A combined strategy to detect plasma samples reliably with high anti-SARS-CoV-2 neutralizing antibody titers in routine laboratories일상적인 실험실에서 높은 항-SARS-CoV-2 중화 항체 역가로 혈장 샘플을 안정적으로 검출하기 위한 결합된 전략Article Published on 2021-11-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 IgG approach BSL-2 Cell Convalescent plasma therapy COVID-19 criterion detect detection Detection of anti-SARS-CoV-2 neutralizing antibodies Effectiveness example feasible Humoral immunity Laboratory long-lasting NAb NAb assay NAb assays NAb titer NAb titers NAbs neutralization test Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer plasma plasma sample plasma samples reduce risk SARS-CoV-2 specimens surrogate virus neutralization test sVNT sVNT assay symptom onset time-consuming virus neutralization test [DOI] 10.1016/j.jcv.2021.104984 PMC 바로가기 [Article Type] Article
Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma고역가 회복기 혈장으로 치료한 SARS-CoV-2 폐렴 환자의 말초혈액 내 사이토카인 및 케모카인 상승Research Article Published on 2021-10-292022-09-12 Journal: PLoS Pathogens [Category] MERS, SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome addition administration Blood caused chemokine chemokines Clinical course clinical trial Cohort Concentration conducted contribute convalescent convalescent plasma Convalescent plasma therapy correlated Course COVID-19 COVID-19 pneumonia CRP cytokine Cytokine storm syndrome Cytokines Day Deterioration Disease progression Donor donors Efficacy elevated Elevation elevations evaluate fatality foundation healthy controls Hospitalization Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients IIa immune immune activation immune response IMPROVE increase in Inflammatory Inflammatory cytokines infusion institution Lung pathology mechanical ventilation MIP-1α MIP-1β Neutralizing antibodies neutralizing antibody Neutralizing titer observation outcomes pandemic Patient patients patients hospitalized patients with SARS-CoV-2 Peripheral blood phase plasma plasma sample plasma samples Pneumonia Potential biomarker potential biomarkers receive recipient recipients respiratory distress Respiratory distress syndrome resulting SARS-CoV-2 coronavirus SARS-COV-2 infection SARS-CoV-2 virus significant difference syndrome the cytokine storm the disease the patient the SARS-CoV-2 virus the timing track transfer treat treated Treatment unique virus while with COVID-19 [DOI] 10.1371/journal.ppat.1010025 PMC 바로가기 [Article Type] Research Article
Plasma Gradient of Soluble Urokinase-Type Plasminogen Activator Receptor Is Linked to Pathogenic Plasma Proteome and Immune Transcriptome and Stratifies Outcomes in Severe COVID-19가용성 Urokinase-Type Plasminogen Activator Receptor의 혈장 구배는 병원성 Plasma Proteome 및 면역 전사체와 연결되어 심각한 COVID-19의 결과를 계층화합니다Immunology Published on 2021-10-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, [키워드] 95% confidence interval Activation acute respiratory distress acute respiratory distress syndrome Analysis analyzed ARDS benefit Biomarker caused characteristic circulating Clinical outcome clinical outcomes coagulation disorder coagulation disorders Cohort complement Complement activation coronavirus COVID-19 COVID-19 disease COVID-19 patients Critical care Cutoff cutoff value cytokine Cytokines Cytometry differential expression disease effective expressed faster Flow flow cytometry Gradient hazard ratio hyper-inflammation hypercoagulable Hypercoagulable state hyperinflammation immune mass spectrometry morbidity and mortality Mortality myeloid cell myeloid cells Next-generation sequencing Odds ratio operator pathogenic patient cohort performed Peripheral blood peripheral blood cell peripheral blood cells plasma plasma sample plasma samples plasma suPAR Plaur predict Prognosis proteome proteomics receiver receptor respiratory distress risk stratification SARS-CoV-2 coronavirus Sequencing sequencing data severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients Single-cell RNA sequencing soluble uPAR statistical analyses suPAR survival syndrome systemic hyper-inflammation systemic hyperinflammation Transcriptome urokinase Urokinase-Type Plasminogen Activator was done were measured [DOI] 10.3389/fimmu.2021.738093 PMC 바로가기 [Article Type] Immunology
Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress세라마이드 수준과 CovID-19 호흡기 고통 사이의 인과 관계를 유추Article Published on 2021-10-212022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 신약개발, 치료법, [키워드] Analysis Biomarkers causal relationship ceramide Ceramides Concentration COVID-19 COVID-19 patient demonstration distress Drug development Effect exhibited increase in individual infected patients infected with COVID-19 Lipid lipids patients plasma plasma concentration plasma sample plasma samples respiratory respiratory distress respiratory symptom respiratory symptoms severe COVID-19 shown subclass Symptom therapy Translational research viral infection [DOI] 10.1038/s41598-021-00286-7 PMC 바로가기 [Article Type] Article
Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopeniaChAdOx1 백신 유도 혈소판 감소증에서 면역 복합체, 선천 면역 및 NETosisArticle Published on 2021-10-142022-09-12 Journal: European heart journal [Category] MERS, SARS, 진단, [키워드] accompanied Activation adenoviral vector vaccine analysed Analysis antibody ChAdOx1 ChAdOx1 nCoV-19 circulating complex complexes COVID-19 cytokine degranulation dsDNA endothelial damage first dose FIVE flow cytometry IgG immune immune activation Immune cell immune complex immune response immunohistochemistry Immunological response immunoprecipitation infiltration of neutrophils Inflammatory marker innate immune innate immune activation innate immune response Innate immunity leucocyte marker NETosis NETs neutrophil Neutrophil extracellular trap Neutrophils pathogenic pathway Patient patients performed plasma sample Platelet receiving reported retrieved systemic inflammation thrombotic Thrombus thrombus formation tissue Trigger vaccine-induced immune thrombotic thrombocytopenia Virus Disease [DOI] 10.1093/eurheartj/ehab506 PMC 바로가기 [Article Type] Article
Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They CanABO 혈액형에 따른 사이토카인 프로필이 COVID-19 환자의 더 나쁜 결과와 관련될 수 있습니까? 네, 그들은 할 수 있어요Immunology Published on 2021-10-132022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] 95% CI ABO ABO blood groups Admission Analysis association Biomarker Blood Group Can collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine level cytokine levels cytokine profile cytokine release Cytokines death disease group growth factor hepatocyte hepatocyte growth factor Hospital admission hospital ward intensive care intensive care unit intubation log maintenance mechanical ventilation Mortality mortality risk outcome Patient plasma sample plasma samples Prevalence profile Prognosis recruited risk severity statistically significant suggested [DOI] 10.3389/fimmu.2021.726283 PMC 바로가기 [Article Type] Immunology
The Mucosal and Serological Immune Responses to the Novel Coronavirus (SARS-CoV-2) VaccinesImmunology Published on 2021-10-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adverse effect Antibody Response Blood booster characterized clinical collected CoronaVac dominant Effect Effects elicit epithelial lining exhibited first dose IgA IgG IgG response Immunity Immunoglobulin immunoglobulin A Immunoglobulin G Immunological response inactivated Inactivated virus vaccine induce mRNA mRNA vaccine mucosal mucosal immunity nasal nasal epithelial lining fluid neutralization Neutralizing Neutralizing activity neutralizing effect novel objective other tissue plasma plasma antibody plasma sample quantified recipient response responses Result SARS-CoV-2 SARS-CoV-2 S1 protein SARS-CoV-2 vaccine serological serological immunity subject subjects vaccination Vaccine virus widespread [DOI] 10.3389/fimmu.2021.744887 PMC 바로가기 [Article Type] Immunology
Non-Invasive Antibody Assessment in Saliva to Determine SARS-CoV-2 Exposure in Young Children어린 아동의 SARS-CoV-2 노출을 결정하기 위한 타액의 비침습적 항체 평가Clinical Trial Published on 2021-10-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] age antibodies antibody applied assessment body fluid characterized children collected control group convalescent educational institutions ELISA ELISA testing ELISAs Epidemiology estimate exposure Germany individual Non-invasive pandemic plasma sample plasma samples population-based surveys positive Prevalence primary school proportion protective immunity protocol Saliva saliva samples SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-COV-2 infection school children self-reported symptom Self-reported symptoms significantly lower Specific specific antibodies specificity Tübingen [DOI] 10.3389/fimmu.2021.753435 PMC 바로가기 [Article Type] Clinical Trial
Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality그룹 IIA 분비 포스포리파제 A2는 COVID-19 사망률로 이어지는 병리생물학과 관련이 있습니다Clinical Trial Published on 2021-10-012022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, [키워드] Analysis biochemical analyses biochemical analysis Blood urea nitrogen catalytically active cellular and molecular Cellular and molecular mechanisms Cellular immune response central node circulating clinically Cohort COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 mortality COVID-19 patient death Deceased Decision tree died disease severity elevated fatal COVID-19 group hypoxia identify immune independent Inflammation inhibitor kidney dysfunction machine learning mechanism median value metabolite Mild Mild disease mitochondrial mitochondrial dysfunction Molecular pathology multiple organ dysfunction nitrogen organ dysfunction pathology Patient performed Phospholipase A2 plasma plasma sample plasma samples Random forest reduce regression analysis responsible secreted severe COVID-19 significantly Stratification survivor tested the median therapeutic target urea variable with mild disease [DOI] 10.1172/JCI149236 PMC 바로가기 [Article Type] Clinical Trial
Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam베트남의 어린이와 성인의 전염병 전 혈장에서 SARS-CoV-2 항체의 부재Article Published on 2021-10-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료법, [키워드] antibody children COVID-19 cross-reactivity demonstrated Evidence evidence of explain high risk no evidence of nucleocapsid plasma plasma sample plasma samples positive SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 nucleocapsid serological Spike proteins tested zoonosis zoonotic infection zoonotic infections [DOI] 10.1016/j.ijid.2021.07.072 PMC 바로가기 [Article Type] Article