Rapid Spread of Mutant Alleles in Worldwide SARS-CoV-2 Strains Revealed by Genome-Wide Single Nucleotide Polymorphism and Variation Analysis게놈 전체에 걸친 단일 뉴클레오티드 다형성 및 변이 분석을 통해 밝혀진 전세계 SARS-CoV-2 균주에서 돌연변이 대립유전자의 급속한 확산Article Published on 2021-02-032022-09-11 Journal: Genome Biology and Evolution [Category] 변종, [키워드] adaptive allele Analysis benefit Clinical data coding region Complete COVID-19 COVID-19 case decrease disease disease control disease severity epidemiological survey epidemiological surveys Evidence Frequency genetic analysis genetics groups Health initial iSNV linkage groups mutant mutants mutants. nine nonsynonymous substitutions Novel coronavirus nucleotide pandemic patients polymorphism Population Population genetic analysis Population genetics positive correlation Rapid rapid increase Revealed SARS-CoV-2 sequence Seven severity single nucleotide Single nucleotide polymorphism SNP strain the disease Variation virus replication [DOI] 10.1093/gbe/evab015 PMC 바로가기 [Article Type] Article
On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all?MOLECULAR BIOLOGY and GENETICS Published on 2021-01-242022-10-30 Journal: National Science Review [Category] COVID-19, [키워드] Contagion COVID-19 Epidemic Epidemics Evolution founder effect Genetic genetic drift genetics implication infected with SARS-CoV-2 Local outbreak Outbreaks Population Population genetics positive progression regions robust SARS-CoV-2 the epidemic the SARS-CoV-2 variants [DOI] 10.1093/nsr/nwaa246 PMC 바로가기 [Article Type] MOLECULAR BIOLOGY and GENETICS
The clarifying role of time series data in the population genetics of HIVHIV의 인구 유전학에서 시계열 데이터의 명확한 역할Viewpoints Published on 2021-01-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied adaptive Antiretroviral therapy approach approaches complement decrease Diversity drift driven by drug drug resistance effective eLife Evidence evidence of Evolution explained faster Fewer patients fixation focus generate Genetic genetic diversity Genetic variation genetics HIV HIV drug HIV treatment HIV vaccine immune system less maintenance multiple drug resistance Mutation mutation rate mutations observation parameter Patient PLOS Population Population genetics population mutation populations Prevent Recombination selective sweep selective sweeps single mutations the epidemic therapy Traditional Treatment Treatment effectiveness [DOI] 10.1371/journal.pgen.1009050 PMC 바로가기 [Article Type] Viewpoints
Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures부정 주파수 의존 선택과 비대칭 변환이 다중 균주 박테리아 집단 구조를 안정화시킨다.Article Published on 2021-01-062024-07-30 Journal: The ISME Journal [Category] 폐렴구균 감염증, [키워드] Bacterial genetics Microbial ecology Microbial genetics phylogenetics Population genetics [DOI] 10.1038/s41396-020-00867-w PMC 바로가기 [Article Type] Article
Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde말라리아에 대한 빠른 적응은 카보베르데 인구의 혼합으로 촉진되었다.Article Published on 2021-01-042024-08-11 Journal: eLife [Category] 말라리아, [키워드] admixture Genetic ancestry Human natural selection Population genetics [DOI] 10.7554/eLife.63177 PMC 바로가기
Monitoring Plasmodium falciparum and Plasmodium vivax using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guineaarticle Published on 2020-12-312024-09-01 Journal: Molecular Ecology [Category] 말라리아, [키워드] malaria control Microsatellite markers Papua New Guinea Plasmodium falciparum Plasmodium vivax Population genetics Transmission dynamics [Article Type] article
Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G MutationSARS-CoV-2 스파이크 D614G 돌연변이의 진화 역학에 대한 ACE2 발현의 유전적 다양성의 영향Communication Published on 2020-12-242022-09-10 Journal: Genes [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African angiotensin Antiviral treatment Asian binding China circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D 614G D614G D614G mutation D614G variant domain driving dynamic Dynamics Efficiency enzyme Europe European Evolution Evolution of SARS-CoV-2 fusion genetic diversity Genetic variation genetics glycoprotein human population idea Impact increase in measure Mutation North North America open pandemic Population Population genetics populations Positive selection predominant public health RBD respiratory Result S glycoprotein SARS-CoV-2 selective pressure selective pressures severe acute respiratory syndrome Coronavirus spike Support the SARS-CoV-2 Transmissibility Transmission understanding variant Variation variations Viral viral evolution [DOI] 10.3390/genes12010016 PMC 바로가기 [Article Type] Communication
Imposed mutational meltdown as an antiviral strategyReview Published on 2020-10-272023-06-15 Journal: Evolution; International Journal of Organic Evolution [Category] MERS, SARS, [키워드] antivirals lethal mutagenesis Mutational meltdown Population genetics SARS‐CoV‐2 [DOI] 10.1111/evo.14107 PMC 바로가기 [Article Type] Review
The global population of SARS-CoV-2 is composed of six major subtypesArticle Published on 2020-10-262022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] accumulate amino acid replacement approach candidate vaccine characterized Clustering compose composed Computational biology and bioinformatics confounding effect COVID-19 drugs early stage Effectiveness Evolution Genes Genetic Genetic variation Genome informatics Genotype Implications Mutation nucleocapsid ORF8 pandemic phenotypic polymorphism Polymorphisms Population Population genetics populations Protein provide Randomly reduce responsible robust SARS-CoV-2 sequence subtype Subtypes the SARS-CoV-2 the Spike Trial virus World Health Organization [DOI] 10.1038/s41598-020-74050-8 PMC 바로가기 [Article Type] Article
Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population AnalysisSARS-CoV-2와 잠재적으로 관련된 숙주 유전 변이: 다중 집단 분석Genetics Published on 2020-10-022022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect African AHSG alleles allelic Analysis Asian association average calculate caused CCL2 CCL5 CD209 clinical collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease distribution EAS eQTLs European Europeans expression expression data expression quantitative trait loci Frequency furin genetic determinant genetic determinants Genetic polymorphism genetic polymorphisms genetic variants genetics Genome GWAS highlight host genetics ICAM3 identify IFN IL4 inter-individual list loci lowest modulate Multiple nucleotide outcome outcomes Population genetics populations predict promoter Quantitative respiratory Result risk risk allele SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility sequence sequences severe acute respiratory syndrome Coronavirus severity significantly significantly lower Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility TMPRSS2 variant viruses were used [DOI] 10.3389/fgene.2020.578523 PMC 바로가기 [Article Type] Genetics