Postinfection – Page 6 – Communicable Diseases Research

Infectious Clones Produce SARS-CoV-2 That Causes Severe Pulmonary Disease in Infected K18-Human ACE2 Mice

감염성 클론은 감염된 K18-인간 ACE2 마우스에서 심각한 폐 질환을 일으키는 SARS-CoV-2를 생성합니다

Research Article

Published on 2021-04-202022-09-10
Journal: mBio [Category] MERS, SARS, 치료기술,

Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera

표준화된 바이러스 중화 분석을 통해 SARS-CoV-2에 대한 절대 중화 역가를 정량화하면 COVID-19 혈청의 교차 코호트 비교가 가능합니다

Research Article

Published on 2021-02-162022-09-10
Journal: mBio [Category] MERS, 유전자 메커니즘, 진단,

[키워드] 293T ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody biosafety level Biosafety Level 3 BSL2 BSL3 clone cohorts Combination conditions convalescent-phase plasma coronavirus coronavirus disease Coronavirus disease 2019 CoV2pp COVID-19 develop Efficacy effort ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Express G glycoprotein generate group highlight identify independent inhibit inhibitory concentration intergroup comparison intergroup comparisons level 3 limit limitations Live virus myriad NAbs neutralization neutralization potency Neutralizing antibodies neutralizing antibody Neutralizing titer overcome pandemic Particle Patient plasma positive correlation Postinfection produced pseudotyped Renilla luciferase gene respiratory SARS-CoV-2 Screen sera severe acute respiratory syndrome Coronavirus spike glycoprotein stomatitis Support therapy titer TMPRSS2 Vaccine Variability vesicular stomatitis vesicular stomatitis virus Viral viral entry viral neutralization assay virus neutralization assay VSVΔG
[DOI] 10.1128/mBio.02492-20 PMC 바로가기 [Article Type] Research Article

Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies

SARS-CoV-2 스파이크 대 핵단백질 항체 반응의 변화는 인구 기반 혈청 유병률 연구에서 감염 추정에 영향을 미칩니다

Pathogenesis and Immunity

Published on 2020-11-032022-09-10
Journal: Journal of Virology [Category] 진단, 치료법, 치료제,

[키워드] acute infection acute phase acute respiratory syndrome acute respiratory syndrome coronavirus anti-N antibodies anti-N antibody anti-S antibody anti-S IgG Antibody binding Antibody detection Antibody Response Antibody responses Antigen assays binding change characterization Cohort cohorts conformational coronavirus Critical enrolled epitope Epitopes estimate evaluate evaluated General population generate greater Impact individual Infection Luminex assay monomer monomeric N protein N protein assay nucleocapsid nucleoprotein Patient population study Postinfection Protein ranged reduction in respiratory response responses responses against S protein S protein trimer S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sera Serological assay serology Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly more spike subjects Switzerland the antibody response the N protein the S protein trimer trimeric trimeric S protein vaccine-induced antibody response viral S was reduced
[DOI] 10.1128/JVI.01828-20 PMC 바로가기 [Article Type] Pathogenesis and Immunity

The Interaction of Natural and Vaccine-Induced Immunity with Social Distancing Predicts the Evolution of the COVID-19 Pandemic

Research Article

Published on 2020-10-232022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome coronavirus COVID-19 Critical effective Immunity limit natural neutralizing antibody occur other coronavirus Postinfection Prevent public health SARS-CoV-2 social distancing Spread the SARS-CoV-2 virus thought Vaccine Vaccines virus
[DOI] 10.1128/mBio.02617-20 PMC 바로가기 [Article Type] Research Article

Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport

Review

Published on 2020-10-192022-10-27
Journal: BMJ Open Sport — Exercise Medicine [Category] COVID-19,

[키워드] affected appear approach biological profile cardiac complication Cardiology Cardiovascular disorders clinical manifestation Community consequence cough COVID-19 COVID-19 infection COVID-19 pandemic diabete disease spread Dyspnoea evaluate exercise fatigue Fever globe headache Health hypertension hypoxaemia individual individuals managing Medical conditions MONITOR multiorgan failure myalgia myocarditis occur physical ability Physiology Postinfection reduce reported respiratory Respiratory failure risk Safe severe cases Shock sore throat sports & exercise medicine stoppage Symptom Symptoms symptoms of COVID-19 the disease
[DOI] 10.1136/bmjsem-2020-000849 PMC 바로가기 [Article Type] Review

Subacute Thyroiditis Associated with COVID-19

Case Report

Published on 2020-09-282022-10-31
Journal: Case Reports in Endocrinology [Category] COVID-19,

S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit

Research Article

Published on 2020-09-252022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] accompanied acute respiratory syndrome Analysis analyzed anti-N IgG anti-S2 antibody antibody production asked B cell B cell response circulating conserved convalescent coronavirus coronavirus disease correlated strongly COVID-19 cross-reactive disease ENhance frequencies generate healthy donor Human human coronavirus OC43 IgG IgG antibodies IgG level IgG titer immune memory immune protection Immunity individuals Infection MBC memory B cell memory B cells mononuclear cell MOST non-SARS-CoV-2 protein nucleocapsid pandemic PBMCs Peripheral blood Population Postinfection Production Protein provide RBD reactive Receptor binding domain reflect Reinfection S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera specificity Spike protein Spread subject subjects susceptibility susceptible the RBD the S protein the SARS-CoV-2 virus Virus-specific IgG
[DOI] 10.1128/mBio.01991-20 PMC 바로가기 [Article Type] Research Article

Prophylactic (hydroxy)chloroquine in COVID-19: Potential relevance for cardiac arrhythmia risk

Research article

Published on 2020-09-012022-10-05
Journal: Heart Rhythm [Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome addition addressed affected approach arrhythmia Arrhythmias benefit Cardiac arrhythmia cardiovascular disease Chloroquine clinical trial coronavirus COVID-19 demonstrated disease drugs ECG Effects electrocardiographic Evidence female patient Genetic hospital Hydroxychloroquine induce Infection investigated life-threatening Patient patients with COVID-19 performed Postinfection Potential preventive measure Prophylactic prophylactically Prophylaxis provide QT QT interval QT prolongation recommendation recommendations reduce risk SARS-CoV-2 suggested therapy torsades de pointes Treatment treatment for COVID-19
[DOI] 10.1016/j.hrthm.2020.07.001 [Article Type] Research article

A Model for SARS-CoV-2 Infection with Treatment

Research Article

Published on 2020-09-012022-10-31
Journal: Computational and Mathematical Methods in Medicine [Category] COVID-19, MERS, SARS,

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

530

Published on 2020-07-142022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome addition animal model antiviral drugs Characteristics China consequence consolidation convalescent serum coronavirus coronavirus disease countermeasure COVID-19 patient disease feature Ground glass opacity hamster hamsters Health human lung immunotherapies Infection inhibited intranasal isolate lesion lung lung lesion Lungs mounted naïve Neutralizing antibody response Novel coronavirus pathogenesis of SARS-CoV-2 Pneumonia Postinfection Region replicate replicated Replication replicative reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 pathogenesis serum severe lung injury Significance Spread subsequent suppressed Syrian hamsters transfer Vaccine Vaccines virus virus replication Wuhan, China
[DOI] 10.1073/pnas.2009799117 PMC 바로가기 [Article Type] 530