Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic풍진 바이러스의 과돌연변이된 게놈과 COVID-19 전염병 동안 축적된 SARS-CoV-2 게놈의 돌연변이 스펙트럼 간의 유사성Research Article Published on 2020-10-022022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] accumulated accumulation Analysis APOBEC cytidine deaminase change characteristic COVID-19 pandemic cytidine Cytidine deaminase dataset Each enrichment event genomes genomic RNA human population hypermutated genome hypermutated genomes hypermutation individual isolate lead motif Mutation mutation mechanism mutation mechanisms mutational spectrum new SARS-CoV-2 pathological condition positive predicted preference Propagation reported RNA secondary structure RNA virus rubella rubella vaccine rubella vaccine virus rubella virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 viruses SARS-CoV2 secondary structure sequenced similarity single base substitution single base substitutions single subject strand genomic RNA subclass substitutions suggested the SARS-CoV-2 virus virus isolate viruses [DOI] 10.1371/journal.pone.0237689 PMC 바로가기 [Article Type] Research Article
Characterizing the Impact of Social Inequality on COVID-19 Propagation in Developing CountriesMathematics Published on 2020-09-182022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] absence Affect Brazil country COVID-19 COVID-19~propagation deep Developing developing countries Effect Epidemic fatality Health health condition heterogeneity hygiene Impact inequality measure Measures mechanism Mortality Non-pharmaceutical interventions number of infected outbreak pandemic pharmaceutical Pharmaceutical interventions Population predict Propagation SEIR social distancing social inequality Spread virus with COVID-19 [DOI] 10.1109/ACCESS.2020.3024910 PMC 바로가기 [Article Type] Mathematics
Space-Time Patterns, Change, and Propagation of COVID-19 Risk Relative to the Intervention Scenarios in BangladeshArticle Published on 2020-08-142022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] Analysis Care change Cluster conducted coronavirus country COVID-19 COVID-19 infection COVID-19 transmission disease tracking and monitoring early phase emerging space-time pattern Europe exhibiting Health high risk Infectious disease Infectious disease surveillance Intervention introduced Isolation less measure Middle East novel Novel coronavirus NPI pandemic Potential Pragmatic progression Propagation public health threat Region relative remained SARS-CoV-2 SatScan scenario Spread the disease Transmission while [DOI] 10.3390/ijerph17165911 PMC 바로가기 [Article Type] Article
Modelling Strong Control Measures for Epidemic Propagation With Networks—A COVID-19 Case StudyCircuits and Systems Published on 2020-06-102022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] Agent based model build Characteristics Community Complex network Contact contact graph contributing to Control COVID-19 disease effective Epidemic estimate estimates exhibit individual Infectious diseases knowledge measure Measures Novel coronavirus pandemic parameter Propagation propagation on networks random required SEIR selected Spread Strong Topology Transmission transmission parameter utility [DOI] 10.1109/ACCESS.2020.3001298 PMC 바로가기 [Article Type] Circuits and Systems
Propagation, Inactivation, and Safety Testing of SARS-CoV-2Article Published on 2020-06-062022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Biosafety Level 3 causes Cellulose Chinese coronavirus COVID-19 deaths described DNA effective facilitated focus forming assay inactivation infected cell Infection Infectious virus multiple cell line neutral buffered formalin new virus Novel coronavirus pandemic performed Plaque assay Propagation Protein quantification Research responsible resulting RNA Safe Safety SARS-CoV-2 Testing the disease Trizol Virology virus virus infectivity widespread worldwide pandemic Wuhan [DOI] 10.3390/v12060622 PMC 바로가기 [Article Type] Article
Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies새로운 효모 단백병증 모델 및 유전자 변형 파리에서 PBP1/ATXN2 기능의 손실에 의해 칼슘 반응성 트랜스활성제(CREST) 독성이 구출됩니다Research Article Published on 2019-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Affect aggregate aggregation ALS Amyotrophic lateral sclerosis ATXN2 calcium caused chaperone CREST cytoplasmic degenerative Deletion disease Disease model Diseases downregulation Drosophila effective enhancer expressed facilitate foci form ganglion cell ganglion cells Genes inhibit Lateral Sclerosis Like Localization mammalian cells mechanism modify Mutation neurodegenerative neurons nuclear ortholog overexpressing overexpression phenotype Propagation Protein Proteins reduce reduced regulated required rescued risk factor shown Spectrum SS18L1 targets therapeutic target therapy Thioflavin toxic Toxicity transgenic yeast yeast form yeast forms [DOI] 10.1371/journal.pgen.1008308 PMC 바로가기 [Article Type] Research Article
Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous BatArticle Published on 2019-02-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Activation Antiviral antiviral response antiviral responses antiviral signaling bat bats cause Cell cells coronavirus CoV Critical demonstrated determine develop disease Eptesicus examined Factor fatality hallmark Host Human human cell human cells Hypothesis IFNβ interferon interferon beta IRF3 less MERS MERS-CoV nuclear translocation post-translational modifications Propagation Protein regulated replicate respiratory RNA siRNA suppressed suppression syndrome tested the interferon viral double-stranded RNA virus [DOI] 10.3390/v11020152 PMC 바로가기 [Article Type] Article
CDI/CDS system-encoding genes of Burkholderia thailandensis are located in a mobile genetic element that defines a new class of transposonBurkholderia thailandensis의 CDI/CDS 시스템 인코딩 유전자는 새로운 종류의 트랜스포존을 정의하는 이동성 유전 요소에 있습니다.Research Article Published on 2019-01-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition allele Bacteria Bacterial Burkholderia CDS Cell cells Characteristics chromosome Community community development composed cooperation Critical DNA dsDNA element Escherichia coli Evidence facilitate fitness functional Genes genes encoding Genetic genetic material growth helping immune Immunity induce inhibit insertion insertion sequence Interaction Intercellular communication involved killing lack left mechanism microbial Microbial communities Mobility occur Organisms phenomenon Phenotypes Propagation Protein provide reaction required self sequence sequences Signaling Support synthesis target cell transposon turn [DOI] 10.1371/journal.pgen.1007883 PMC 바로가기 [Article Type] Research Article
Hepatitis E Virus: Isolation, Propagation, and QuantificationArticle Published on 2018-02-222023-06-11 Journal: Curr Protoc Microbiol [Category] E형 간염, [키워드] HEV Isolation Propagation Virus quantification [DOI] 10.1002/cpmc.50
Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo고유한 프리온 도메인 서열은 생체 내 샤페론 결합 또는 처리를 촉진하여 효율적인 아밀로이드 증식을 보장합니다Research Article Published on 2016-11-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting aggregate Alter Amino acid amyloid assembly binding change chaperone chaperones complementary composed conformation conformational conformational flexibility contribute creating efficient element elements Ensure functional in vitro in vivo inheritance Interaction maintain mechanism molecular observation occur open persistence physical physical properties predict prion processing promote Promoting Propagation Protein Protein misfolding Proteins proximal PSI question Regulation required resulting sequence Spectrum stability Transmission yeast [DOI] 10.1371/journal.pgen.1006417 PMC 바로가기 [Article Type] Research Article