Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaquesResearch article Published on 2022-05-252022-10-05 Journal: iScience [Category] 비임상, [키워드] blunting cells clinical trials decrease explain FIVE Hospitalization hospitalized patient increases in Infection innate immune response intensity lung lung damage lung viral load Lungs mathematical modeling Molecular modeling nasal nasal passage nasal passages occur Pneumonia prevented raise reducing reduction in Remdesivir rhesus macaque rhesus macaques SARS- CoV-2 SARS-CoV-2 shedding relative therapy Viral load viral loads Virology [DOI] 10.1016/j.isci.2022.104448 [Article Type] Research article
Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in miceSARS-CoV-2 복제를 감소시키고 마우스에서 염증 유발 폐 손상을 완화하기 위한 항히스타민제와 렘데시비르의 조합 이점Article Published on 2022-05-182022-09-11 Journal: Zoological research [Category] COVID19(2023년), SARS, 치료제, [키워드] alveolar antagonist Anti-inflammatory Anti-inflammatory therapy Antihistamine Antihistamines Antiviral antiviral drug antiviral therapy benefit caused Chinese clinical benefits Combination Combinational therapy COVID-19 COVID-19 treatment degranulation demonstrated Endothelial cell English epithelial feasible Histamine histamine receptor hyperinflammation Immune-mediated in vivo Inflammation inflammation-induced lung injury inflammatory disease initiate Injury lAbel loratadine Lung injury lung lesion lung lesions mast cell Mast cells MCs mediator mice off-label off-label use predicted Prevent prevented receptor reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike protein Spike protein suggested suppress Treatment viral replication [DOI] 10.24272/j.issn.2095-8137.2021.469 PMC 바로가기 [Article Type] Article
Icon arrays reduce concern over COVID-19 vaccine side effects: a randomized control studyRandomized Controlled Trial Published on 2022-05-072022-10-04 Journal: Cognitive research: principles and implications [Category] COVID19(2023년), SARS, 임상, [키워드] Administered administration American aversion Blood CDC changes in COVID-19 vaccine COVID-19 vaccines Icon increases in MOST Prevent prevented randomized control study reduce risk Side effect significantly the vaccine Vaccine Vaccine hesitancy [DOI] 10.1186/s41235-022-00387-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors조합 AAV/RNAi 발현 벡터를 사용한 SARS-CoV-2의 생체외 및 생체내 억제Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] AAV acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adeno-associated virus Antiviral Antiviral agents antiviral RNAi Cell clinically cocktail complement coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease symptom effective escape mutant escape mutants experiment expression vector flexible Genetic global effort Gut hACE2 in vivo infected cell infected cells intestinal cells intranasal mice mutational escape. N gene N genes organoids pandemic prevented RdRP RNA RNAi SARS virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus suppressed the SARS-CoV-2 therapeutic translation triggers Vaccine vector vectors viral adaptation Viral load viral loads virus wild-type [DOI] 10.1016/j.ymthe.2022.01.024 PMC 바로가기 [Article Type] Article
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomicsCOVID-19 햄스터 모델에서 덱사메타손 및 항체 치료의 주요 이점, 단일 세포 전사체로 밝혀짐Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Anti-inflammatory anti-inflammatory effect anti-inflammatory properties anti-inflammatory property anti-SARS-CoV-2 antibody Anti-viral anti-viral effect anti-viral effects antibodies antibody antibody treatment benefit Cell combination therapy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Dexamethasone disease drugs Effect effective Efficacy exhibited hamster host responses immune responses Immunity Infection Inflammatory inflammatory cell lung Lungs mechanisms monoclonal antibody monoclonal antibody therapy Neutrophils potential mechanism prevented pulmonary pulmonary immune response recruitment respiratory SARS-CoV-2 scRNA-seq severe disease single-cell Standard-of-care subpopulation synergistic synergistic effects therapeutic option therapeutic options Therapies therapy transcriptomic transcriptomics Treatment Vaccine vaccine efficacy Vaccine hesitancy variants Viral viral burden was reduced [DOI] 10.1016/j.ymthe.2022.03.014 PMC 바로가기 [Article Type] Article
Investigation of a COVID-19 outbreak on the Charles de Gaulle aircraft carrier, March to April 2020: a retrospective cohort study2020년 3월부터 4월까지의 Charles de Gaulle 항공모함에서 발생한 COVID-19 발병 조사: 후향적 코호트 연구Article Published on 2022-05-012022-09-11 Journal: Eurosurveillance [Category] COVID19(2023년), SARS, 치료기술, [키워드] acceleration active smoking adjusted age aircraft Aircraft Carrier applied Armed Forces Asymptomatic attack rate Charles de Gaulle circulation clinical picture Cohort collected COVID-19 COVID-19 outbreak effective Effectiveness epidemiological data examined France French herd immunity Infection instantaneous introduced investigation Isolation lack measure median age non-specific obesity occurred outbreak oxygen Oxygen therapy performed physical distancing Prevent prevented preventive measures proportion Protective reached Reproduction rate retrospective cohort study risk factor Risk factors SARS-CoV-2 SARS-CoV-2, COVID-19 searched Sequencing severe COVID-19 severity Ship, Herd immunity. smoking Spread strain suggested Surveillance symptomatic threshold Viral genome sequencing virus [DOI] 10.2807/1560-7917.ES.2022.27.21.2100612 PMC 바로가기 [Article Type] Article
Simultaneous Measurement of IgM and IgG Antibodies to SARS-CoV-2 Spike, RBD, and Nucleocapsid Multiplexed in a Single Assay on the xMAP INTELLIFLEX DR-SE Flow AnalyzerxMAP INTELLIFLEX DR-SE 유량 분석기에서 단일 분석으로 다중화된 SARS-CoV-2 스파이크, RBD 및 뉴클레오캡시드에 대한 IgM 및 IgG 항체의 동시 측정Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료법, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analyzer angiotensin angiotensin-converting enzyme 2 antibody Antibody binding Antibody Response Antigen binding convalescent coronavirus COVID-19 declined demonstrated described Evidence Flow fluorescent fluorescent microsphere immunoassay FMIA future work greater IgG antibody IgM IgM and IgG immunoassay include Infection investigated measurement microsphere multiplex neutralization nucleocapsid Patient peaked prevented profile Protein provided RBD RBD-specific IgG Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike semi-quantitative Serological assay serological response serology severe acute respiratory syndrome Coronavirus Simultaneous Specific specific antibodies specific IgM specimen spike spike glycoprotein Spike protein symptom onset symptomatic case the SARS-CoV-2 trajectory variant variants of SARS-CoV-2 Viral Viral antigen Volume [DOI] 10.1128/spectrum.02507-21 PMC 바로가기 [Article Type] Article
Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron치명적인 SARS-CoV-2 감염 표적 수용체 결합 에피토프로부터 보호하는 나노바디는 오미크론 이외의 바이러스 변이체에 보존되어 있습니다Article Published on 2022-04-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] affinity antibody binding binding epitope binding mode blocked cell cultures cell entry cell entry receptor competition coronavirus COVID-19 COVID-19 pandemic cryo Cryo-electron microscopy electron microscopy Epitopes fusion glycoprotein groups hACE2 heavy chain human ACE2 humanized immune Immune escape immunized lethal mice Microscopy mono MOST nanobodies nanobody neutralization neutralized Neutralizing Neutralizing antibodies neutralizing antibody nine omicron Other Prevent prevented progression Protecting pseudotyped RBD RBD binding RBM receptor receptor binding motif Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants selected target the receptor-binding domain the S protein therapeutic potential Therapeutics Vaccine variant variants of concern virus [DOI] 10.3389/fimmu.2022.863831 PMC 바로가기 [Article Type] Article
A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2 Research Published on 2022-04-252022-10-05 Journal: NPJ Vaccines [Category] 유전자 메커니즘, [키워드] antibody Cell Critical detectable domain dose effective expressing full-length S functions generate hamster human parainfluenza virus induce Infection Inflammation intranasal less lung memory T mucosal mucosal immune Mutation neutralizing antibody pathway prevented PROTECT Protein respiratory response S protein S1 subunit SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 vaccines SARS-CoV-2 variants tested the antibody response the disease the receptor-binding domain vaccination vaccination against COVID-19 Vaccine Vaccines viral replication [DOI] 10.1038/s41541-022-00471-3 [Article Type] Research
Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 InfectionSARS-CoV-2 감염 시 인테그린과 캐드헤린 간의 분자 상호작용으로 혈관 장벽 무결성 상실Article Published on 2022-04-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] abnormal coagulation barrier cadherin candidate cilengitide complex Complication contribute COVID-19 Cytokine storms dysregulation Effects elicit endothelial endothelial cells Endothelial dysfunction Endotheliitis event events expressed Extracellular homeostasis Hypoxemia inhibitor integrin integrin αVβ3 Integrins integrity internalization intracellular signaling life-threatening Loss mechanism motif multiple organ failure Pathways peptide phenotype phlogistic prevented Protein receptor redistribution RGD motif SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Spike protein Support the spike protein thrombotic Thrombotic complications Trigger Vascular vascular dysfunction vascular leakage [DOI] 10.3390/v14050891 PMC 바로가기 [Article Type] Article