azithromycin bind binding binding domain binding site blocked cellular convalescent coronavirus COVID-19 Critical epitope explain flat ganglioside Hydroxychloroquine identity Infection Interaction isolate Lipid Lipid raft N-terminal domain neutralizing antibody NTD offer overlap patients plasma membrane RBD Receptor binding domain Respiratory disease S protein S trimer SARS-CoV-2 SARS-CoV-2 neutralization supported the S protein therapeutic therapeutic strategy These data unique Vaccine virus Virus spike [DOI] 10.1016/j.bbrc.2020.10.015 PMC 바로가기 [Article Type] Article
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다Research Article Published on 2021-01-192022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ablated activate activated activating antiviral activities antiviral activity Autoimmune disorders block cathepsin L Cathepsins cause Cell cell entry cell surface cell-culture studies cell-culture systems Chloroquine cleave clinically Combination combinations coronavirus COVID-19 COVID-19 patient dependent on Efficacy endocytosis Endosomal acidification endosomal protease explain functional furin furin cleavage site furin-cleavage site global public health human clinical trial human clinical trials Hydroxychloroquine identify in vivo Infection inhibit inhibit SARS-CoV-2 interfere introduced lack malaria membrane fusion observé pathogenic coronavirus pathway plasma plasma membrane Prevent protease TMPRSS2 Protein Proteins proteolytic activity Receptor binding reversed S protein S proteins SARS Coronavirus SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike shown target cell target cells tested the cell the SARS-CoV-2 these compounds TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 pathway treat treated treatment for COVID-19 utility Viral viral entry viral infection [DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosisResearch Article Published on 2021-01-192022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome block Cell CHC, clathrin heavy chain clathrin Clathrin-mediated endocytosis coronavirus COVID-19 CQ, Chloroquine Critical cytosol dynamin endocytic mechanism endocytosis infect Infection infection mechanism infection process knockdown lentivirus MERS-CoV, Middle-East respiratory syndrome coronavirus occur other coronaviruses plasma membrane pseudotyped purified reduce required SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus spike glycoprotein Tf, transferrin TfR, Tf receptor transfer viral entry viral infectivity Viral RNA virus entry virus infectivity [DOI] 10.1016/j.jbc.2021.100306 PMC 바로가기 [Article Type] Research Article
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection Research Published on 2021-01-112022-10-05 Journal: Nature Genetics [Category] 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 expression airway epithelial cell airway epithelium amino acids Cell contribute Critical enzyme expressed FIVE high-affinity binding Host host susceptibility identify in viral Infection interferon interferon stimulation isoform lack plasma membrane Protein respiratory epithelia respiratory virus resulting rhinovirus RNA RNA genome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike the SARS-CoV-2 thought transcript Trigger unlikely upregulated viral infection [DOI] 10.1038/s41588-020-00759-x [Article Type] Research
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage siteResearch Article Published on 2021-01-042022-10-31 Journal: eLife [Category] COVID-19, [키워드] acute respiratory syndrome airway Airway organoids bind blocking Calu-3 cell Cathepsins Cell cell lines cleavage coronavirus COVID-19 endosomal entry facilitated faster host proteases human airway in vivo increase inhibited MBCs multibasic cleavage site Organoid plasma membrane protease receptor Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 entry Serine serine protease serine proteases Syncytia the SARS-CoV-2 the spike protein viral entry virus [DOI] 10.7554/eLife.64508 PMC 바로가기 [Article Type] Research Article
Might proton pump or sodium‐hydrogen exchanger inhibitors be of value to ameliorate SARs‐CoV‐2 pathophysiology?Review Article Published on 2020-12-252022-10-28 Journal: Physiological Reports [Category] COVID-19, [키워드] administration animal model approach benefit biogenesis bronchitis candidate cathepsin Cell cell entry cleavage complex compounds contributed CoV COVID‐19 COVID‐19 Cytokine release syndrome disease pathogenesis Disease progression disrupt disrupting drug Efficacy endocytic endosomal complexes required for transport endosomal pH entry pathway envelope exacerbate Exosome Exosomes extracellular vesicle Extracellular vesicles glycosylation Golgi Infection inhibit inhibiting inhibitor involved mechanism membrane mice Microvesicles multivesicular body occur Pathogenesis plasma membrane PPI promote Pulmonary edema pulmonary epithelial cell reported serine protease TMPRSS2 Spike protein suggested therapeutic Transport Vesicle viral endocytosis viroporin viruses [DOI] 10.14814/phy2.14649 PMC 바로가기 [Article Type] Review Article
Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19Discussion Published on 2020-12-012022-10-05 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 신약개발, [키워드] 3D structure ACE2 ACE2-B0AT1 addressed adjuvant Amino acid angiotensin-converting enzyme 2 bind caused cells Course COVID-19 COVID-19 disease docked drug Drug discovery effective global pandemic health emergency indications Infection Interaction International involved membrane protein nimesulide Occurrence physical plasma membrane potent receptor repurposing responsible SARS-CoV-2 SARS-CoV-2 biology Scientific community shown SLC6A19 Symptoms target cells tested the SARS-CoV-2 Transport treat Treatment Trial Vaccine viral entry Viral protein virus WHO World Health Organization [DOI] 10.1177/2472555220934421 [Article Type] Discussion
Shigella flexneri Disruption of Cellular Tension Promotes Intercellular Spread시겔라 플렉스네리 세포 긴장 파괴가 세포 간 전파를 촉진한다Article Published on 2020-11-242024-08-22 Journal: Cell Reports [Category] 세균성이질, [키워드] cell-to-cell spread intercellular spread intracellular pathogens IpaC plasma membrane Shigella flexneri type 3 secretion system β-catenin
Possible protective role of 17β-estradiol against COVID-19Article Published on 2020-11-082022-10-30 Journal: Journal of allergy and infectious diseases [Category] COVID-19, [키워드] 17β-estradiol ACE2 acute respiratory distress all age groups angiotensin-converting enzyme 2 appear ARDS binding cause cells coronavirus disease COVID-19 develop down-regulate fatality infect cell Medical conditions men Older Patient plasma membrane priming protease Protective protective role Protein protein expression RAAS SARS-CoV-2 SARS-CoV-2 spike protein serine 2 severe complication Sex difference syndrome therapeutic TMPRSS2 transmembrane virus WHO women World Health Organization worldwide pandemic [DOI] 10.46439/allergy.1.010 PMC 바로가기 [Article Type] Article
Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterolArticle Published on 2020-10-052022-10-06 Journal: The EMBO Journal [Category] MERS, SARS, 진단, [키워드] COVID‐19 treatment activating Activation Antiviral antiviral therapy Betacoronavirus caused cholesterol cholesterol 25‐hydroxylase concentrations convert Coronavirus disease 2019 COVID deplete depleting effective enzyme Epidemics globe Host Host immune response human lung organoids Infection Infectious virus inhibit Innate immunity ISG lung epithelial cell mechanism membrane Membrane & Intracellular Transport membrane fusion MERS Microbiology, Virology & Host Pathogen Interaction Middle East other coronavirus outbreak pathogenic coronaviruses patients plasma membrane provide related virus respiratory syndrome coronavirus restriction factor of coronaviruses Spread subsequent suppress therapeutic Toxicity USA Vaccine viral disease viral entry viral fusion viral membrane viral pathogenesis [DOI] 10.15252/embj.2020106057 PMC 바로가기 [Article Type] Article