COVID-19 Pandemic: Knowledge, Attitude, and Perception of Medical Students Toward the Novel Coronavirus DiseaseOriginal Research Published on 2021-06-072022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, [키워드] Attitude concerning conducted coronavirus coronavirus disease COVID-19 COVID-19 virus cross-sectional expected Features female Gender Infection information knowledge majority management medical students no significant difference novel participant Perception positive attitude Preclinical predicted prevention preventive measure preventive measures questionnaire reported significantly more socio-demographic student the disease the epidemic were assessed [DOI] 10.1017/dmp.2021.169 PMC 바로가기 [Article Type] Original Research
Zebrafish as a Translational Model: An Experimental Alternative to Study the Mechanisms Involved in Anosmia and Possible Neurodegenerative Aspects of COVID-19?번역 모델로서의 Zebrafish: 후각 상실과 COVID-19의 가능한 신경퇴행성 측면과 관련된 메커니즘을 연구하기 위한 실험적 대안?Review Published on 2021-05-052022-09-10 Journal: eNeuro [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Anosmia aspect Asymptomatic Brain classical Clinical symptoms Cohort cohort of patients conditions coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Danio Effect embryonic embryonic development Encephalitis feature functions Genetic genetic manipulation high availability induce investigated Logistic long-lasting mammalian mechanism neurodegeneration neurologic neurologic disorders neuroscience olfactory Olfactory system organism pandemic pathway Preclinical replications respiratory respiratory manifestations SARS-CoV-2 severe acute respiratory syndrome Coronavirus similarity suggested Symptom Treatment Variability Visual with COVID-19 zebrafish [DOI] 10.1523/ENEURO.0027-21.2021 PMC 바로가기 [Article Type] Review
Rationale and design of the pragmatic randomized trial of icosapent ethyl for high cardiovascular risk adults (MITIGATE)심혈관 위험이 높은 성인을 위한 icosapent ethyl의 실용적인 무작위 시험의 이론적 근거 및 설계(MITIGATE)Multicenter Study Published on 2021-05-012022-09-11 Journal: American heart journal [Category] 임상, [키워드] age anti-inflammatory property Antiviral approved atherosclerotic Atherosclerotic cardiovascular disease by mouth Cardiopulmonary cardiovascular disease cardiovascular risk Care clinical effectiveness clinical observation clinical observations Clinical practice clinical status clinical trial clinics co-primary endpoint co-primary endpoints cohort of patient consequence control group coronavirus disease Coronavirus disease 2019 COVID-19 downstream elevated evaluate Evidence fatty Fatty acid Follow-up Health Health care Health status hospital Icosapent icosapent ethyl Intervention laboratory-confirmed mitigate morbidity and mortality mouth omega-3 omega-3 fatty acid Open-label participant pleiotropic effect Pleiotropic effects Pragmatic Preclinical preclinical data prescription medication Prevent purified Randomized randomized trial rationale reduce reduction in respiratory infection seasonal flu statin stratified therapy triglycerides upper respiratory infection usual care viral upper respiratory infection. [DOI] 10.1016/j.ahj.2021.01.018 PMC 바로가기 [Article Type] Multicenter Study
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trialCOVID-19에 대한 이트라코나졸: 전임상 연구 및 개념 증명 무작위 임상 시험Randomized Controlled Trial Published on 2021-03-192022-08-13 Journal: EBioMedicine [Category] MERS, SARS, 비임상, 신약개발, 임상, 진단, 치료제, [키워드] 7-point ordinal scale 95% CI absence acute infection acute SARS-CoV-2 infection adequate plasma antifungal drug itraconazole antivirals assigned breath Caco-2 clinical status Clinical studies clinical study clinical trial COVID-19 cumulative score did not reduce drug concentrations Drug repurposing effective evaluated finding foundation funding geometric Geometric means Health Organization Horizon hospitalized COVID-19 patient hospitalized COVID-19 patients human Caco-2 cells ileum in vitro activity initial interim analysis itraconazole Leuven lung Lungs Melinda Gate Melinda Gates not effective Open-label Ordinal Scale outcome Preclinical preclinical studies preclinical study premature termination Prevent prevention of COVID-19 Primary outcome proof-of-concept clinical study randomized clinical trial Randomly required SARS-CoV-2 SARS-COV-2 infection showed no signal single-center study Standard of care Stool stools Transmission Transmission model Treatment Vero Viral Viral load viral load in lungs Viral transmission World Health Organization [DOI] 10.1016/j.ebiom.2021.103288 PMC 바로가기 [Article Type] Randomized Controlled Trial
Mechanisms Modified by (−)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical StudiesReview Published on 2021-03-162022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] Alter Angiotensin II Anti-inflammatory antioxidant antioxidants Antiviral antiviral effects benefit blood pressure cardiovascular system cellular and molecular COVID-19 dihydroquercetin Effect endothelial function Health hypertension hypertensive IMPROVE knowledge mechanism molecular mechanism nitric oxide notable Nrf2 pandemic physiological Preclinical preclinical studies red blood cell deformability SARS-CoV-2 SARS-COV-2 infection shown subject Treatment was determined [DOI] 10.3390/antiox10030467 PMC 바로가기 [Article Type] Review
Preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidatesArticle Published on 2021-03-112022-10-04 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, [키워드] absence added Analysis antibody production Antibody-dependent enhancement applied B cell response B cell responses BALB/c mice candidate candidate vaccine caused COVID-19 outbreak Diseases effective Efficacy Efficacy and safety GM-CSF Health humanized immunology in vitro in vivo inactivated Inactivated vaccine infective mice Microbiology morbidity and mortality neutralization capacity Pathogenesis peptide pool performed Preclinical reducing reported SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 virus T cell T cell response the vaccine Toxicity Vaccine vaccine candidate virus [DOI] 10.1038/s41598-021-83930-6 PMC 바로가기 [Article Type] Article
Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine: Preclinical Studies비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 전임상 연구Article Published on 2021-03-032022-09-10 Journal: Vaccines [Category] 비임상, [키워드] Antibody titers approved AstraZeneca booster booster dose breath candidate vaccine challenge clinical development clinical trial control group country effective Efficacy Emergency use experimental models guinea pigs hamster hamsters immunogenicity immunological profile inactivated increase in Infection Laboratory mice Moderna morbidity mRNA Neutralizing antibody titer neutralizing antibody titers pandemic performed Phase I PIGS post vaccination pre-clinical study Preclinical preclinical studies RATs Safety safety evaluation SARS-CoV-2 SARS-CoV-2 vaccine shedding Sinopharm subjects tested the vaccine tolerable Vaccine vaccine safety virus [DOI] 10.3390/vaccines9030214 PMC 바로가기 [Article Type] Article
Feasibility study of assessing the Preclinical Alzheimer Cognitive Composite (PACC) score via videoconferencing화상회의를 통한 전임상 알츠하이머 인지 종합(PACC) 점수 평가 타당성 조사Original Communication Published on 2021-01-262022-09-10 Journal: Journal of Neurology [Category] MERS, SARS, 치료기술, [키워드] 95% CI Administered Ageing assessment assessments calculated can not Clinical practice cognitive Cognitive decline Cognitive impairment Cognitive testing Composite correlation costly COVID-19 pandemic detect Evidence feasibility Feasibility study finding game IQR median Mild cognitive impairment Multiple linear regression objective participant Pearson correlation coefficient performed positive correlation Preclinical provide Research supplementary material Telemedicine Validity variable videoconferencing [DOI] 10.1007/s00415-021-10403-1 PMC 바로가기 [Article Type] Original Communication
An overview of preclinical animal models for SARS-CoV-2 pathogenicityReview Article Published on 2021-01-012023-06-15 Journal: The Indian journal of medical research [Category] MERS, [키워드] animal models COVID-19 Pathogenesis Preclinical SARS-CoV-2 therapy Vaccine [DOI] 10.4103/ijmr.IJMR_3215_20 PMC 바로가기 [Article Type] Review Article
Immunocompetent Mouse Models in the Search for Effective Immunotherapy in GlioblastomaReview Published on 2020-12-232023-08-30 Journal: Cancers [Category] E형 간염, [키워드] animal model Glioblastoma immune response Immunotherapy Model murine Preclinical [DOI] 10.3390/cancers13010019 PMC 바로가기 [Article Type] Review