polymorphism – Page 6 – Communicable Diseases Research

Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease

주로 전염증성 사이토카인, 사이토카인 수용체 및 톨 유사 수용체의 개별 유전적 다양성이 COVID-19 질병의 병태생리를 좌우합니다

Review

Published on 2022-09-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종,

[키워드] acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alter B cells chemokine chemokines Clinical outcome clinical outcomes coding gene coding genes condition coronavirus coronavirus disease Coronavirus disease-19 Coronavirus-2 COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity cytokine Cytokine storm Cytokines determine exacerbate Gene Expression genes encoding Genetic genetic variability Genetic variation Genetic variations Host IL10 IL17 IL4 IL6 IL7 immune immune response immune responses Immunity individual Infection Inflammation Innate interferons Monocytes Mutation natural killer cell Natural killer cells Neutrophils nucleotide pathophysiology Patient polymorphism proinflammatory cytokines receptors respiratory symptoms response SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe respiratory symptoms severity of COVID-19 Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility T cells the patient TLR TLR3 TLR7 TLR9 TLRs TNF Toll-like receptor Toll-like receptors understanding variants of concern Variation viral infection viral infections VOCs
[DOI] 10.1002/jmv.27849 PMC 바로가기 [Article Type] Review

In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivir

Research article

Published on 2022-09-012022-10-05
Journal: Chemico-biological interactions [Category] 변종, 치료제,

[키워드] Activation analyzed Anti-inflammatory drugs Antibiotics Antiviral appear AUC cannabidiol carboxylesterase 1 carrier CES1 clearance clinical study COVID-19 Dexamethasone enzyme evaluate evaluated fraction G143E hospitalized patient hydrolysis Hydroxychloroquine impairment in vitro in vitro study in vivo indicated individual inhibit inhibitor Interaction Ivermectin mechanism medication metabolism nine partial inhibition pharmacokinetic polymorphism produced RDV recent reduction Remdesivir required substrates suggested therapeutic agent treating COVID-19 Treatment unlikely variant with COVID-19
[DOI] 10.1016/j.cbi.2022.110097 [Article Type] Research article

IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohort

Article

Published on 2022-09-012022-11-15
Journal: Genes and Immunity [Category] SARS, 진단,

Unlikely influence of ABO blood group polymorphism on antibody response to COVID-19 mRNA vaccine against SARS-CoV-2 spike protein

Article

Published on 2022-09-012022-11-15
Journal: Vox Sanguinis [Category] SARS, 진단,

[키워드] ABO Antibody Response Blood Group COVID-19 mRNA vaccine polymorphism SARS-CoV-2 spike protein
[DOI] 10.1111/vox.13341 PMC 바로가기

Response to ‘Unlikely influence of ABO blood group polymorphism on antibody response to COVID-19 mRNA vaccine against SARS-CoV-2 spike protein’

Article

Published on 2022-09-012022-11-15
Journal: Vox Sanguinis [Category] SARS, 진단,

[키워드] ABO Antibody Response Blood Group COVID-19 mRNA vaccine polymorphism response SARS-CoV-2 spike protein
[DOI] 10.1111/vox.13340 PMC 바로가기

Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into Cells

Article

Published on 2022-08-312022-11-16
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 acute respiratory syndrome Affect Alter analyzed bind binding Cell cells cellular entry coronavirus CoV CoVs Effect Efficiency expressing Genetic polymorphism glycoprotein HEK293T cell host cell membrane host susceptibility Human human ACE2 human Angiotensin-converting enzyme humans Infection Interaction investigated negatively affected plasma membrane Plasmid polymorphism previous study pseudotyped Pseudotyped viruses RBD RBD of SARS-CoV-2 Receptor binding domain relative infectivity reported S protein SARS CoV SARS-CoV SARS-CoV-2 severe pneumonia significantly Single nucleotide variant SNPs SNV SNVs Spike protein stomatitis Substitution suggested Support susceptibility the binding affinity the S protein the SARS-CoV-2 thought transfected with variants of concern viral entry viral surface virus virus entry virus infection viruses were infected wild-type
[DOI] 10.1128/spectrum.00870-22 PMC 바로가기

Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unvaccinated, young adults of the Swiss Armed Forces: a longitudinal, cohort study (LoCoMo)

Research article

Published on 2022-08-262022-10-05
Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 진단,

[키워드] Administered Adults aerobic age asymptomatic infection base Blood BMI cardiovascular complications cholesterol cohort study Concentration control group COVID-19 COVID-19 group criteria defined Diagnosis diagnostic dyslipidaemia enrolled fatigue Fatigue scale female finding Follow-up force funding Health healthy higher risk individual Intensive IQR Laboratory Laboratory parameters LDL longitudinal cohort study male management median men metabolic disorder negative RT-PCR neurological no symptoms non-hospitalised organ systems outcomes participant Participants persistent physical polymorphism positive positive PCR test presenting Prevalence Psychological public health quantified questionnaire Registered renal reported reproductive RT-PCR test SARS-CoV-2 SARS-COV-2 infection Serologically serologically positive significant difference study groups Switzerland Symptom the median threshold were excluded with COVID-19
[DOI] 10.1016/S1473-3099(22)00449-2 [Article Type] Research article

Early Detection of SARS-CoV-2 Omicron BA.4 and BA.5 in German Wastewater

Article

Published on 2022-08-252022-11-15
Journal: Viruses [Category] SARS, 변종, 치료기술, 치료제,

Rapid Detection and Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Variant in a Returning Traveler

귀국 여행자의 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 오미크론 변이체의 신속한 감지 및 특성화

Case Reports

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, 치료제,

Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2

인간 유전자 TMPRSS2 및 CCR5의 대립형질 변이와 SARS-CoV-2에 의한 바이러스 감염에 대한 내성

Article

Published on 2022-08-152022-09-11
Journal: International Journal of Molecular Sciences [Category] SARS, 변종,

[키워드] addition age allelic variant allelic variants analyzed CCR5 CCR5 gene Clinical course close contact Comorbidities Comorbidity conditions contact with correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 infection demonstrated described determinant Disease progression disease severity Europe explain First wave Gender Genetic polymorphism genetic variability highest Human human genes human populations identify Italy life cycle male mortality rate mortality rates old age performed polymorphism predisposition progression resistance rs12329760 rs333 rs35074065. SARS-CoV-2 SARS-CoV-2 first wave infection SARS-COV-2 infection SARS-CoV-2 viral Sicily subject subjects TMPRSS2 TMPRSS2 gene viral infection virus virus infection with COVID-19
[DOI] 10.3390/ijms23169171 PMC 바로가기 [Article Type] Article