Programmed cell death: the pathways to severe COVID-19?Review Published on 2022-03-182023-06-16 Journal: Biochemical Journal [Category] MERS, SARS, [키워드] Apoptosis COVID-19 Inflammation necroptosis pyroptosis Therapeutics [DOI] 10.1042/BCJ20210602 PMC 바로가기 [Article Type] Review
IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal PneumosepsisIL-6는 폐 포식세포의 사멸과 폐 염증 손상을 예방하며, 폐렴구균 폐렴패혈증 동안 GSDME 및 GSDMD 매개 발열세포사(apoptosis)를 억제합니다.Article Published on 2022-03-172024-07-28 Journal: Microbiology Spectrum [Category] 폐렴구균 감염증, [키워드] IL-6 Inflammation Macrophage pneumococcal pneumosepsis pyroptosis [DOI] 10.1128/spectrum.02049-21 PMC 바로가기
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine Research Published on 2022-03-142022-10-05 Journal: Nature Immunology [Category] 치료제, [키워드] adaptive analyzed antibody BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine CD8+ T cell cell death pathways circulating dependent on draining lymph node Efficacy IFN-γ immune responses Immunity immunization immunological mechanism inflammasome activation innate response interferon knockout mice MDA5 mice molecular mechanism natural killer cell necroptosis Pfizer-BioNTech pyroptosis response serum Signaling stimulate stimulated T cell response T cell responses Toll-like receptor type I underlie [DOI] 10.1038/s41590-022-01163-9 [Article Type] Research
Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a CoinSARS-CoV-2에 의한 타고난 면역 반응의 탈출 및 과잉 활성화: 동전의 두 얼굴Review Published on 2022-03-042022-09-11 Journal: Viruses [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] addition cellular receptor coin coronavirus CoV COVID-19 pathogenesis CoVs Cytokines Defense disease dysregulated escape evade face Host human population IFN IFN signaling pathways IL-1 IL-1 family cytokine IL-1 family cytokines IL-18 IL-1β immune responses Inflammasome inflammasome activation inflammasomes Innate innate immune innate immune response innate immune responses innate immune system Innate immunity interferon invading pathogens MERS MERS-CoV Multiple Pathogenesis Pathogens potential mechanism potential mechanisms Prognosis pyroptosis Recognition response SARS-CoV-1 SARS-CoV-2 with COVID-19 [DOI] 10.3390/v14030530 PMC 바로가기 [Article Type] Review
Molecular hydrogen is a potential protective agent in the management of acute lung injuryReview Published on 2022-03-032022-10-30 Journal: Molecular Medicine [Category] COVID-19, [키워드] acute lung injury acute respiratory distress alleviate Anti-inflammation antioxidation Apoptosis autophagy cause caused cell death Clinical treatment COVID-19 critically ill patients demonstrated Diseases Effect Efficacy Inflammation life-threatening Lung injury management mechanism modulation molecular Molecular hydrogen novel coronavirus disease pandemic Pathogenesis Protective pyroptosis ROS Severe respiratory distress syndrome therapeutic effect therapy treatment method [DOI] 10.1186/s10020-022-00455-y PMC 바로가기 [Article Type] Review
Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed TherapiesCOVID-19 발병, 후유증 및 직접 요법의 카스파제에 대한 새로운 통찰력Review Published on 2022-02-212022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] accumulating activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis apoptotic approved benefit broad spectrum caspase Caspases caused Cell cell death characterized clinical manifestation clinical manifestations Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current therapy cytokine cytokine release death disease disease severity downstream dysregulated effective effort Evidence expressed expression family members health emergency high risk highest highlight Hypercoagulation IL-18 IL-1β immune immune responses immunological immunological mechanism in some in vitro individual inflammasomes Inflammation inflammatory mediator Inflammatory mediators inhibitor insight Manifestations mediators multi-organ failure multiprotein complex non-immune observational studies observational study occur outcomes pathology Pathways Prevent progression pyroptosis receptor signaling respiratory risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic therapeutic intervention upstream Vaccines variant [DOI] 10.3389/fimmu.2022.842740 PMC 바로가기 [Article Type] Review
Gasdermin D Inhibits Coronavirus Infection by Promoting the Noncanonical Secretion of Beta InterferonResearch Article Published on 2022-02-012023-06-12 Journal: mBio [Category] MERS, [키워드] coronavirus GSDMD IFN-β PDCoV pyroptosis TGEV [DOI] 10.1128/mbio.03600-21 PMC 바로가기 [Article Type] Research Article
The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in miceArticle Published on 2022-02-012023-06-14 Journal: European Journal of Immunology [Category] Fulltext, 신종인플루엔자, [키워드] GTPases Inflammasome influenza A virus IRGB10 NLRP3 pyroptosis [DOI] 10.1002/eji.202149305 PMC 바로가기
Salmonella Infection Causes Hyperglycemia for Decreased GLP-1 Content by Enteroendocrine L Cells Pyroptosis in Pigs살모넬라 감염은 돼지의 장내내분비 L 세포의 피로ptosis로 인해 GLP-1 함량 감소로 고혈당증을 유발한다.Article Published on 2022-01-242024-07-29 Journal: International Journal of Molecular Sciences [Category] 살모넬라증, [키워드] enteroendocrine L cell GLP-1 hyperglycemia pig pyroptosis Salmonella [DOI] 10.3390/ijms23031272 PMC 바로가기 [Article Type] Article
Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 FragmentResearch Article Published on 2022-01-112022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition Amino acid cleave cleaved coronavirus CoV CoV infection CoVs Critical epidemic diarrhea Evidence facilitate fragment gasdermin D GSDMD hepatic disease humans Infection inhibit initial MERS-CoV molecular mechanism nsp5 pathway PEDV protease pyroptosis Regulation Replication RNA virus SARS-CoV-2 viral replication virus [DOI] 10.1128/mbio.02739-21 PMC 바로가기 [Article Type] Research Article